W
Wolfgang A. Linke
Researcher at University of Münster
Publications - 212
Citations - 16888
Wolfgang A. Linke is an academic researcher from University of Münster. The author has contributed to research in topics: Titin & Myofibril. The author has an hindex of 68, co-authored 189 publications receiving 14247 citations. Previous affiliations of Wolfgang A. Linke include Mayo Clinic & Heidelberg University.
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Journal ArticleDOI
Cardioprotection and lifespan extension by the natural polyamine spermidine
Tobias Eisenberg,Mahmoud Abdellatif,Sabrina Schroeder,Uwe Primessnig,Uwe Primessnig,Slaven Stekovic,Tobias Pendl,Alexandra Harger,Alexandra Harger,Julia Schipke,Andreas Zimmermann,Albrecht Schmidt,Mingming Tong,Christoph Ruckenstuhl,Christopher Dammbrueck,Angelina S. Gross,Viktoria Herbst,Christoph Magnes,Gert Trausinger,Sophie H. Narath,Andreas Meinitzer,Zehan Hu,Zehan Hu,Alexander H. Kirsch,Kathrin Eller,Didac Carmona-Gutierrez,Sabrina Büttner,Sabrina Büttner,Federico Pietrocola,Oskar Knittelfelder,Emilie Schrepfer,Patrick Rockenfeller,Patrick Rockenfeller,Corinna Simonini,Alexandros Rahn,Marion Horsch,Kristin Moreth,Johannes Beckers,Helmut Fuchs,Valerie Gailus-Durner,Frauke Neff,Dirk Janik,Birgit Rathkolb,Jan Rozman,Martin Hrabé de Angelis,Tarek Moustafa,Tarek Moustafa,Guenter Haemmerle,Manuel Mayr,Peter Willeit,Peter Willeit,Marion von Frieling-Salewsky,Burkert Pieske,Burkert Pieske,Luca Scorrano,Thomas R. Pieber,Thomas R. Pieber,Raimund Pechlaner,Johann Willeit,Stephan J. Sigrist,Stephan J. Sigrist,Wolfgang A. Linke,Christian Mühlfeld,Junichi Sadoshima,Joern Dengjel,Joern Dengjel,Stefan Kiechl,Guido Kroemer,Simon Sedej,Frank Madeo +69 more
TL;DR: It is shown that oral supplementation of the natural polyamine spermidine extends the lifespan of mice and exerts cardioprotective effects, reducing cardiac hypertrophy and preserving diastolic function in old mice, and suggests a new and feasible strategy for protection against cardiovascular disease.
Journal ArticleDOI
Myocardial structure and function differ in systolic and diastolic heart failure.
Loek van Heerebeek,Attila Borbély,Hans W.M. Niessen,Jean G.F. Bronzwaer,Jolanda van der Velden,Ger J.M. Stienen,Wolfgang A. Linke,Gerrit J Laarman,Walter Paulus +8 more
TL;DR: LV myocardial structure and function differ in SHF and DHF because of distinct cardiomyocyte abnormalities, and these findings support the clinical separation of heart failure patients into SHF or DHF phenotypes.
Journal ArticleDOI
Reverse engineering of the giant muscle protein titin
Hongbin Li,Wolfgang A. Linke,Andres F. Oberhauser,Mariano Carrión-Vázquez,Jason Kerkvliet,Hui Lu,Piotr E. Marszalek,Julio M. Fernandez +7 more
TL;DR: This work uses protein engineering and single-molecule atomic force microscopy to examine the mechanical components that form the elastic region of human cardiac titin and shows the functional reconstitution of a protein from the sum of its parts.
Journal ArticleDOI
Titin mutations in iPS cells define sarcomere insufficiency as a cause of dilated cardiomyopathy
John T. Hinson,Anant Chopra,N. Nafissi,William J. Polacheck,William J. Polacheck,Craig C. Benson,Sandra Swist,Joshua M. Gorham,Luhan Yang,Sebastian Schafer,Calvin C. Sheng,Alireza Haghighi,Jason Homsy,Norbert Hubner,George M. Church,George M. Church,Stuart A. Cook,Wolfgang A. Linke,Christopher S. Chen,Christopher S. Chen,Jonathan G. Seidman,Christine E. Seidman,Christine E. Seidman,Christine E. Seidman +23 more
TL;DR: Cardiac microtissues engineered from human induced pluripotent stem (iPS) cells are a powerful system for evaluating the pathogenicity of titin gene variants and it is found that certain missense mutations, like TTNtvs, diminish contractile performance and are pathogenic.
Journal ArticleDOI
Defined Engineered Human Myocardium With Advanced Maturation for Applications in Heart Failure Modeling and Repair.
Malte Tiburcy,James E. Hudson,Paul Balfanz,Susanne F. Schlick,Tim Meyer,Mei-Ling Chang Liao,Elif Levent,Farah Raad,Sebastian Zeidler,Edgar Wingender,Johannes Riegler,Mouer Wang,Joseph D. Gold,Izhak Kehat,Erich Wettwer,Ursula Ravens,Pieterjan Dierickx,Linda W. van Laake,Marie-José Goumans,Sara Khadjeh,Karl Toischer,Gerd Hasenfuss,Larry A. Couture,Andreas Unger,Wolfgang A. Linke,Toshiyuki Araki,Benjamin G. Neel,Gordon Keller,Lior Gepstein,Joseph C. Wu,Wolfram-Hubertus Zimmermann +30 more
TL;DR: A proof-of-concept for a universally applicable technology for the engineering of macroscale human myocardium for disease modeling and heart repair from embryonic and induced pluripotent stem cell–derived cardiomyocytes under defined, serum-free conditions is provided.