Wing-Kin Sung

TL;DR: Functional experiments revealed that certain positively selected genes might enhance mammalian virulence by interacting with host cellular pathways or utilizing host nutrients, and establish Bp as a model system for studying the genetics of accidental virulence.

TL;DR: Different components in the SV calling pipeline are described, the techniques used by existing SV callers are reviewed and it is demonstrated that library properties, especially insert size, greatly impact the sensitivity of different SV caller.

TL;DR: This work cloned the homolog of human LRRK2, characterized its expression, and investigated its biological functions in zebrafish to demonstrate that zL RRK2 is an ortholog of hLRRk2 and that the deletion of WD40 domain of zLRRK 2 provides a disease model for PD.

TL;DR: This work explored the feasibility of an exact solution for scaffolding and presented a first fixed-parameter tractable solution for assembly (Opera), and described a graph contraction procedure that allows the solution to scale to large scaffolding problems.

TL;DR: A deterministic method called ChromSDE is presented, which applies semi-definite programming techniques to find the best structure fitting the observed data and uses golden section search to finding the correct parameter for converting the contact frequency to spatial distance and proves that the parameter of conversion from contact frequencyto spatial distance will change under different resolutions theoretically and empirically.