Wolfgang Langhans

TL;DR: The numerous beneficial effects of GLP-1 render this hormone an interesting candidate for the development of pharmacotherapies to treat obesity, diabetes, and neurodegenerative disorders.

TL;DR: Analysis of cardiovascular parameters indicates a positive relationship between amylase and sympathetic tone (LF/HF) during stress, and salivary alpha-amylase may be a useful additional parameter for the measurement of stress.

TL;DR: The results presented here do not support a role of the obestatin/GPR-39 system in the regulation of energy balance, and it is concluded that ghrelin stimulates food intake and adiposity and thereby increases body weight in rodents after central as well as peripheral administration.

TL;DR: Hormones of the endocrine pancreas are collectively at the crossroads of many aspects of energy homeostasis, and glucagon and amylin act in the short term to reduce meal size, and insulin sensitizes the brain to short-term meal-generated satiety signals; and insulin and perhaps amyl in as well act over longer intervals to modulate the amount of fat maintained and defended by the brain.

TL;DR: The data indicate that peripherally infused GLP-1 acutely and specifically reduces the size of ongoing meals in rats and that the satiating effect of ip, but not iv, GLp-1 requires vagal afferent signaling, and suggest that iv GLP -1 infusions do not inhibit eating via hepatic portal or hepatic GLP1 receptors but may act directly on the brain.