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Wilson J. Angerson

Bio: Wilson J. Angerson is an academic researcher from Glasgow Royal Infirmary. The author has contributed to research in topics: Colorectal cancer & Cancer. The author has an hindex of 28, co-authored 60 publications receiving 3585 citations.


Papers
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Journal ArticleDOI
TL;DR: A score based on the combination of the systemic inflammatory response and albumin hazards ratio (HR) was comparable in prognostic value to that based on stage and performance status in patients with inoperable non-small-cell lung cancer.
Abstract: A score based on the combination of the systemic inflammatory response and albumin hazards ratio (HR) 1.70, 95% CI 1.23 - 2.35, P=0.001) was comparable in prognostic value to that based on stage and performance status (HR 1.48, 95% CI 1.12 - 1.95, P=0.006) in patients with inoperable non-small-cell lung cancer. The former is simple to measure and well standardised.

619 citations

Journal ArticleDOI
TL;DR: The results of the present study indicate that the GPS, before surgery, predicts overall and cancer-specific survival after resection of colon and rectal cancer.
Abstract: Background/aims The aim of the study was to examine the value of the combination of an elevated C-reactive protein and hypoalbuminaemia (GPS) in predicting cancer-specific survival after resection for colon and rectal cancer.

436 citations

Journal ArticleDOI
TL;DR: The value of an inflammation-based prognostic score was compared with performance status (ECOG) in patients receiving platinum-based chemotherapy for inoperable non-small-cell lung cancer and only the GPS was a significant independent predictor of survival.
Abstract: The value of an inflammation-based prognostic score (GPS) was compared with performance status (ECOG) in patients (n=109) receiving platinum-based chemotherapy for inoperable non-small-cell lung cancer. On multivariate analysis with ECOG, white cell count and the GPS entered as covariates, only the GPS was a significant independent predictor of survival (HR 1.88, 95% CI 1.25–2.84, P=0.002).

315 citations

Journal ArticleDOI
TL;DR: It is indicated that in advanced cancer patients the presence of a systemic inflammatory response and the magnitude of that response predict the duration of cancer-specific and non-cancer survival.
Abstract: The assessment of prognosis in patients with advanced cancer remains problematical. The value of C-reactive protein concentration in this context has not been clearly defined. Patients with a diagnosis of colorectal (n = 182), gastric (n = 87), breast (n = 99), or bronchogenic (n = 404) cancer and who had measurements of C-reactive protein and albumin were identified. Median survival, from the time of sampling, ranged from 478 days in the colorectal cancer patients to 60 days in patients with bronchogenic cancer. On univariate analysis, there was, in each tumor type, a significant relationship between the duration of survival and both log10 C-reactive protein and albumin concentrations (P ? 0.0002). On multivariate analysis, in each tumor type, log10 C-reactive protein remained a significant independent predictor of survival (P ? 0.0002). When all four groups of cancer patients were analyzed (n = 772), the hazard ratio for a 10-fold increase in C-reactive protein concentration in cancer-specific survival ...

241 citations

Journal ArticleDOI
TL;DR: Preliminary results suggest CE-IOUS is an essential tool prior to liver resection for metastases, significantly more sensitive than CT/MR and IOUS in detecting liver metastases.
Abstract: Objective: The aim of the study was to assess the clinical value of contrast-enhanced intraoperative ultrasound (CE-IOUS) as a novel tool in the hepatic staging of patients undergoing liver resection.

194 citations


Cited by
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Journal ArticleDOI
TL;DR: The evidence that indicates that the distribution of many anticancer drugs in tumours is incomplete is summarized, and strategies that might be used either to improve drug penetration through tumour tissue or to select compounds based on their abilities to penetrate tissue are suggested, thereby increasing the therapeutic index.
Abstract: To be most effective anticancer drugs must penetrate tissue efficiently, reaching all the cancer cells that comprise the target population in a concentration sufficient to exert a therapeutic effect. Most research into the resistance of cancers to chemotherapy has concentrated on molecular mechanisms of resistance, whereas the role of limited drug distribution within tumours has been neglected. We summarize the evidence that indicates that the distribution of many anticancer drugs in tumour tissue is incomplete, and we suggest strategies that might be used either to improve drug penetration through tumour tissue or to select compounds based on their abilities to penetrate tissue, thereby increasing the therapeutic index.

2,411 citations

Journal ArticleDOI
TL;DR: A wide range of natural-origin polymers with special focus on proteins and polysaccharides that are being used in research, or might be potentially useful as carriers systems for active biomolecules or as cell carriers with application in the tissue engineering field targeting several biological tissues are overviewed.

1,269 citations

Journal ArticleDOI
TL;DR: These liver CEUS guidelines and recommendations are intended to create standard protocols for the use and administration of UCA in liver applications on an international basis and improve the management of patients worldwide.
Abstract: Initially, a set of guidelines for the use of ultrasound contrast agents was published in 2004 dealing only with liver applications. A second edition of the guidelines in 2008 reflected changes in the available contrast agents and updated the guidelines for the liver, as well as implementing some non-liver applications. Time has moved on, and the need for international guidelines on the use of CEUS in the liver has become apparent. The present document describes the third iteration of recommendations for the hepatic use of contrast enhanced ultrasound (CEUS) using contrast specific imaging techniques. This joint WFUMB-EFSUMB initiative has implicated experts from major leading ultrasound societies worldwide. These liver CEUS guidelines are simultaneously published in the official journals of both organizing federations (i.e., Ultrasound in Medicine and Biology for WFUMB and Ultraschall in der Medizin/European Journal of Ultrasound for EFSUMB). These guidelines and recommendations provide general advice on the use of all currently clinically available ultrasound contrast agents (UCA). They are intended to create standard protocols for the use and administration of UCA in liver applications on an international basis and improve the management of patients worldwide.

1,042 citations

Journal ArticleDOI
TL;DR: The GPS/mGPS is the most extensively validated of the systemic inflammation-based prognostic scores and therefore may be used in the routine clinical assessment of patients with cancer and provides a well defined therapeutic target for future clinical trials.

1,039 citations