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Wing-Kin Sung
Researcher at National University of Singapore
Publications - 335
Citations - 28128
Wing-Kin Sung is an academic researcher from National University of Singapore. The author has contributed to research in topics: Gene & Genome. The author has an hindex of 64, co-authored 327 publications receiving 26116 citations. Previous affiliations of Wing-Kin Sung include University of Hong Kong & Yale University.
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Journal ArticleDOI
Whole-genome reconstruction and mutational signatures in gastric cancer
Niranjan Nagarajan,Denis Bertrand,Axel M. Hillmer,Zhi Jiang Zang,Fei Yao,Fei Yao,Pierre-Étienne Jacques,Audrey S.M. Teo,Ioana Cutcutache,Zhenshui Zhang,Wah Heng Lee,Yee Yen Sia,Song Gao,Pramila N. Ariyaratne,Andrea Ho,Xing Yi Woo,Lavanya Veeravali,Choon Kiat Ong,Niantao Deng,Kartiki V. Desai,Chiea Chuen Khor,Chiea Chuen Khor,Martin L. Hibberd,Martin L. Hibberd,Atif Shahab,Jaideepraj Rao,Mengchu Wu,Ming Teh,Feng Zhu,Sze Yung Chin,Brendan Pang,Jimmy Bok Yan So,Guillaume Bourque,Richie Soong,Wing-Kin Sung,Bin Tean Teh,Steven G. Rozen,Xiaoan Ruan,Khay Guan Yeoh,Patrick Tan,Patrick Tan,Yijun Ruan,Yijun Ruan +42 more
TL;DR: This first whole-genome analysis of two gastric adenocarcinomas revealed the architecture of a wild-type KRAS amplification, a common driver event in gastric cancer, and discovered three distinct mutational signatures - against a genome-wide backdrop of oxidative and microsatellite instability-related mutations, the first exome-specific mutational signature is identified.
Journal ArticleDOI
Large-Scale Functional Organization of Long-Range Chromatin Interaction Networks
Kuljeet Singh Sandhu,Guoliang Li,Huay Mei Poh,Yu Ling Kelly Quek,Yu Ling Kelly Quek,Yee Yen Sia,Su Qin Peh,Fabianus Hendriyan Mulawadi,Joanne Lim,Mile Šikić,Francesca Menghi,Anbupalam Thalamuthu,Wing-Kin Sung,Wing-Kin Sung,Xiaoan Ruan,Melissa J. Fullwood,Melissa J. Fullwood,Edison T. Liu,Peter Csermely,Yijun Ruan +19 more
TL;DR: A systems-level evolutionary framework is revealed that shapes functionally compartmentalized and error-tolerant transcriptional regulation of human genome in three dimensions.
Journal ArticleDOI
Recurrent Fusion Genes in Gastric Cancer: CLDN18-ARHGAP26 Induces Loss of Epithelial Integrity
Fei Yao,Fei Yao,Jaya P. Kausalya,Yee Yen Sia,Yee Yen Sia,Audrey S. M. Teo,Audrey S. M. Teo,Wah Heng Lee,Alicia G.M. Ong,Zhenshui Zhang,Joanna H.J. Tan,Guoliang Li,Denis Bertrand,Xingliang Liu,Huay Mei Poh,Peiyong Guan,Peiyong Guan,Feng Zhu,Thushangi Nadeera Pathiraja,Thushangi Nadeera Pathiraja,Pramila N. Ariyaratne,Jaideepraj Rao,Xing Yi Woo,Shaojiang Cai,Fabianus Hendriyan Mulawadi,Wan Ting Poh,Lavanya Veeravalli,Chee Seng Chan,Seong Soo Lim,See Ting Leong,Say Chuan Neo,Poh Sum D Choi,Elaine G.Y. Chew,Niranjan Nagarajan,Pierre-Étienne Jacques,Jimmy Bok Yan So,Jimmy Bok Yan So,Xiaoan Ruan,Khay Guan Yeoh,Khay Guan Yeoh,Patrick Tan,Wing-Kin Sung,Wing-Kin Sung,Walter Hunziker,Walter Hunziker,Yijun Ruan,Axel M. Hillmer,Axel M. Hillmer +47 more
TL;DR: Using DNA paired-end-tag (DNA-PET) whole-genome sequencing, 15 gastric cancers from Southeast Asians were analyzed and recurrent fusions between CLDN18, a tight junction gene, and ARHGAP26, a gene encoding a RHOA inhibitor were found.
Proceedings ArticleDOI
Breaking a time-and-space barrier in constructing full-text indices
TL;DR: These are the first algorithms that achieve 0(n log n) time with optimal working space, under a reasonable assumption that log |A| = o(log n) and the general case where the size of the alphabet A is not constant.
Journal ArticleDOI
Fusion transcripts and transcribed retrotransposed loci discovered through comprehensive transcriptome analysis using Paired-End diTags (PETs)
Yijun Ruan,Hong Sain Ooi,Siew Woh Choo,Kuo Ping Chiu,Xiao Dong Zhao,Kandhadayar G. Srinivasan,Fei Yao,Chiou Yu Choo,Jun Liu,Pramila N. Ariyaratne,Wilson G.W. Bin,Vladimir A. Kuznetsov,Atif Shahab,Wing-Kin Sung,Guillaume Bourque,Nallasivam Palanisamy,Chia-Lin Wei +16 more
TL;DR: Using the PET approach for comprehensive transcriptome analysis, the PET mapping strategy presented here promises to be a useful tool in annotating the human genome, especially aberrations in human cancer genomes.