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Wilma Ormiston
Researcher at Trinity College, Dublin
Publications - 8
Citations - 3771
Wilma Ormiston is an academic researcher from Trinity College, Dublin. The author has contributed to research in topics: Breast cancer & Genetic linkage. The author has an hindex of 8, co-authored 8 publications receiving 3649 citations.
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Journal ArticleDOI
Localization of a breast cancer susceptibility gene, BRCA2, to chromosome 13q12-13
Richard Wooster,Susan L. Neuhausen,Jonathan Mangion,Yvette Quirk,D Ford,N. Collins,K. Nguyen,Sheila Seal,T.D. Tran,D. Averill,P Fields,Gill Marshall,Steven A. Narod,Gilbert M. Lenoir,Henry T. Lynch,Jean Feunteun,Peter Devilee,Cees J. Cornelisse,Fred H. Menko,Peter A. Daly,Wilma Ormiston,Ross McManus,Carole Pye,Cathryn M. Lewis,Lisa A. Cannon-Albright,Julian Peto,Bruce A.J. Ponder,Mark H. Skolnick,Douglas F. Easton,David E. Goldgar,Michael R. Stratton +30 more
TL;DR: This analysis localized a second breast cancer susceptibility locus, BRCA2, to a 6-centimorgan interval on chromosome 13q12-13, which preliminary evidence suggests suggests confers a high risk of breast cancer but does not confer a substantially elevated risk of ovarian cancer.
Journal ArticleDOI
Multifactorial Analysis of Differences Between Sporadic Breast Cancers and Cancers Involving BRCA1 and BRCA2 Mutations
Sunil R. Lakhani,Jocelyne Jacquemier,John P. Sloane,Barry A. Gusterson,Thomas J. Anderson,Marc J. van de Vijver,Linda M. Farid,Deon J. Venter,A C Antoniou,Amy Storfer-Isser,Elizabeth Smyth,C. Michael Steel,Neva E. Haites,Rodney J. Scott,David E. Goldgar,Susan L. Neuhausen,Peter A. Daly,Wilma Ormiston,Ross McManus,Siegfried Scherneck,Bruce A.J. Ponder,Debbie Ford,Julian Peto,Dominique Stoppa-Lyonnet,Yves-Jean Bignon,J. P. Struewing,Nigel K. Spurr,D. Timothy Bishop,J. G. M. Klijn,Peter Devilee,Cornelisse J. Cornelisse,Christine Lasset,Gilbert M. Lenoir,Rosa B. Barkardottir,Valgurdur Egilsson,Ute Hamann,Jenny Chang-Claude,Hagay Sobol,Barbara L. Weber,Michael R. Stratton,Douglas F. Easton +40 more
TL;DR: Key features of the histologic phenotypes of breast cancers in carriers of mutant BRCA1 and BRCa2 genes are identified and this information may improve the classification of breast cancer in individuals with a family history of the disease and may ultimately aid in the clinical management of patients.
Journal ArticleDOI
Localization to Xq27 of a susceptibility gene for testicular germ-cell tumours.
Elizabeth A. Rapley,Gillian P. Crockford,Dawn Teare,Patrick J. Biggs,Sheila Seal,Rita Barfoot,S. Edwards,Rifat Hamoudi,Ketil Heimdal,Sophie D. Fosså,Katherine L. Tucker,Jenny Donald,Felicity Collins,Michael Friedlander,David Hogg,Paul E. Goss,Axel Heidenreich,Wilma Ormiston,Peter A. Daly,David Forman,R. Timothy D. Oliver,Michael Leahy,Robert Huddart,Colin Cooper,Julia G. Bodmer,Douglas F. Easton,Michael R. Stratton,D. Timothy Bishop +27 more
TL;DR: The results provide evidence for a TGCT susceptibility gene on chromosome Xq27 that may also predispose to UDT, and collected samples from 134 families with two or more cases of TGCT, 87 of which are affected sibpairs.
Journal Article
Consistent loss of the wild type allele in breast cancers from a family linked to the BRCA2 gene on chromosome 13q12-13.
N. Collins,Ross McManus,Richard Wooster,Jon Mangion,Sheila Seal,Lakhani,Wilma Ormiston,Peter A. Daly,D Ford,Douglas F. Easton +9 more
TL;DR: The data suggest that both alleles of BRCA2 are inactivated in cancers, the pattern expected of a recessive oncogene or tumour suppressor gene.
Journal Article
The pathology of familial breast cancer: histological features of cancers in families not attributable to mutations in BRCA1 or BRCA2.
Sunil R. Lakhani,Barry A. Gusterson,Jocelyne Jacquemier,John P. Sloane,Thomas J. Anderson,Marc J. van de Vijver,Deon J. Venter,Deon J. Venter,Alex Freeman,A C Antoniou,Lesley McGuffog,Elizabeth Smyth,C. Michael Steel,Neva E. Haites,Rodney J. Scott,David E. Goldgar,Susan L. Neuhausen,Peter A. Daly,Wilma Ormiston,Ross McManus,Siegfried Scherneck,Bruce A.J. Ponder,P. Andrew Futreal,Julian Peto,Dominique Stoppa-Lyonnet,Yves-Jean Bignon,Jeffery P. Struewing,D. Timothy Bishop,J.G.M. Klijn,Peter Devilee,Cees J. Cornelisse,Christine Lasset,Gilbert M. Lenoir,Rosa B. Barkardottir,Valgardur Egilsson,Ute Hamann,Jenny Chang-Claude,Hagay Sobol,Barbara L. Weber,Douglas F. Easton,Michael R. Stratton +40 more
TL;DR: The results indicate that non-BRCA1/2 breast cancers differ histologically from both BRC a1 and BRCA 2 breast cancers and are overall of lower grade, and suggest thatNon-B RCA 1/2 Breast cancers differ from nonfamilial breast cancers, but these differences may be attributable to various types of bias.