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Wolfgang Wagner

Bio: Wolfgang Wagner is an academic researcher from Vienna University of Technology. The author has contributed to research in topics: Large Hadron Collider & Top quark. The author has an hindex of 156, co-authored 2342 publications receiving 123391 citations. Previous affiliations of Wolfgang Wagner include University of Pennsylvania & University of Amsterdam.


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TL;DR: A maternally expressed, imprinted lncRNA, H19, that increases BAT oxidative metabolism and energy expenditure is identified and it is demonstrated that H19 recruits PEG-inactivating H19-MBD1 complexes and acts as BAT-selective PEG gatekeeper.
Abstract: Increasing brown adipose tissue (BAT) thermogenesis in mice and humans improves metabolic health and understanding BAT function is of interest for novel approaches to counteract obesity. The role of long noncoding RNAs (lncRNAs) in these processes remains elusive. We observed maternally expressed, imprinted lncRNA H19 increased upon cold-activation and decreased in obesity in BAT. Inverse correlations of H19 with BMI were also observed in humans. H19 overexpression promoted, while silencing of H19 impaired adipogenesis, oxidative metabolism and mitochondrial respiration in brown but not white adipocytes. In vivo, H19 overexpression protected against DIO, improved insulin sensitivity and mitochondrial biogenesis, whereas fat H19 loss sensitized towards HFD weight gains. Strikingly, paternally expressed genes (PEG) were largely absent from BAT and we demonstrated that H19 recruits PEG-inactivating H19-MBD1 complexes and acts as BAT-selective PEG gatekeeper. This has implications for our understanding how monoallelic gene expression affects metabolism in rodents and, potentially, humans.

94 citations

Journal ArticleDOI
T. Aaltonen1, Jahred Adelman2, T. Akimoto3, M. G. Albrow4  +655 moreInstitutions (75)
TL;DR: In this paper, the authors measured the time dependence of the ratio of decay rates for the rare decay D0->K+pi- to the Cabibbo-favored decay D 0->K-pi+.
Abstract: We measure the time dependence of the ratio of decay rates for the rare decay D0->K+pi- to the Cabibbo-favored decay D0->K-pi+. We use a signal of 12.7 x10^3 D0->K+pi decays with proper decay times between 0.75 and 10 mean D0 lifetimes. The data sample was recorded with the CDF II detector at the Fermilab Tevatron and corresponds to an integrated luminosity of 1.5 fb-1 of p-pbar collisions at sqrt(s) = 1.96 TeV. We search for D0-D0bar mixing and measure the mixing parameters to be Rd = (3.04 +/- 0.55) x10^{-3}, y' = (8.5 +/- 7.6) x10^{-3}, and x'^2 = (-0.12 +/- 0.35) x10^{-3}. We report Bayesian probability contours in the x'^2-y' plane and find that the data are inconsistent with the no-mixing hypothesis with a probability equivalent to 3.8 Gaussian standard deviations.

94 citations

Journal ArticleDOI
TL;DR: Stereoscopically enhanced 3D lectures are valid methods of imparting neuroanatomical knowledge and are well received by students and more research is required to define and develop the role of large-group VR systems in modern neuroan atomy curricula.
Abstract: Introduction Three-dimensional (3D) computer graphics are increasingly used to supplement the teaching of anatomy. While most systems consist of a program which produces 3D renderings on a workstation with a standard screen, the Dextrobeam virtual reality VR environment allows the presentation of spatial neuroanatomical models to larger groups of students through a stereoscopic projection system. Materials and methods Second-year medical students ( n = 169) were randomly allocated to receive a standardised pre-recorded audio lecture detailing the anatomy of the third ventricle accompanied by either a two-dimensional (2D) PowerPoint presentation ( n = 80) or a 3D animated tour of the third ventricle with the DextroBeam. Students completed a 10-question multiple-choice exam based on the content learned and a subjective evaluation of the teaching method immediately after the lecture. Results Students in the 2D group achieved a mean score of 5.19 (±2.12) compared to 5.45 (±2.16) in the 3D group, with the results in the 3D group statistically non-inferior to those of the 2D group ( p p Conclusion Stereoscopically enhanced 3D lectures are valid methods of imparting neuroanatomical knowledge and are well received by students. More research is required to define and develop the role of large-group VR systems in modern neuroanatomy curricula.

94 citations

Journal ArticleDOI
Georges Aad1, Brad Abbott2, Jalal Abdallah3, S. Abdel Khalek  +2948 moreInstitutions (211)
TL;DR: In this article, fiducial and differential cross-sections of Higgs boson production in the H -> ZZ* -> 4l decay channel are presented, based on 20.3 fb(-1) of pp collision data, produced at root s= 8 TeV centre-of-mass energy at the LHC and recorded by the ATLAS detector.

93 citations

Journal ArticleDOI
Georges Aad1, Alexander Kupco2, Bjørn Hallvard Samset3, P. Laurelli4  +2895 moreInstitutions (182)
TL;DR: In this article, the production cross sections of Upsilon(1S,2S,3S) mesons are reconstructed using the dimuon decay mode. And the results of the reconstruction are compared to several theoretical models of upsilon meson production, finding that none provide an accurate description of the data over the full range of Upsilicon transverse momenta accessible with this data set.
Abstract: Using 1.8 fb(-1) of pp collisions at a center- of- mass energy of 7 TeV recorded by the ATLAS detector at the Large Hadron Collider, we present measurements of the production cross sections of Upsilon(1S,2S,3S) mesons. Upsilon mesons are reconstructed using the dimuon decay mode. Total production cross sections for p(T) < 70 GeV and in the rapidity interval vertical bar y(Upsilon)vertical bar < 2. 25 are measured to be, 8.01 +/- 0.02 +/- 0.36 +/- 0.31 nb, 2.05 +/- 0.01 +/- 0.12 +/- 0.08 nb, and 0.92 +/- 0.01 +/- 0.07 +/- 0.04 nb, respectively, with uncertainties separated into statistical, systematic, and luminosity measurement effects. In addition, differential cross section times dimuon branching fractions for Upsilon(1S), Upsilon(2S), and Upsilon(3S) as a function of Upsilon transverse momentum pT and rapidity are presented. These cross sections are obtained assuming unpolarized production. If the production polarization is fully transverse or longitudinal with no azimuthal dependence in the helicity frame, the cross section may vary by approximately +/- 20%. If a nontrivial azimuthal dependence is considered, integrated cross sections may be significantly enhanced by a factor of 2 or more. We compare our results to several theoretical models of Upsilon meson production, finding that none provide an accurate description of our data over the full range of Upsilon transverse momenta accessible with this data set.

93 citations


Cited by
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[...]

08 Dec 2001-BMJ
TL;DR: There is, I think, something ethereal about i —the square root of minus one, which seems an odd beast at that time—an intruder hovering on the edge of reality.
Abstract: There is, I think, something ethereal about i —the square root of minus one. I remember first hearing about it at school. It seemed an odd beast at that time—an intruder hovering on the edge of reality. Usually familiarity dulls this sense of the bizarre, but in the case of i it was the reverse: over the years the sense of its surreal nature intensified. It seemed that it was impossible to write mathematics that described the real world in …

33,785 citations

01 May 1993
TL;DR: Comparing the results to the fastest reported vectorized Cray Y-MP and C90 algorithm shows that the current generation of parallel machines is competitive with conventional vector supercomputers even for small problems.
Abstract: Three parallel algorithms for classical molecular dynamics are presented. The first assigns each processor a fixed subset of atoms; the second assigns each a fixed subset of inter-atomic forces to compute; the third assigns each a fixed spatial region. The algorithms are suitable for molecular dynamics models which can be difficult to parallelize efficiently—those with short-range forces where the neighbors of each atom change rapidly. They can be implemented on any distributed-memory parallel machine which allows for message-passing of data between independently executing processors. The algorithms are tested on a standard Lennard-Jones benchmark problem for system sizes ranging from 500 to 100,000,000 atoms on several parallel supercomputers--the nCUBE 2, Intel iPSC/860 and Paragon, and Cray T3D. Comparing the results to the fastest reported vectorized Cray Y-MP and C90 algorithm shows that the current generation of parallel machines is competitive with conventional vector supercomputers even for small problems. For large problems, the spatial algorithm achieves parallel efficiencies of 90% and a 1840-node Intel Paragon performs up to 165 faster than a single Cray C9O processor. Trade-offs between the three algorithms and guidelines for adapting them to more complex molecular dynamics simulations are also discussed.

29,323 citations

28 Jul 2005
TL;DR: PfPMP1)与感染红细胞、树突状组胞以及胎盘的单个或多个受体作用,在黏附及免疫逃避中起关键的作�ly.
Abstract: 抗原变异可使得多种致病微生物易于逃避宿主免疫应答。表达在感染红细胞表面的恶性疟原虫红细胞表面蛋白1(PfPMP1)与感染红细胞、内皮细胞、树突状细胞以及胎盘的单个或多个受体作用,在黏附及免疫逃避中起关键的作用。每个单倍体基因组var基因家族编码约60种成员,通过启动转录不同的var基因变异体为抗原变异提供了分子基础。

18,940 citations

Journal ArticleDOI
TL;DR: In this paper, Imagined communities: Reflections on the origin and spread of nationalism are discussed. And the history of European ideas: Vol. 21, No. 5, pp. 721-722.

13,842 citations

Journal ArticleDOI
TL;DR: Reading a book as this basics of qualitative research grounded theory procedures and techniques and other references can enrich your life quality.

13,415 citations