Wolfgang Engel

TL;DR: The presence of not one but three spermatogenesis loci in Yq11 is proposed and that each locus is active during a different phase of male germ cell development.

TL;DR: Guan et al. as discussed by the authors used genetic selection to isolate adult spermatogonial stem cells (SSCs) from adult mouse testis using a success rate of 27%.

TL;DR: In this paper, the authors used genetic selection to isolate adult spermatogonial stem cells (SSCs) from adult mouse testis using a success rate of 27% and found that these isolated SSCs respond to culture conditions and acquire embryonic stem cell properties.

TL;DR: It is shown that male mice homozygous for a targeted deletion of the Insl3 locus exhibit bilateral cryptorchidism with free moving testes and genital ducts, due to failure of gubernaculum development during embryogenesis, and that androgen-mediated regression of the CSL occurs independently from InSl3.

TL;DR: This approach provides an accessible in vitro model system for studies of mammalian gametogenesis, as well as for the development of new strategies for the generation of transgenic mice and treatment of infertility.