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Showing papers by "Wolfgang Wagner published in 2017"



Journal ArticleDOI
Morad Aaboud, Alexander Kupco1, Peter Davison2, Samuel Webb3  +2944 moreInstitutions (220)
TL;DR: In this article, a search for new resonant and non-resonant high-mass phenomena in dielectron and dimuon fi nal states was conducted using 36 : 1 fb(-1) of proton-proton collision data.
Abstract: A search is conducted for new resonant and non-resonant high-mass phenomena in dielectron and dimuon fi nal states. The search uses 36 : 1 fb(-1) of proton-proton collision data, collected at root ...

329 citations


Journal ArticleDOI
TL;DR: In just the past five years, the field of Earth observation has progressed beyond the offerings of conventional space agency based platforms to include a plethora of sensing opportunities afforded by CubeSats, Unmanned Aerial Vehicles, and smartphone technologies that are being embraced by both for-profit companies and individual researchers.
Abstract: In just the past five years, the field of Earth observation has progressed beyond the offerings of conventional space agency based platforms to include a plethora of sensing opportunities afforded by CubeSats, Unmanned Aerial Vehicles (UAVs), and smartphone technologies that are being embraced by both for-profit companies and individual researchers. Over the previous decades, space agency efforts have brought forth well-known and immensely useful satellites such as the Landsat series and the Gravity Research and Climate Experiment (GRACE) system, with costs typically on the order of one billion dollars per satellite and with concept-to-launch timelines on the order of two decades (for new missions). More recently, the proliferation of smartphones has helped to miniaturise sensors and energy requirements, facilitating advances in the use of CubeSats that can be launched by the dozens, while providing ultra-high (3-5 m) resolution sensing of the Earth on a daily basis. Start-up companies that did not exist five years ago now operate more satellites in orbit than any space agency, and at costs that are a mere fraction of the cost of traditional satellite missions. With these advances come new space-borne measurements, such as real-time high-definition video for tracking air pollution, storm-cell development, flood propagation, precipitation monitoring, or even for constructing digital surfaces using structure-from-motion techniques. Closer to the surface, measurements from small unmanned drones and tethered balloons have mapped snow depths, floods, and estimated evaporation at sub-meter resolutions, pushing back on spatio-temporal constraints and delivering new process insights. At ground level, precipitation has been measured using signal attenuation between antennae mounted on cell phone towers, while the proliferation of mobile devices has enabled citizen-scientists to catalogue photos of environmental conditions, estimate daily average temperatures from battery state, and sense other hydrologically important variables such as channel depths using commercially available wireless devices. Global internet access is being pursued via high altitude balloons, solar planes, and hundreds of planned satellite launches, providing a means to exploit the Internet of Things as an entirely new measurement domain. Such global access will enable real-time collection of data from billions of smartphones or from remote research platforms. This future will produce petabytes of data that can only be accessed via cloud storage and will require new analytical approaches to interpret. The extent to which today's hydrologic models can usefully ingest such massive data volumes is unclear. Nor is it clear whether this deluge of data will be usefully exploited, either because the measurements are superfluous, inconsistent, not accurate enough, or simply because we lack the capacity to process and analyse them. What is apparent is that the tools and techniques afforded by this array of novel and game-changing sensing platforms present our community with a unique opportunity to develop new insights that advance fundamental aspects of the hydrological sciences. To accomplish this will require more than just an application of the technology: in some cases, it will demand a radical rethink on how we utilise and exploit these new observing systems to enhance our understanding of the Earth and its linked processes.

319 citations


Journal ArticleDOI
Morad Aaboud, Georges Aad1, Brad Abbott2, Jalal Abdallah3  +2906 moreInstitutions (214)
TL;DR: In this paper, Dijet events are studied in the proton-proton collision dataset recorded at root s = 13 TeV with the ATLAS detector at the Large Hadron Collider in 2015 and 2016.
Abstract: Dijet events are studied in the proton-proton collision dataset recorded at root s = 13 TeV with the ATLAS detector at the Large Hadron Collider in 2015 and 2016, corresponding to integrated lumino ...

248 citations


Journal ArticleDOI
TL;DR: Results show that the -value classification provides a robust basis for decisions regarding using either active or passive data alone, or an unweighted average in cases where relative weights cannot be estimated reliably, and that the weights estimated from TCA in almost all cases outperform the ternary decision upon which the ESA CCI SM v02.3 is based.
Abstract: We propose a method for merging soil moisture retrievals from spaceborne active and passive microwave instruments based on weighted averaging taking into account the error characteristics of the individual data sets. The merging scheme is parameterized using error variance estimates obtained from using triple collocation analysis (TCA). In regions where TCA is deemed unreliable, we use correlation significance levels ( $p$ -values) as indicator for retrieval quality to decide whether to use active data only, passive data only, or an unweighted average. We apply the proposed merging scheme to active retrievals from advanced scatterometer and passive retrievals from the Advanced Microwave Scanning Radiometer—Earth Observing System using Global Land Data Assimilation System-Noah to complement the triplet required for TCA. The merged time series is evaluated against soil moisture estimates from ERA-Interim/Land and in situ measurements from the International Soil Moisture Network using the European Space Agency’s (ESA’s) current Climate Change Initiative—Soil Moisture (ESA CCI SM) product version v02.3 as benchmark merging scheme. Results show that the $p$ -value classification provides a robust basis for decisions regarding using either active or passive data alone, or an unweighted average in cases where relative weights cannot be estimated reliably, and that the weights estimated from TCA in almost all cases outperform the ternary decision upon which the ESA CCI SM v02.3 is based. The proposed method forms the basis for the new ESA CCI SM product version v03.x and higher.

240 citations


Journal ArticleDOI
Morad Aaboud, Georges Aad1, Brad Abbott2, Jalal Abdallah3  +2843 moreInstitutions (197)
TL;DR: The algorithm removes calorimeter energy deposits due to charged hadrons from consideration during jet reconstruction, instead using measurements of their momenta from the inner tracker, which improves the accuracy of the charged-hadron measurement, while retaining the calorimeters' measurements of neutral-particle energies.
Abstract: This paper describes the implementation and performance of a particle flow algorithm applied to 20.2 fb(-1) of ATLAS data from 8 TeV proton-proton collisions in Run 1 of the LHC. The algorithm remo ...

125 citations


Journal ArticleDOI
TL;DR: It is demonstrated that groove-ridge structures with a periodicity in the submicrometer range induce elongation of iPSC colonies, guide the orientation of apical actin fibers, and direct the polarity of cell division.
Abstract: The relevance of topographic cues for commitment of induced pluripotent stem cells (iPSCs) is largely unknown. In this study, we demonstrate that groove-ridge structures with a periodicity in the submicrometer range induce elongation of iPSC colonies, guide the orientation of apical actin fibers, and direct the polarity of cell division. Elongation of iPSC colonies impacts also on their intrinsic molecular patterning, which seems to be orchestrated from the rim of the colonies. BMP4-induced differentiation is enhanced in elongated colonies, and the submicron grooves impact on the spatial modulation of YAP activity upon induction with this morphogen. Interestingly, TAZ, a YAP paralog, shows distinct cytoskeletal localization in iPSCs. These findings demonstrate that topography can guide orientation and organization of iPSC colonies, which may affect the interaction between mechanosensors and mechanotransducers in iPSCs.

118 citations


Journal ArticleDOI
Morad Aaboud, Georges Aad1, Brad Abbott2, Jalal Abdallah3  +2846 moreInstitutions (198)
TL;DR: Results of a search for physics beyond the Standard Model in events containing an energetic photon and large missing transverse momentum with the ATLAS detector at the Large Hadron Collider are reported, with model-independent limits set on the fiducial cross section.
Abstract: Results of a search for physics beyond the Standard Model in events containing an energetic photon and large missing transverse momentum with the ATLAS detector at the Large Hadron Collider are rep ...

115 citations


Journal ArticleDOI
TL;DR: This study first performs a review of the climatic, meteorological, and hydrological studies that use satellite soil moisture products for a better understanding of the water and energy cycle and the strengths and limitations of ASCAT soil moisture Products.
Abstract: Remote sensing of soil moisture has reached a level of good maturity and accuracy for which the retrieved products are ready to use in real-world applications. Due to the importance of soil moisture in the partitioning of the water and energy fluxes between the land surface and the atmosphere, a wide range of applications can benefit from the availability of satellite soil moisture products. Specifically, the Advanced SCATterometer (ASCAT) on board the series of Meteorological Operational (Metop) satellites is providing a near real time (and long-term, 9+ years starting from January 2007) soil moisture product, with a nearly daily (sub-daily after the launch of Metop-B) revisit time and a spatial sampling of 12.5 and 25 km. This study first performs a review of the climatic, meteorological, and hydrological studies that use satellite soil moisture products for a better understanding of the water and energy cycle. Specifically, applications that consider satellite soil moisture product for improving their predictions are analyzed and discussed. Moreover, four real examples are shown in which ASCAT soil moisture observations have been successfully applied toward: 1) numerical weather prediction, 2) rainfall estimation, 3) flood forecasting, and 4) drought monitoring and prediction. Finally, the strengths and limitations of ASCAT soil moisture products and the way forward for fully exploiting these data in real-world applications are discussed.

103 citations


Journal ArticleDOI
TL;DR: In 2016, the dominant greenhouse gases released into Earth's atmosphere-carbon dioxide, methane, and nitrous oxide-continued to increase and reach new record highs as discussed by the authors, and the 3.5 ± 0.1 ppm rise in global annual mean carbon dioxide from 2015 to 2016 was the largest increase observed in the 58-year measurement record.
Abstract: In 2016, the dominant greenhouse gases released into Earth's atmosphere-carbon dioxide, methane, and nitrous oxide-continued to increase and reach new record highs. The 3.5 ± 0.1 ppm rise in global annual mean carbon dioxide from 2015 to 2016 was the largest annual increase observed in the 58-year measurement record. The annual global average carbon dioxide concentration at Earth's surface surpassed 400 ppm (402.9 ± 0.1 ppm) for the first time in the modern atmospheric measurement record and in ice core records dating back as far as 800000 years. One of the strongest El Nino events since at least 1950 dissipated in spring, and a weak La Nina evolved later in the year. Owing at least in part to the combination of El Nino conditions early in the year and a long-term upward trend, Earth's surface observed record warmth for a third consecutive year, albeit by a much slimmer margin than by which that record was set in 2015. Above Earth's surface, the annual lower troposphere temperature was record high according to all datasets analyzed, while the lower stratospheric temperature was record low according to most of the in situ and satellite datasets. Several countries, including Mexico and India, reported record high annual temperatures while many others observed near-record highs. A week-long heat wave at the end of April over the northern and eastern Indian peninsula, with temperatures surpassing 44°C, contributed to a water crisis for 330 million people and to 300 fatalities. In the Arctic the 2016 land surface temperature was 2.0°C above the 1981-2010 average, breaking the previous record of 2007, 2011, and 2015 by 0.8°C, representing a 3.5°C increase since the record began in 1900. The increasing temperatures have led to decreasing Arctic sea ice extent and thickness. On 24 March, the sea ice extent at the end of the growth season saw its lowest maximum in the 37-year satellite record, tying with 2015 at 7.2% below the 1981-2010 average. The September 2016 Arctic sea ice minimum extent tied with 2007 for the second lowest value on record, 33% lower than the 1981-2010 average. Arctic sea ice cover remains relatively young and thin, making it vulnerable to continued extensive melt. The mass of the Greenland Ice Sheet, which has the capacity to contribute ∼7 m to sea level rise, reached a record low value. The onset of its surface melt was the second earliest, after 2012, in the 37-year satellite record. Sea surface temperature was record high at the global scale, surpassing the previous record of 2015 by about 0.01°C. The global sea surface temperature trend for the 21st centuryto-date of +0.162°C decade-1 is much higher than the longer term 1950-2016 trend of +0.100°C decade-1. Global annual mean sea level also reached a new record high, marking the sixth consecutive year of increase. Global annual ocean heat content saw a slight drop compared to the record high in 2015. Alpine glacier retreat continued around the globe, and preliminary data indicate that 2016 is the 37th consecutive year of negative annual mass balance. Across the Northern Hemisphere, snow cover for each month from February to June was among its four least extensive in the 47-year satellite record. Continuing a pattern below the surface, record high temperatures at 20-m depth were measured at all permafrost observatories on the North Slope of Alaska and at the Canadian observatory on northernmost Ellesmere Island. In the Antarctic, record low monthly surface pressures were broken at many stations, with the southern annular mode setting record high index values in March and June. Monthly high surface pressure records for August and November were set at several stations. During this period, record low daily and monthly sea ice extents were observed, with the November mean sea ice extent more than 5 standard deviations below the 1981-2010 average. These record low sea ice values contrast sharply with the record high values observed during 2012-14. Over the region, springtime Antarctic stratospheric ozone depletion was less severe relative to the 1991-2006 average, but ozone levels were still low compared to pre-1990 levels. Closer to the equator, 93 named tropical storms were observed during 2016, above the 1981-2010 average of 82, but fewer than the 101 storms recorded in 2015. Three basins-the North Atlantic, and eastern and western North Pacific-experienced above-normal activity in 2016. The Australian basin recorded its least active season since the beginning of the satellite era in 1970. Overall, four tropical cyclones reached the Saffir-Simpson category 5 intensity level. The strong El Nino at the beginning of the year that transitioned to a weak La Nina contributed to enhanced precipitation variability around the world. Wet conditions were observed throughout the year across southern South America, causing repeated heavy flooding in Argentina, Paraguay, and Uruguay. Wetter-than-usual conditions were also observed for eastern Europe and central Asia, alleviating the drought conditions of 2014 and 2015 in southern Russia. In the United States, California had its first wetter-than-average year since 2012, after being plagued by drought for several years. Even so, the area covered by drought in 2016 at the global scale was among the largest in the post-1950 record. For each month, at least 12% of land surfaces experienced severe drought conditions or worse, the longest such stretch in the record. In northeastern Brazil, drought conditions were observed for the fifth consecutive year, making this the longest drought on record in the region. Dry conditions were also observed in western Bolivia and Peru; it was Bolivia's worst drought in the past 25 years. In May, with abnormally warm and dry conditions already prevailing over western Canada for about a year, the human-induced Fort McMurray wildfire burned nearly 590000 hectares and became the costliest disaster in Canadian history, with $3 billion (U.S. dollars) in insured losses.

99 citations


Journal ArticleDOI
Morad Aaboud, Georges Aad1, Brad Abbott2, Ovsat Abdinov3  +2947 moreInstitutions (222)
TL;DR: In this article, a search for the decay of the Standard Model Higgs boson into a b (b) over bar pair when produced in association with a W or Z boson is performed with the ATLAS detector.
Abstract: A search for the decay of the Standard Model Higgs boson into a b (b) over bar pair when produced in association with a W or Z boson is performed with the ATLAS detector. The analysed data, corresp ...

Journal ArticleDOI
Morad Aaboud, Georges Aad1, Brad Abbott2, Jalal Abdallah3  +2854 moreInstitutions (191)
TL;DR: In this article, a sample of proton-proton collisions at 8$ TeV, corresponding to an integrated luminosity of 11.4 fb$^{-1}$ collected in 2012 with the ATLAS detector at the LHC.
Abstract: The production of two prompt $J/\psi$ mesons, each with transverse momenta $p_{\mathrm{T}}>8.5$ GeV and rapidity $|y| < 2.1$, is studied using a sample of proton-proton collisions at $\sqrt{s} = 8$ TeV, corresponding to an integrated luminosity of 11.4 fb$^{-1}$ collected in 2012 with the ATLAS detector at the LHC. The differential cross-section, assuming unpolarised $J/\psi$ production, is measured as a function of the transverse momentum of the lower-$p_{\mathrm{T}}$ $J/\psi$ meson, di-$J/\psi$ $p_{\mathrm{T}}$ and mass, the difference in rapidity between the two $J/\psi$ mesons, and the azimuthal angle between the two $J/\psi$ mesons. The fraction of prompt pair events due to double parton scattering is determined by studying kinematic correlations between the two $J/\psi$ mesons. The total and double parton scattering cross-sections are compared with predictions. The effective cross-section of double parton scattering is measured to be $\sigma_{\mathrm{eff}} = 6.3 \pm 1.6 \mathrm{(stat)} \pm 1.0 \mathrm{(syst)} \pm 0.1 \mathrm{(BF)} \pm 0.1 \mathrm{(lumi)}$ mb.

Journal ArticleDOI
TL;DR: Adding high-resolution radar observations from Sentinel-1 to the SMAP assimilation can increase the spatio-temporal accuracy of soil moisture estimates, demonstrating the complementary value of radar and radiometer observations.
Abstract: SMAP (Soil Moisture Active and Passive) radiometer observations at ∼40km resolution are routinely assimilated into the NASA Catchment Land Surface Model to generate the 9-km SMAP Level-4 Soil Moisture product. This study demonstrates that adding high-resolution radar observations from Sentinel-1 to the SMAP assimilation can increase the spatio-temporal accuracy of soil moisture estimates. Radar observations were assimilated either separately from or simultaneously with radiometer observations. Assimilation impact was assessed by comparing 3-hourly, 9-km surface and root-zone soil moisture simulations with in situ measurements from 9-km SMAP core validation sites and sparse networks, from May 2015 to December 2016. The Sentinel-1 assimilation consistently improved surface soil moisture, whereas root-zone impacts were mostly neutral. Relatively larger improvements were obtained from SMAP assimilation. The joint assimilation of SMAP and Sentinel-1 observations performed best, demonstrating the complementary value of radar and radiometer observations.

Journal ArticleDOI
TL;DR: It is argued that CDRs derived from satellite-based Earth observation (EO) should include rigorous uncertainty information to support the application of the data in contexts such as policy, climate modelling, and numerical weather prediction reanalysis.
Abstract: . The question of how to derive and present uncertainty information in climate data records (CDRs) has received sustained attention within the European Space Agency Climate Change Initiative (CCI), a programme to generate CDRs addressing a range of essential climate variables (ECVs) from satellite data. Here, we review the nature, mathematics, practicalities, and communication of uncertainty information in CDRs from Earth observations. This review paper argues that CDRs derived from satellite-based Earth observation (EO) should include rigorous uncertainty information to support the application of the data in contexts such as policy, climate modelling, and numerical weather prediction reanalysis. Uncertainty, error, and quality are distinct concepts, and the case is made that CDR products should follow international metrological norms for presenting quantified uncertainty. As a baseline for good practice, total standard uncertainty should be quantified per datum in a CDR, meaning that uncertainty estimates should clearly discriminate more and less certain data. In this case, flags for data quality should not duplicate uncertainty information, but instead describe complementary information (such as the confidence in the uncertainty estimate provided or indicators of conditions violating the retrieval assumptions). The paper discusses the many sources of error in CDRs, noting that different errors may be correlated across a wide range of timescales and space scales. Error effects that contribute negligibly to the total uncertainty in a single-satellite measurement can be the dominant sources of uncertainty in a CDR on the large space scales and long timescales that are highly relevant for some climate applications. For this reason, identifying and characterizing the relevant sources of uncertainty for CDRs is particularly challenging. The characterization of uncertainty caused by a given error effect involves assessing the magnitude of the effect, the shape of the error distribution, and the propagation of the uncertainty to the geophysical variable in the CDR accounting for its error correlation properties. Uncertainty estimates can and should be validated as part of CDR validation when possible. These principles are quite general, but the approach to providing uncertainty information appropriate to different ECVs is varied, as confirmed by a brief review across different ECVs in the CCI. User requirements for uncertainty information can conflict with each other, and a variety of solutions and compromises are possible. The concept of an ensemble CDR as a simple means of communicating rigorous uncertainty information to users is discussed. Our review concludes by providing eight concrete recommendations for good practice in providing and communicating uncertainty in EO-based climate data records.

Journal ArticleDOI
TL;DR: In this paper, the authors presented a new rainfall data set (SM2RAIN-CCI) obtained from the inversion of the satellite soil moisture (SM) observations derived from the ESA Climate Change Initiative (CCI), via SM 2RAIN (Brocca et al., 2014).
Abstract: . Accurate and long-term rainfall estimates are the main inputs for several applications, from crop modeling to climate analysis. In this study, we present a new rainfall data set (SM2RAIN-CCI) obtained from the inversion of the satellite soil moisture (SM) observations derived from the ESA Climate Change Initiative (CCI) via SM2RAIN (Brocca et al., 2014). Daily rainfall estimates are generated for an 18-year long period (1998–2015), with a spatial sampling of 0.25° on a global scale, and are based on the integration of the ACTIVE and the PASSIVE ESA CCI SM data sets. The quality of the SM2RAIN-CCI rainfall data set is evaluated by comparing it with two state-of-the-art rainfall satellite products, i.e. the Tropical Measurement Mission Multi-satellite Precipitation Analysis 3B42 real-time product (TMPA 3B42RT) and the Climate Prediction Center Morphing Technique (CMORPH), and one modeled data set (ERA-Interim). A quality check is carried out on a global scale at 1° of spatial sampling and 5 days of temporal sampling by comparing these products with the gauge-based Global Precipitation Climatology Centre Full Data Daily (GPCC-FDD) product. SM2RAIN-CCI shows relatively good results in terms of correlation coefficient (median value > 0.56), root mean square difference (RMSD, median value The SM2RAIN-CCI rainfall data set is freely available at https://doi.org/10.5281/zenodo.846259 .

Journal ArticleDOI
21 Feb 2017
TL;DR: It is demonstrated that the cellular composition in buccal swab samples can be determined by DNAm at two cell type-specific CpGs to improve epigenetic age predictions.
Abstract: Aging is reflected by highly reproducible DNA methylation (DNAm) changes that open new perspectives for estimation of chronological age in legal medicine. DNA can be harvested non-invasively from cells at the inside of a person's cheek using buccal swabs - but these specimens resemble heterogeneous mixtures of buccal epithelial cells and leukocytes with different epigenetic makeup. In this study, we have trained an age predictor based on three age-associated CpG sites (associated with the genesPDE4C, ASPA, and ITGA2B) for swab samples to reach a mean absolute deviation (MAD) between predicted and chronological age of 4.3 years in a training set and of 7.03 years in a validation set. Subsequently, the composition of buccal epithelial cells versus leukocytes was estimated by two additional CpGs (associated with the genes CD6 and SERPINB5). Results of this "Buccal-Cell-Signature" correlated with cell counts in cytological stains (R2 = 0.94). Combination of cell type-specific and age-associated CpGs into one multivariate model enabled age predictions with MADs of 5.09 years and 5.12 years in two independent validation sets. Our results demonstrate that the cellular composition in buccal swab samples can be determined by DNAm at two cell type-specific CpGs to improve epigenetic age predictions.

Journal ArticleDOI
TL;DR: In this article, the authors highlight the role of party-political contestation structuring parliamentary debates and votes in this increasingly politicised issue area, indicating that even though parliaments have arguably become more involved in foreign and security policy over time, any notions of parliamentarisation need to be treated with caution.
Abstract: It is customary to argue that foreign policy is very much dominated by the executive, with parliaments wielding limited influence. However, with the exception of the US Congress, legislative‒executive relations in the realm of foreign and security policy have attracted remarkably little scholarly attention. Drawing on a principal‒agent framework, this collection scrutinises the conventional wisdom of ‘executive autonomy’ in foreign affairs, indicating that even though parliaments have arguably become more involved in foreign and security policy over time, any notions of parliamentarisation need to be treated with caution. While expectations of consensus in the name of the national interest continue to play an important role in foreign policy decision-making, the papers highlight the role of party-political contestation structuring parliamentary debates and votes in this increasingly politicised issue area. This introductory paper introduces the analytical framework and hypotheses guiding the contr...

Journal ArticleDOI
Morad Aaboud, Alexander Kupco1, Peter Davison2, Samuel Webb3  +2938 moreInstitutions (222)
TL;DR: The results of a search for vector-like top quarks using events with exactly one lepton, at least four jets, and large missing transverse momentum are reported in this paper.
Abstract: The results of a search for vector-like top quarks using events with exactly one lepton, at least four jets, and large missing transverse momentum are reported The search is optimised for pair pro

Journal ArticleDOI
Morad Aaboud, Alexander Kupco1, Peter Davison2, Samuel Webb3  +2914 moreInstitutions (218)
TL;DR: In this paper, a measurement of the t-channel single-top-quark and single top-antiquark production cross-sections in the lepton+jets channel is presented, using 3.2 fb−1 of proton-proton collision data.
Abstract: A measurement of the t-channel single-top-quark and single-top-antiquark production cross-sections in the lepton+jets channel is presented, using 3.2 fb−1 of proton-proton collision data at a centr ...

Journal ArticleDOI
TL;DR: Global DNAm profiles of human mesenchymal stem cells (MSCs) and human umbilical vein endothelial cells (HUVECs) are analyzed to demonstrate that senescence‐associated DNAm changes are overall similar in these different cell types.
Abstract: Summary Replicative senescence has a major impact on function and integrity of cell preparations This process is reflected by continuous DNA methylation (DNAm) changes at specific CpG dinucleotides in the course of in vitro culture, and such modifications can be used to estimate the state of cellular senescence for quality control of cell preparations Still, it is unclear how senescence-associated DNAm changes are regulated and whether they occur simultaneously across a cell population In this study, we analyzed global DNAm profiles of human mesenchymal stem cells (MSCs) and human umbilical vein endothelial cells (HUVECs) to demonstrate that senescence-associated DNAm changes are overall similar in these different cell types Subsequently, an Epigenetic-Senescence-Signature, based on six CpGs, was either analyzed by pyrosequencing or by bar-coded bisulfite amplicon sequencing There was a good correlation between predicted and real passage numbers in bulk populations of MSCs (R2 = 067) and HUVECs (R2 = 097) However, when we analyzed the Epigenetic-Senescence-Signature in subclones of MSCs, the predictions revealed high variation and they were not related to the adipogenic or osteogenic differentiation potential of the subclones Notably, in clonally derived subpopulations, the DNAm levels of neighboring CpGs differed extensively, indicating that these genomic regions are not synchronously modified during senescence Taken together, senescence-associated DNAm changes occur in a highly reproducible manner, but they are not synchronously co-regulated They rather appear to be acquired stochastically—potentially evoked by other epigenetic modifications

Journal ArticleDOI
TL;DR: The authors examined the extent to which both the substance and the procedure of military interventions are contested among political parties and found that political parties on the left tend to favour strong parliamentary control whereas those on the right tend to prefer an unconstrained executive.
Abstract: The move from territorial defence to ‘wars of choice’ has influenced the domestic politics of military interventions. This paper examines the extent to which both the substance and the procedure of military interventions are contested among political parties. Regarding the substance, our analysis of Chapel Hill Expert Survey data demonstrates that across European states political parties on the right are more supportive of military missions than those on the left. On the decision-making procedures, our case studies of Germany, France, Spain and the United Kingdom show that political parties on the left tend to favour strong parliamentary control whereas those on the right tend to prefer an unconstrained executive, although with differences across countries. These findings challenge the view that ‘politics stops at the water’s edge’ and contribute to a better understanding of how political parties and parliaments influence military interventions.

01 Dec 2017
TL;DR: In this article, the authors demonstrate that adding high-resolution radar observations from Sentinel-1 to the SMAP assimilation can increase the spatio-temporal accuracy of soil moisture estimates.
Abstract: SMAP (Soil Moisture Active and Passive) radiometer observations at ∼40km resolution are routinely assimilated into the NASA Catchment Land Surface Model to generate the 9-km SMAP Level-4 Soil Moisture product This study demonstrates that adding high-resolution radar observations from Sentinel-1 to the SMAP assimilation can increase the spatio-temporal accuracy of soil moisture estimates Radar observations were assimilated either separately from or simultaneously with radiometer observations Assimilation impact was assessed by comparing 3-hourly, 9-km surface and root-zone soil moisture simulations with in situ measurements from 9-km SMAP core validation sites and sparse networks, from May 2015 to December 2016 The Sentinel-1 assimilation consistently improved surface soil moisture, whereas root-zone impacts were mostly neutral Relatively larger improvements were obtained from SMAP assimilation The joint assimilation of SMAP and Sentinel-1 observations performed best, demonstrating the complementary value of radar and radiometer observations

Journal ArticleDOI
TL;DR: This work isolated and expanded human bone marrow-derived MSCs in parallel with HPL and demonstrated that HPL significantly increases proliferation and leads to dramatic differences in cellular morphology, while global DNA-methylation profiles did not reveal any significant differences.
Abstract: Culture medium of mesenchymal stromal cells (MSCs) is usually supplemented with either human platelet lysate (HPL) or fetal calf serum (FCS). Many studies have demonstrated that proliferation and cellular morphology are affected by these supplements – it is therefore important to determine if they favor outgrowth of different subpopulations and thereby impact on the heterogeneous composition of MSCs. We have isolated and expanded human bone marrow-derived MSCs in parallel with HPL or FCS and demonstrated that HPL significantly increases proliferation and leads to dramatic differences in cellular morphology. Remarkably, global DNA-methylation profiles did not reveal any significant differences. Even at the transcriptomic level, there were only moderate changes in pairwise comparison. Furthermore, the effects on proliferation, cytoskeletal organization, and focal adhesions were reversible by interchanging to opposite culture conditions. These results indicate that cultivation of MSCs with HPL or FCS has no systematic bias for specific cell types.

Journal ArticleDOI
Morad Aaboud, Alexander Kupco1, Peter Davison2, Samuel Webb3  +2937 moreInstitutions (222)
TL;DR: In this article, a search for the pair production of heavy vector-like T quarks was presented, targeting the T quark decays to a W boson and a b-quark.
Abstract: A search is presented for the pair production of heavy vector-like T quarks, primarily targeting the T quark decays to a W boson and a b-quark. The search is based on 36: 1 fb(-1) of pp collisions ...

Journal ArticleDOI
Morad Aaboud, Georges Aad1, Brad Abbott2, Jalal Abdallah3  +2853 moreInstitutions (197)
TL;DR: In this article, the production cross section of a Z boson in association with jets in proton-proton collisions at root s = 13TeV was measured using data corresponding to an integrated luminosity.
Abstract: Measurements of the production cross section of a Z boson in association with jets in proton-proton collisions at root s = 13TeV are presented, using data corresponding to an integrated luminosity

Journal ArticleDOI
Morad Aaboud, Georges Aad1, Brad Abbott2, Ovsat Abdinov3  +2932 moreInstitutions (223)
TL;DR: In this article, the authors present searches for the Zγ decay of the Higgs boson and for narrow high-mass resonances decaying to Zγ, exploiting Z boson decays to pairs of electrons or muons.
Abstract: This article presents searches for the Zγ decay of the Higgs boson and for narrow high-mass resonances decaying to Zγ, exploiting Z boson decays to pairs of electrons or muons. The data analysis uses 36.1 fb−1 of pp collisions at √s=13 recorded by the ATLAS detector at the CERN Large Hadron Collider. The data are found to be consistent with the expected Standard Model background. The observed (expected — assuming Standard Model pp → H → Zγ production and decay) upper limit on the production cross section times the branching ratio for pp → H → Zγ is 6.6. (5.2) times the Standard Model prediction at the 95% confidence level for a Higgs boson mass of 125.09 GeV. In addition, upper limits are set on the production cross section times the branching ratio as a function of the mass of a narrow resonance between 250 GeV and 2.4 TeV, assuming spin-0 resonances produced via gluon-gluon fusion, and spin-2 resonances produced via gluon-gluon or quark-antiquark initial states. For high-mass spin-0 resonances, the observed (expected) limits vary between 88 fb (61 fb) and 2.8 fb (2.7 fb) for the mass range from 250 GeV to 2.4 TeV at the 95% confidence level.

Journal ArticleDOI
01 Jun 2017-Water
TL;DR: In this paper, the applicability of an existing phenology-based classification method for continental-scale rice cropland mapping using S-1 backscatter time series was evaluated using eight selected European test sites situated in six Mediterranean countries.
Abstract: Rice farming is one of the most important activities in the agriculture sector, producing staple food for the majority of the world's growing population Accurate and up-to-date assessment of the spatial distribution of rice cultivated area is a key information requirement of all stakeholders including policy makers, rice farmers and consumers Timely assessment with high precision is, eg, crucial for water resource management, market prices control and during humanitarian food crisis Recently, two Sentinel-1 (S-1) satellites carrying a C-band Synthetic Aperture Radar (SAR) sensor were launched by the European Space Agency (ESA) within the homework of the Copernicus program The advanced data acquisition capabilities of S-1 provide a unique opportunity to monitor different land cover types at high spatial (20 m) and temporal (twice-weekly to biweekly) resolution The objective of this research is to evaluate the applicability of an existing phenology-based classification method for continental-scale rice cropland mapping using S-1 backscatter time series In this study, the S-1 images were collected during the rice growing season of 2015 covering eight selected European test sites situated in six Mediterranean countries Due to the better rice classification capabilities of SAR cross-polarized measurement as compared to co-polarized data, S-1 cross-polarized (VH) data were used Phenological parameters derived from the S-1 VH backscatter time series were used as an input to a knowledge-based decision-rule classifier in order to classify the input data into rice and non-rice areas The classification results were evaluated using multiple regions of interest (ROIs) drawn from high-resolution optical remote sensing (SPOT 5) data and the European CORINE land cover (CLC 2012) product An overall accuracy of more than 70% for all eight study sites was achieved The S-1 based classification maps reveal much more details compared to the rice field class contained in the CLC 2012 product These findings demonstrate the potential and feasibility of using S-1 VH data to develop an operational rice crop monitoring framework at the continental scale

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TL;DR: In this article, a search for heavy resonances decaying to a W or Z boson and a Higgs boson in the qq¯(′)bb¯ final state is described.

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Morad Aaboud, Georges Aad1, Brad Abbott2, Jalal Abdallah3  +2845 moreInstitutions (192)
TL;DR: In this article, the authors presented a search for new resonances with mass larger than 250 GeV, decaying to a Z boson and a photon, and the data were found to be consistent with the expected background in the whole mass range investigated and upper limits were set on the production cross section times decay branching ratio to Z\gamma.

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Morad Aaboud, Alexander Kupco1, Peter Davison2, Samuel Webb3  +2954 moreInstitutions (222)
TL;DR: In this paper, the triple-differential cross section for the Drell-Yan process was measured for invariant masses of the lepton pairs, m$_{ll}$, between 46 and 200 GeV using a sample of 20.2 fb$−1}$ of pp collisions data at a centre-of-mass energy of $ \sqrt{s}=8 $ TeV collected by the ATLAS detector at the LHC in 2012.
Abstract: This paper presents a measurement of the triple-differential cross section for the Drell-Yan process Z/γ$^{*}$ → l$^{+}$ l$^{−}$ where l is an electron or a muon. The measurement is performed for invariant masses of the lepton pairs, m$_{ll}$ , between 46 and 200 GeV using a sample of 20.2 fb$^{−1}$ of pp collisions data at a centre-of-mass energy of $ \sqrt{s}=8 $ TeV collected by the ATLAS detector at the LHC in 2012. The data are presented in bins of invariant mass, absolute dilepton rapidity, |y$_{ll}$|, and the angular variable cos θ$^{*}$ between the outgoing lepton and the incoming quark in the Collins-Soper frame. The measurements are performed in the range |y$_{ll}$ | < 2.4 in the muon channel, and extended to |y$_{ll}$ | < 3.6 in the electron channel. The cross sections are used to determine the Z boson forward-backward asymmetry as a function of |y$_{ll}$ | and m$_{ll}$ . The measurements achieve high-precision, below the percent level in the pole region, excluding the uncertainty in the integrated luminosity, and are in agreement with predictions. These precision data are sensitive to the parton distribution functions and the effective weak mixing angle.