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Wolfram Bode
Researcher at Max Planck Society
Publications - 258
Citations - 27599
Wolfram Bode is an academic researcher from Max Planck Society. The author has contributed to research in topics: Protein structure & Thrombin. The author has an hindex of 89, co-authored 258 publications receiving 26942 citations. Previous affiliations of Wolfram Bode include Heidelberg University.
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Journal ArticleDOI
The cystatins: protein inhibitors of cysteine proteinases.
Vito Turk,Wolfram Bode +1 more
TL;DR: Recently determined crystal structures of chicken cystatin and human stefin B established a new mechanism of interaction between cysteine proteinases and their inhibitors which is fundamentally different from the standard mechanism for serine proteinase inhibitors and their inhibitor.
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Astacins, serralysins, snake venom and matrix metalloproteinases exhibit identical zinc-binding environments (HEXXHXXGXXH and Met-turn) and topologies and should be grouped into a common family, the 'metzincins'
TL;DR: X‐ray crystal structures of two zinc endopeptidases, astacin from crayfish and adamalysin II from snake venom, reveal a strong overall topological equivalence and virtually identical extended HEXXHXXGXXH zinc‐binding segments, but in addition a methionine‐containing turn of similar conformation (the ‘Met‐turn’), which forms a hydrophobic basis for the zinc ion and the three liganding histidine residues.
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The structure of a complex of recombinant hirudin and human alpha-thrombin
Timothy J. Rydel,K. G. Ravichandran,Alexander Tulinsky,Wolfram Bode,Robert Huber,Carolyn Roitsch,John W. Fenton +6 more
TL;DR: The crystallographic structure of a recombinant hirudin-thrombin complex has been solved at 2.3 angstrom (A) resolution and abundant interactions may account for the high affinity and specificity of hirUDin.
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The metzincins--topological and sequential relations between the astacins, adamalysins, serralysins, and matrixins (collagenases) define a superfamily of zinc-peptidases.
Walter Stöcker,Frank Grams,Ulrich Baumann,Peter Reinemer,F. X. Gomis-Rüth,David B. McKay,Wolfram Bode +6 more
TL;DR: The corresponding four distinct families of zinc peptidases, the astacins, the matrix metalloproteinases (matrixins, collagenases), the adamalysins/reprolysins (snake venom proteinases/reproductive tract proteins), and the serralysins appear to have originated by divergent evolution from a common ancestor and form a superfamily of proteolytic enzymes for which the designation “metzincins” has been proposed.
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Structural basis of the activation and action of trypsin
Robert Huber,Wolfram Bode +1 more