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Wim J.F. van der Vijgh
Researcher at Maastricht University
Publications - 65
Citations - 3498
Wim J.F. van der Vijgh is an academic researcher from Maastricht University. The author has contributed to research in topics: Antioxidant & Mesna. The author has an hindex of 29, co-authored 65 publications receiving 3367 citations. Previous affiliations of Wim J.F. van der Vijgh include VU University Amsterdam & VU University Medical Center.
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Journal ArticleDOI
Vitamin D status and sex hormone binding globulin: Determinants of bone turnover and bone mineral density in elderly women
Marcel E. Ooms,Paul Lips,Jan C. Roos,Wim J.F. van der Vijgh,Corrie Popp-Snijders,P. Dick Bezemer,Lex M. Bouter +6 more
TL;DR: In elderly women, serum 25(OH)D levels below 30 nmol/l are associated with secondary hyperparathyroidism and increased bone turnover, which may reflect the effects of remaining estrogen activity.
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Influence of iron chelation on the antioxidant activity of flavonoids.
Saskia A.B.E. van Acker,Georgette Plemper van Balen,Dirk–Jan van den Berg,Aalt Bast,Wim J.F. van der Vijgh +4 more
TL;DR: For the majority of flavonoids tested, iron chelation does not play a role in the antioxidant activity in microsomal lipid peroxidation, and the IC50 values in the iron-independent LPO assay showed an excellent correlation with the oxidation potentials.
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Dose-Finding and Pharmacokinetic Study of Cisplatin, Gemcitabine, and SU5416 in Patients With Solid Tumors
Bart C. Kuenen,Lee Rosen,Egbert F. Smit,Mandy R.N. Parson,Marcel Levi,Rita Ruijter,Holger Huisman,Marc A. Kedde,Paul Noordhuis,Wim J.F. van der Vijgh,Godefridus J. Peters,Gillian F. Cropp,Paul Scigalla,Klaus Hoekman,Herbert M. Pinedo,Giuseppe Giaccone +15 more
TL;DR: Analysis of variables of the coagulation cascade and of vessel wall activation was performed in three patients and showed significant increases in thrombin generation and endothelial cell perturbation in a treatment cycle-dependent manner.
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The antioxidant activity of phloretin: the disclosure of a new antioxidant pharmacophore in flavonoids
TL;DR: Comparison with structurally related compounds revealed that the antioxidant pharmacophore of phloretin is 2,6-dihydroxyacetophenone, a potent antioxidant activity in peroxynitrite scavenging and the inhibition of lipid peroxidation.
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Flavonoids can replace α-tocopherol as an antioxidant
Frédérique A. A. van Acker,Olga Schouten,Guido R.M.M. Haenen,Wim J.F. van der Vijgh,Aalt Bast +4 more
TL;DR: Introduction of antioxidant flavonoids, such as 7‐monohydroxyethylrutoside, fisetin or naringenin, into the deficient microsomes restored the GSH‐dependent protection, suggesting that flavonoid can take over the role of α‐tocopherol as a chain‐breaking antioxidant in liver microsomal membranes.