Witold Filipowicz

TL;DR: This Review summarizes the current understanding of the mechanistic aspects of microRNA-induced repression of translation and discusses some of the controversies regarding different modes of micro RNA function.

TL;DR: This work has shown that the regulation of miRNA metabolism and function by a range of mechanisms involving numerous protein–protein and protein–RNA interactions has an important role in the context-specific functions of miRNAs.

TL;DR: In this article, the authors describe principles of miRNA-mRNA interactions and proteins that interact with miRNAs and function in miRNA mediated repression, and discuss the multiple, often contradictory, mechanisms that miRNA have been reported to use, which cause translational repression and mRNA decay.

TL;DR: It is demonstrated that endogenous let-7 microribonucleoproteins (miRNPs) or the tethering of Argonaute proteins to reporter mRNAs in human cells inhibit translation initiation, suggesting that miRNPs interfere with recognition of the cap.

TL;DR: This work shows that cationic amino acid transporter 1 (CAT-1) mRNA and reporters bearing its 3'UTR can be relieved from the microRNA miR-122-induced inhibition in human hepatocarcinoma cells subjected to different stress conditions and proposes that proteins interacting with the 3'utR will generally act as modifiers altering the potential of miRNAs to repress gene expression.