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Wing-Kin Sung
Researcher at National University of Singapore
Publications - 335
Citations - 28128
Wing-Kin Sung is an academic researcher from National University of Singapore. The author has contributed to research in topics: Gene & Genome. The author has an hindex of 64, co-authored 327 publications receiving 26116 citations. Previous affiliations of Wing-Kin Sung include University of Hong Kong & Yale University.
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Journal ArticleDOI
Automatic construction of online catalog topologies
TL;DR: This paper proposes a metric, based on the popularity of products and the relative importance of product attribute values, to evaluate the quality of a catalog organization and develops an efficient greedy algorithm, GENCAT, which produces better catalog organizations based on this metric.
Proceedings ArticleDOI
Improved algorithms for constructing consensus trees
TL;DR: New deterministic algorithms for constructing consensus trees that are faster than all the previously known ones are presented.
Journal ArticleDOI
Simultaneously learning DNA motif along with its position and sequence rank preferences through expectation maximization algorithm.
TL;DR: A de novo motif discovery algorithm called SEME (sampling with expectation maximization for motif elicitation), which uses pure probabilistic mixture model to model the motif's binding features and uses expectation maximized algorithms to simultaneously learn the sequence motif, position, and sequence rank preferences without asking for any prior knowledge from the user.
Journal ArticleDOI
Next-Generation Sequencing of Apoptotic DNA Breakpoints Reveals Association with Actively Transcribed Genes and Gene Translocations
Melissa J. Fullwood,Joanne Lee,Lifang Lin,Guoliang Li,Mikael Huss,Patrick Ng,Wing-Kin Sung,Shirish Shenolikar,Shirish Shenolikar +8 more
TL;DR: Next-generation sequencing of DNA fragments generated in Actinomycin D-treated human HL-60 leukemic cells were used to generate a high-throughput, global map of apoptotic DNA breakpoints and highlighted that DNA breaks are non-random and show a significant association with active genes and open chromatin regions.
Journal ArticleDOI
Serine peptidase inhibitor Kazal type 1 (SPINK1) as novel downstream effector of the cadherin-17/β-catenin axis in hepatocellular carcinoma
Felix H. Shek,Felix H. Shek,Ruibang Luo,Brian Y.H. Lam,Wing-Kin Sung,Wing-Kin Sung,Tak-Wah Lam,John M. Luk,Ming Sum Leung,Kin Tak Chan,Hector K. Wang,Chung Man Chan,Chung Man Chan,Ronnie T.P. Poon,Nikki P. Lee,Nikki P. Lee +15 more
TL;DR: The current data substantiate knowledge on the role of CDH17 in the biology of HCC and suggest that components of the CDh17/β-catenin axis may serve as therapeutic targets in CDH 17 over-expressing HCC patients.