Author
Wolfgang Dohle
Other affiliations: Ludwig Maximilian University of Munich, University of Bristol
Bio: Wolfgang Dohle is an academic researcher from University of Bath. The author has contributed to research in topics: Chemistry & Medicine. The author has an hindex of 18, co-authored 38 publications receiving 2289 citations. Previous affiliations of Wolfgang Dohle include Ludwig Maximilian University of Munich & University of Bristol.
Topics: Chemistry, Medicine, Aryl, 2-Methoxyestradiol, Tetrahydroisoquinoline
Papers
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TL;DR: Recently, the halogen-magnesium exchange has considerably extended the range of functionalized Grignard reagents available for synthetic purposes and new applications of organomagnesium reagents in cross-coupling reactions and amination reactions will be covered in this Review.
Abstract: Organomagnesium reagents occupy a central position in synthetic organic and organometallic chemistry. Recently, the halogen-magnesium exchange has considerably extended the range of functionalized Grignard reagents available for synthetic purposes. Functional groups such as esters, nitriles, iodides, imines, or even nitro groups can be present in a wide range of aromatic and heterocyclic organomagnesium reagents. Also various highly functionalized alkenyl magnesium species can be prepared. These recent developments as well as new applications of organomagnesium reagents in cross-coupling reactions and amination reactions will be covered in this Review.
660 citations
TL;DR: The continuous flow reactor was shown to be superior to a batch reactor for performing a problematic photochemical reaction on a larger scale and to be capable of producing >500 g of 2 and 175 g of 4 in a continuous 24 h processing period.
Abstract: Compact flow reactors have been constructed and optimized to perform continuous organic photochemistry on a large scale. The reactors were constructed from commercially available or customized imme...
318 citations
TL;DR: A general preparation of 2-substituted indoles starting from functionalized 2-alkynylanilines has been developed and this base mediated reaction has been used to synthesize the heterocyclic core of the marine alkaloid hinckdentine A.
222 citations
193 citations
TL;DR: In this article, the authors ermoglicht der Halogen-Magnesium-Austausch den Zugang zu ainer Reihe funktionalisierter Grignard-Reagentien.
Abstract: Magnesiumverbindungen spielen eine zentrale Rolle in der praparativen organischen und metallorganischen Chemie. Seit kurzem ermoglicht der Halogen-Magnesium-Austausch den Zugang zu einer Reihe funktionalisierter Grignard-Reagentien. Ester-, Nitril-, Iod- und Iminfunktionen und sogar Nitrogruppen konnen in einer breiten Reihe aromatischer und heterocyclischer Organomagnesiumverbindungen vorhanden sein. Auch hoch funktionalisierte Alkenylmagnesiumspezies konnen auf diese Weise generiert werden. Diese neuen Entwicklungen sowie die Anwendung von Organomagnesiumreagentien in Kreuzkupplungen und Aminierungsreaktionen werden in diesem Aufsatz eingehend beschrieben.
193 citations
Cited by
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TL;DR: Pd on Modified Silica 159 4.5.1.
Abstract: 4.4. Pd on Modified Silica 159 4.5. Pd on Clay and Other Inorganic Materials 159 5. Stille, Fukuyama, and Negishi Reactions 159 5.1. Stille Reactions 159 5.1.1. Pd on Carbon (Pd/C) 159 5.1.2. Palladium on KF/Al2O3 159 5.1.3. Pd on Modified Silica (SiO2/TEG/Pd) 159 5.2. Fukuyama Reactions 159 5.2.1. Pd on Carbon (Pd/C) 159 5.2.2. Pd(OH)2 on Carbon (Perlman’s Catalyst) 160 5.3. Pd/C-Catalyzed Negishi Reactions 160 6. Ullmann-Type Coupling Reactions 161 6.1. Pd/C-Catalyzed Aryl−Aryl Coupling 161 6.2. Pd/C-Catalyzed Homocoupling of Vinyl Halides 162
1,900 citations
1,777 citations
TL;DR: Hydroamination of Alkenes and Alkynes under Microwave Irradiation and Nitromercuration Reactions 3878 9.8.4.5.
Abstract: 8.4.5. Nitromercuration Reactions 3878 9. Hydroamination of Alkenes and Alkynes under Microwave Irradiation 3878 * To whom correspondence should be addressed. Phone: +49 241 8
1,685 citations
1,637 citations
TL;DR: This review introduces readers to the basic principles and fundamentals of flow chemistry and critically discusses recent flow chemistry accounts.
Abstract: Flow chemistry involves the use of channels or tubing to conduct a reaction in a continuous stream rather than in a flask Flow equipment provides chemists with unique control over reaction parameters enhancing reactivity or in some cases enabling new reactions This relatively young technology has received a remarkable amount of attention in the past decade with many reports on what can be done in flow Until recently, however, the question, “Should we do this in flow?” has merely been an afterthought This review introduces readers to the basic principles and fundamentals of flow chemistry and critically discusses recent flow chemistry accounts
1,192 citations