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Wolfram Goessling
Researcher at Brigham and Women's Hospital
Publications - 158
Citations - 12533
Wolfram Goessling is an academic researcher from Brigham and Women's Hospital. The author has contributed to research in topics: Zebrafish & Stem cell. The author has an hindex of 43, co-authored 147 publications receiving 10696 citations. Previous affiliations of Wolfram Goessling include Boston Children's Hospital & Broad Institute.
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Journal ArticleDOI
Transparent Adult Zebrafish as a Tool for In Vivo Transplantation Analysis
Richard M. White,Anna Sessa,Christopher J. Burke,Teresa V. Bowman,Jocelyn LeBlanc,Craig J. Ceol,Caitlin Bourque,Michael Dovey,Michael Dovey,Wolfram Goessling,Wolfram Goessling,Caroline E. Burns,Leonard I. Zon,Leonard I. Zon +13 more
TL;DR: A transparent adult zebrafish is created in which either hematopoietic stem/progenitor cells or tumor cells are transplanted, serving as the ideal combination of both sensitivity and resolution for in vivo stem cell analyses.
Journal ArticleDOI
Prostaglandin E2 regulates vertebrate haematopoietic stem cell homeostasis
Trista E. North,Wolfram Goessling,Wolfram Goessling,Carl R. Walkley,Claudia Lengerke,Kamden R. Kopani,Kamden R. Kopani,Allegra M. Lord,Allegra M. Lord,Gerhard J. Weber,Gerhard J. Weber,Teresa V. Bowman,Teresa V. Bowman,Il Ho Jang,Tilo Grosser,Garret A. FitzGerald,George Q. Daley,Stuart H. Orkin,Stuart H. Orkin,Leonard I. Zon,Leonard I. Zon +20 more
TL;DR: The conserved role for PGE2 in the regulation of vertebrate HSC homeostasis indicates that modulation of the prostaglandin pathway may facilitate expansion of HSC number for therapeutic purposes.
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The Wnt/β-Catenin Pathway Is Required for the Development of Leukemia Stem Cells in AML
Yingzi Wang,Andrei V. Krivtsov,Amit U. Sinha,Trista E. North,Trista E. North,Wolfram Goessling,Wolfram Goessling,Zhaohui Feng,Leonard I. Zon,Leonard I. Zon,Scott A. Armstrong +10 more
TL;DR: It is shown that the Wnt/β-catenin signaling pathway is required for self-renewal of LSCs that are derived from either hematopoietic stem cells (HSC) or more differentiated granulocyte-macrophage progenitors (GMP).
Journal ArticleDOI
Genetic interaction of PGE2 and Wnt signaling regulates developmental specification of stem cells and regeneration.
Wolfram Goessling,Trista E. North,Trista E. North,Sabine Loewer,Sabine Loewer,Allegra M. Lord,Allegra M. Lord,Sang Lee,Sang Lee,Cristi L. Stoick-Cooper,Gilbert Weidinger,Mark Puder,Mark Puder,George Q. Daley,George Q. Daley,Randall T. Moon,Leonard I. Zon,Leonard I. Zon +17 more
TL;DR: It is shown that wnt reporter activity in zebrafish HSCs is responsive to PGE2 modulation, demonstrating a direct interaction in vivo and suggesting the P GE2/Wnt interaction is a master regulator of vertebrate regeneration and recovery.
Journal ArticleDOI
β-Catenin-Driven Cancers Require a YAP1 Transcriptional Complex for Survival and Tumorigenesis
Joseph Rosenbluh,Deepak Nijhawan,Deepak Nijhawan,Deepak Nijhawan,Andrew G. Cox,Andrew G. Cox,Xingnan Li,James T. Neal,Eric J. Schafer,Eric J. Schafer,Eric J. Schafer,Travis I. Zack,Travis I. Zack,Xiaoxing Wang,Xiaoxing Wang,Xiaoxing Wang,Aviad Tsherniak,Anna C. Schinzel,Anna C. Schinzel,Anna C. Schinzel,Diane D. Shao,Diane D. Shao,Diane D. Shao,Steven E. Schumacher,Steven E. Schumacher,Barbara A. Weir,Barbara A. Weir,Francisca Vazquez,Francisca Vazquez,Glenn S. Cowley,David E. Root,Jill P. Mesirov,Rameen Beroukhim,Rameen Beroukhim,Rameen Beroukhim,Calvin J. Kuo,Wolfram Goessling,William C. Hahn +37 more
TL;DR: It is found that β-catenin active cancers are dependent on a signaling pathway involving the transcriptional regulator YAP1 and the transcription factor TBX5, and this complex is essential to the transformation and survival of β- catenin-driven cancers.