Wolfgang Wagner

Bio: Wolfgang Wagner is an academic researcher from Vienna University of Technology. The author has contributed to research in topics: Large Hadron Collider & Top quark. The author has an hindex of 156, co-authored 2342 publications receiving 123391 citations. Previous affiliations of Wolfgang Wagner include University of Pennsylvania & University of Amsterdam.

Epigenetic Aging Signatures Are Coherently Modified in Cancer.

Abstract: Aging is associated with highly reproducible DNA methylation (DNAm) changes, which may contribute to higher prevalence of malignant diseases in the elderly. In this study, we analyzed epigenetic aging signatures in 5,621 DNAm profiles of 25 cancer types from The Cancer Genome Atlas (TCGA). Overall, age-associated DNAm patterns hardly reflect chronological age of cancer patients, but they are coherently modified in a non-stochastic manner, particularly at CpGs that become hypermethylated upon aging in non-malignant tissues. This coordinated regulation in epigenetic aging signatures can therefore be used for aberrant epigenetic age-predictions, which facilitate disease stratification. For example, in acute myeloid leukemia (AML) higher epigenetic age-predictions are associated with increased incidence of mutations in RUNX1, WT1, and IDH2, whereas mutations in TET2, TP53, and PML-PARA translocation are more frequent in younger age-predictions. Furthermore, epigenetic aging signatures correlate with overall survival in several types of cancer (such as lower grade glioma, glioblastoma multiforme, esophageal carcinoma, chromophobe renal cell carcinoma, cutaneous melanoma, lung squamous cell carcinoma, and neuroendocrine neoplasms). In conclusion, age-associated DNAm patterns in cancer are not related to chronological age of the patient, but they are coordinately regulated, particularly at CpGs that become hypermethylated in normal aging. Furthermore, the apparent epigenetic age-predictions correlate with clinical parameters and overall survival in several types of cancer, indicating that regulation of DNAm patterns in age-associated CpGs is relevant for cancer development.

Search for chargino-neutralino production using recursive jigsaw reconstruction in final states with two or three charged leptons in proton-proton collisions at √s=13 TeV with the ATLAS detector

Abstract: A search for electroweak production of supersymmetric particles is performed in two-lepton and three-lepton final states using recursive jigsaw reconstruction, a technique that assigns reconstructed objects to the most probable hemispheres of the decay trees, allowing one to construct tailored kinematic variables to separate the signal and background. The search uses data collected in 2015 and 2016 by the ATLAS experiment in s=13 TeV proton-proton collisions at the CERN Large Hadron Collider corresponding to an integrated luminosity of 36.1 fb-1. Chargino-neutralino pair production, with decays via W/Z bosons, is studied in final states involving leptons and jets and missing transverse momentum for scenarios with large and intermediate mass splittings between the parent particle and lightest supersymmetric particle, as well as for the scenario where this mass splitting is close to the mass of the Z boson. The latter case is challenging since the vector bosons are produced with kinematic properties that are similar to those in Standard Model processes. Results are found to be compatible with the Standard Model expectations in the signal regions targeting large and intermediate mass splittings, and chargino-neutralino masses up to 600 GeV are excluded at 95% confidence level for a massless lightest supersymmetric particle. Excesses of data above the expected background are found in the signal regions targeting low mass splittings, and the largest local excess amounts to 3.0 standard deviations. © 2018 CERN, for the ATLAS Collaboration. Published by the American Physical Society.

The Democratic Control of Military Power Europe

Abstract: The development of a ESDP has raised concerns over the EU's identity as a ‘civilian power’. Whereas concerns over a gradual replacement of civilian policy instruments by military force have been most prevalent, this article focuses on a neglected dimension of the civilian power-concept, namely on the repercussions of the ESDP for the democratic control of security and defence policy. It argues that the Europeanization of defence politics leads to a democratic deficit because national parliaments' capacity to control executive decisions to use military force has been weakened by the ESDP and neither the European Parliament nor the former WEU assembly has been able to compensate for this loss of parliamentary control. This democratic deficit may not only damage the legitimacy of EU-led military missions but may also compromise the EU's ability to lead by virtuous example.

I and i

Abstract: There is, I think, something ethereal about i —the square root of minus one. I remember first hearing about it at school. It seemed an odd beast at that time—an intruder hovering on the edge of reality. Usually familiarity dulls this sense of the bizarre, but in the case of i it was the reverse: over the years the sense of its surreal nature intensified. It seemed that it was impossible to write mathematics that described the real world in …

Fast parallel algorithms for short-range molecular dynamics

Abstract: Three parallel algorithms for classical molecular dynamics are presented. The first assigns each processor a fixed subset of atoms; the second assigns each a fixed subset of inter-atomic forces to compute; the third assigns each a fixed spatial region. The algorithms are suitable for molecular dynamics models which can be difficult to parallelize efficiently—those with short-range forces where the neighbors of each atom change rapidly. They can be implemented on any distributed-memory parallel machine which allows for message-passing of data between independently executing processors. The algorithms are tested on a standard Lennard-Jones benchmark problem for system sizes ranging from 500 to 100,000,000 atoms on several parallel supercomputers--the nCUBE 2, Intel iPSC/860 and Paragon, and Cray T3D. Comparing the results to the fastest reported vectorized Cray Y-MP and C90 algorithm shows that the current generation of parallel machines is competitive with conventional vector supercomputers even for small problems. For large problems, the spatial algorithm achieves parallel efficiencies of 90% and a 1840-node Intel Paragon performs up to 165 faster than a single Cray C9O processor. Trade-offs between the three algorithms and guidelines for adapting them to more complex molecular dynamics simulations are also discussed.

疟原虫var基因转换速率变化导致抗原变异[英]／Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A

Abstract: 抗原变异可使得多种致病微生物易于逃避宿主免疫应答。表达在感染红细胞表面的恶性疟原虫红细胞表面蛋白1（PfPMP1）与感染红细胞、内皮细胞、树突状细胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作用。每个单倍体基因组var基因家族编码约60种成员，通过启动转录不同的var基因变异体为抗原变异提供了分子基础。