W
Wilson Khoo
Researcher at Ontario Institute for Cancer Research
Publications - 8
Citations - 8705
Wilson Khoo is an academic researcher from Ontario Institute for Cancer Research. The author has contributed to research in topics: Apoptosis & Signal transduction. The author has an hindex of 8, co-authored 8 publications receiving 8446 citations. Previous affiliations of Wilson Khoo include Amgen.
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Journal ArticleDOI
OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis
Young-Yun Kong,Hiroki Yoshida,Ildiko Sarosi,Hong-Lin Tan,Emma Timms,Casey Capparelli,Sean Morony,Antonio J. Oliveira-dos-Santos,Gwyneth Van,Annick Itie,Wilson Khoo,Andrew Wakeham,Colin R. Dunstan,David L. Lacey,Tak W. Mak,William J. Boyle,Josef M. Penninger +16 more
TL;DR: OPGL is a new regulator of lymph-node organogenesis and lymphocyte development and is an essential osteoclast differentiation factor in vivo.
Journal ArticleDOI
Differential requirement for caspase 9 in apoptotic pathways in vivo
Razqallah Hakem,Razqallah Hakem,Anne Hakem,Anne Hakem,Gordon S. Duncan,Gordon S. Duncan,Jeffrey T. Henderson,Minna Woo,Minna Woo,Maria S. Soengas,Andrew E. H. Elia,Andrew E. H. Elia,José Luis de la Pompa,José Luis de la Pompa,David Kägi,David Kägi,Wilson Khoo,Wilson Khoo,Julia Potter,Julia Potter,Ritsuko Yoshida,Ritsuko Yoshida,Stephen Kaufman,Scott W. Lowe,Josef M. Penninger,Josef M. Penninger,Tak W. Mak,Tak W. Mak +27 more
TL;DR: Comparison of the requirement for Casp9 and Casp3 in different apoptotic settings indicates the existence of at least four different apoptosis pathways in mammalian cells.
Journal ArticleDOI
TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling
Mark A. Lomaga,Wen Chen Yeh,Ildiko Sarosi,Gordon S. Duncan,Caren Furlonger,Alexandra Ho,Sean Morony,Casey Capparelli,Gwyneth Van,Stephen Kaufman,Annette Van Der Heiden,Annick Itie,Andrew Wakeham,Wilson Khoo,Takehiko Sasaki,Zhaodan Cao,Josef M. Penninger,Christopher J. Paige,David L. Lacey,Colin R. Dunstan,William J. Boyle,David V. Goeddel,Tak W. Mak +22 more
TL;DR: It is reported that mice deficient in TNF receptor-associated factor 6 (TRAF6) are osteopetrotic with defects in bone remodeling and tooth eruption due to impaired osteoclast function, and it is demonstrated that TRAF6 is crucial not only in IL-1 and CD40 signaling but also, surprisingly, in LPS signaling.
Journal ArticleDOI
FADD: Essential for Embryo Development and Signaling from Some, But Not All, Inducers of Apoptosis
Wen-Chen Yeh,José Luis de la Pompa,Mila E. McCurrach,Hong-Bing Shu,Andrew J. Elia,Arda Shahinian,Michelle Ng,Andrew Wakeham,Wilson Khoo,Kyran O. Mitchell,Wafik S. El-Deiry,Scott W. Lowe,David V. Goeddel,Tak W. Mak +13 more
TL;DR: CD95, tumor necrosis factor receptor type 1 (TNFR-1), and death receptor 3 (DR3) did not induce apoptosis in FADD-deficient embryonic fibroblasts, whereas DR4, oncogenes E1A and c-myc, and chemotherapeutic agent adriamycin did.
Journal ArticleDOI
Essential contribution of caspase 3/CPP32 to apoptosis and its associated nuclear changes
Minna Woo,Razqallah Hakem,Maria S. Soengas,Gordon S. Duncan,Arda Shahinian,David Kägi,Anne Hakem,Mila E. McCurrach,Wilson Khoo,Stephen Kaufman,Giorgio Senaldi,Tamara Howard,Scott W. Lowe,Tak W. Mak +13 more
TL;DR: Examination of the role of CPP32 in apoptosis using mice, embryonic stem cells, and mouse embryonic fibroblasts deficient for the caspase indicates that CPP 32 is an essential component in apoptotic events that is remarkably system- and stimulus-dependent.