Wolfgang Wagner

Bio: Wolfgang Wagner is an academic researcher from Vienna University of Technology. The author has contributed to research in topics: Large Hadron Collider & Top quark. The author has an hindex of 156, co-authored 2342 publications receiving 123391 citations. Previous affiliations of Wolfgang Wagner include University of Pennsylvania & University of Amsterdam.

The PSI ultra-cold neutron source

Abstract: A new type of ultra-cold neutron (UCN) source based on the spallation process is under construction at PSI. The essential elements are a pulsed proton beam with highest intensity ( I p ≥ 2 mA ) and a low duty cycle (1%), a lead spallation target, a large D 2 O moderator and a solid deuterium ( sD 2 ) converter system. Spallation neutrons are thermalized in the D 2 O , further cooled and partially downscattered into the ultra-cold neutron range in the sD 2 . The expected UCN density is higher than 1000 UCN / cm 3 in typical experiments, an increase of almost two orders of magnitude over the best source currently available (at ILL). The new UCN source is expected to come into operation in 2009.

Prompt and non-prompt J/ψ and ψ (2S) suppression at high transverse momentum in 5.02 TeV Pb+Pb collisions with the ATLAS experiment

Abstract: A measurement of J/ψ and ψ(2S) production is presented. It is based on a data sample from Pb+Pb collisions at sNN−−−√=5.02 TeV and pp collisions at s√=5.02 TeV recorded by the ATLAS detector at the LHC in 2015, corresponding to an integrated luminosity of 0.42 nb−1 and 25 pb−1 in Pb+Pb and pp, respectively. The measurements of per-event yields, nuclear modification factors, and non-prompt fractions are performed in the dimuon decay channel for 9

First run II measurement of the W boson mass at the Fermilab Tevatron

Abstract: We describe a measurement of the W boson mass m{sub W} using 200 pb{sup -1} of {radical}s = 1.96 TeV p{bar p} collision data taken with the CDF II detector. With a sample of 63,964 W {yields} e{nu} candidates and 51,128 W {yields} {mu}{nu} candidates, we measure m{sub W} = [80.413 {+-} 0.034(stat.) {+-} 0.034 (sys.) = 80.413 {+-} 0.048] GeV/c{sup 2}. This is the single most precise m{sub W} measurement to date. When combined with other measured electroweak parameters, this result further constrains the properties of new unobserved particles coupling to W and Z bosons.

The binding of DYNLL2 to myosin Va requires alternatively spliced exon B and stabilizes a portion of the myosin's coiled-coil domain.

Abstract: The myosin Va light chain DYNLL2 has been proposed to function as an adaptor to link the myosin to certain cargo. Here, we mapped the binding site for DYNLL2 within the myosin Va heavy chain. Copurification and pull-down experiments showed that the heavy chain contains a single DYNLL2 binding site and that this site resides within a discontinuity in the myosin's central coiled-coil domain. Importantly, exon B, an alternatively spliced, three-amino acid exon, is a part of this binding site, and we show in the context of full-length myosin Va that this exon is required for DYNLL2-myosin Va interaction. We investigated the effect of DYNLL2 binding on the structure of a myosin Va heavy chain fragment that contains the DYNLL2 binding site and flanking sequence, only parts of which are strongly predicted to form a coiled coil. Circular dichroism measurements revealed a DYNLL2-induced change in the secondary structure of this dimeric myosin fragment that is consistent with an increase in alpha-helical coiled-coil content. Moreover, the binding of DYNLL2 considerably stabilizes this heavy chain fragment against thermal denaturation. Analytical ultracentrifugation yielded an apparent association constant of approximately 3 x 10(6) M(-1) for the interaction of DYNLL2 with the dimeric myosin fragment. Together, these data show that alternative splicing of the myosin Va heavy chain controls DYNLL2-myosin Va interaction and that DYNLL2 binding alters the structure of a portion of the myosin's coiled-coil domain. These results suggest that exon B could have a significant impact on the conformation and regulatory folding of native myosin Va, as well as on its interaction with certain cargos.

I and i

Abstract: There is, I think, something ethereal about i —the square root of minus one. I remember first hearing about it at school. It seemed an odd beast at that time—an intruder hovering on the edge of reality. Usually familiarity dulls this sense of the bizarre, but in the case of i it was the reverse: over the years the sense of its surreal nature intensified. It seemed that it was impossible to write mathematics that described the real world in …

Fast parallel algorithms for short-range molecular dynamics

Abstract: Three parallel algorithms for classical molecular dynamics are presented. The first assigns each processor a fixed subset of atoms; the second assigns each a fixed subset of inter-atomic forces to compute; the third assigns each a fixed spatial region. The algorithms are suitable for molecular dynamics models which can be difficult to parallelize efficiently—those with short-range forces where the neighbors of each atom change rapidly. They can be implemented on any distributed-memory parallel machine which allows for message-passing of data between independently executing processors. The algorithms are tested on a standard Lennard-Jones benchmark problem for system sizes ranging from 500 to 100,000,000 atoms on several parallel supercomputers--the nCUBE 2, Intel iPSC/860 and Paragon, and Cray T3D. Comparing the results to the fastest reported vectorized Cray Y-MP and C90 algorithm shows that the current generation of parallel machines is competitive with conventional vector supercomputers even for small problems. For large problems, the spatial algorithm achieves parallel efficiencies of 90% and a 1840-node Intel Paragon performs up to 165 faster than a single Cray C9O processor. Trade-offs between the three algorithms and guidelines for adapting them to more complex molecular dynamics simulations are also discussed.

疟原虫var基因转换速率变化导致抗原变异[英]／Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A

Abstract: 抗原变异可使得多种致病微生物易于逃避宿主免疫应答。表达在感染红细胞表面的恶性疟原虫红细胞表面蛋白1（PfPMP1）与感染红细胞、内皮细胞、树突状细胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作用。每个单倍体基因组var基因家族编码约60种成员，通过启动转录不同的var基因变异体为抗原变异提供了分子基础。