Wu Fengmin

Bio: Wu Fengmin is an academic researcher from Zhejiang Sci-Tech University. The author has contributed to research in topics: Depth of field & Display device. The author has an hindex of 4, co-authored 15 publications receiving 47 citations.

Optical field display method and optical field display engine

Abstract: The invention relates to the field of display, in particular to an optical field display method and an optical field display engine. A projector is used for sequentially projecting two-dimensional image information sequences in a specified visual angle range according to a time sequence, the two-dimensional image information sequences are projected to a space of a corresponding visual angle rangethrough galvanometer reflection and scanning, the reflection angle of the galvanometer is in one-to-one correspondence to the view angle of the two-dimensional image, and when the galvanometer scans adesignated angle position, the projector is used for synchronously projecting the two-dimensional image information of the corresponding visual angle range; a controller is used for controlling the galvanometer to scan back and forth in a set angle as well as coordinating the time sequence of the projector and synchronously projecting the two-dimensional image information of the corresponding visual angle range according to the angle scanned by the galvanometer, so that a three-dimensional image is formed in the space. According to the optical field display method in the invention, three-dimensional images with high resolution, large depth of field and large visual angle can be obtained, moreover, the safety coefficient is high, the system size is small, and convenience is brought for calibration.

Three-dimensional display method and system with high information flux and low crosstalk

Abstract: The invention relates to a three-dimensional display method and system with high information flux and low crosstalk. A timing directional illumination module outputs illumination light of different directions according to a certain time series. The illumination light illuminates a light field display system formed by a display and a lens array from different angles. The light field display systemdisplays light field information of three-dimensional images of specified viewing angle ranges under illumination light of specified directions. The illumination light directions of the specified directions correspond to the specified viewing angle ranges one to one. The refresh timing sequence of the images displayed on the display of the light field display system are synchronously matched withthe illumination timing sequence of the timing directional illumination module, and three-dimensional image information in the same viewing angle range is superimposed and synthesized into a high-spatial-resolution three-dimensional image by time division multiplexing. According to the three-dimensional display system and method provided by the present invention, the three-dimensional image with ahigh resolution, a large viewing range and a large depth of field is provided, crosstalk noise does not exist, the image contrast is high, and the structure of the three-dimensional display system issimple.

Augmented reality display system using modulated moiré imaging technique.

Abstract: To enhance the depth rendering ability of augmented reality (AR) display systems, a modulated moire imaging technique is used to render the true three-dimensional (3D) images for AR display systems. 3D images with continuous depth information and large depth of field are rendered and superimposed on the real scene. The proposed AR system consists of a modulated moire imaging subsystem and an optical combiner. The modulated moire imaging subsystem employs modulated point light sources, a display device, and a microlens array to generate 3D images. A defocussing equal period moire imaging structure is used, which gives a chance for the point light sources to modulate the depth position of 3D images continuously. The principles of the imaging system are deduced analytically. A custom-designed transparent off-axis spherical reflective lens is used as an optical combiner to project the 3D images into the real world. An experimental AR system that provides continuous 3D images with depth information ranging from 0.5 to 2.5 m is made to verify the feasibility of the proposed technique.

Diffraction projection method and system

Abstract: The invention relates to a diffraction projection method and system. A point light source or a collimation light source illuminates an image source, the image source displays a to-be-projected targetimage, the to-be-projected target image is directly set on or transmitted by an optical system to an input surface or a front focal plane of a Fourier transform lens group, a Fourier spectrum of the to-be-projected target image is formed on an output surface or a back focal plane of the Fourier transform lens group, the Fourier spectrum is propagated forwards through diffraction, and a target image is formed at a certain distance. According to the projection method, projection imaging is achieved by means of the diffraction process, the using amount of lenses is decreased, and then the size ofthe projection system is effectively decreased; and the instability brought by a high-frequency dynamic scanning device is avoided, computing is not needed, coherent light illumination is not needed,and the image is clear and has the infinite depth of field.

Dual-imaging method and system of Fourier transform array and application thereof

Abstract: The invention relates to a dual-imaging method and system of a Fourier transform array and application. According to the dual-imaging method, rays emitted by a light source illuminate a focusing element array layer and a micro image-text array layer, and through a convergence focusing effect of a focusing element, a series of image points of the light source are formed near a focal point of the focusing element array. The rays emitted by the light source penetrate through the micro image-text array layer two times, two sets of Fourier transform spectra are formed, and moire images are formed separately. The dual-imaging method and system of the Fourier transform array have special photoresponse and can be applied to the fields of information and image processing, anti-counterfeiting security, packaging, decoration and the like.

Fast parallel algorithms for short-range molecular dynamics

Abstract: Three parallel algorithms for classical molecular dynamics are presented. The first assigns each processor a fixed subset of atoms; the second assigns each a fixed subset of inter-atomic forces to compute; the third assigns each a fixed spatial region. The algorithms are suitable for molecular dynamics models which can be difficult to parallelize efficiently—those with short-range forces where the neighbors of each atom change rapidly. They can be implemented on any distributed-memory parallel machine which allows for message-passing of data between independently executing processors. The algorithms are tested on a standard Lennard-Jones benchmark problem for system sizes ranging from 500 to 100,000,000 atoms on several parallel supercomputers--the nCUBE 2, Intel iPSC/860 and Paragon, and Cray T3D. Comparing the results to the fastest reported vectorized Cray Y-MP and C90 algorithm shows that the current generation of parallel machines is competitive with conventional vector supercomputers even for small problems. For large problems, the spatial algorithm achieves parallel efficiencies of 90% and a 1840-node Intel Paragon performs up to 165 faster than a single Cray C9O processor. Trade-offs between the three algorithms and guidelines for adapting them to more complex molecular dynamics simulations are also discussed.

Novel peptide linkers for highly potent antibody-auristatin conjugates

Abstract: 4907 A great deal of interest has surrounded the use of monoclonal antibodies (mAbs) for the selective delivery of cytotoxic agents to tumor cells. We have previously demonstrated that mAb-auristatin conjugates are highly active, leading to cures and regressions of established tumors in nude mice. These antibody-drug conjugates (ADCs) contain a dipeptide valine-citrulline-p-aminobenzylcarbamate (vc-PABC) linker used to join the antimitotic drugs monomethylauristatin E or F (MMAE, MMAF) to a series of antitumor mAbs. This linker was selected for plasma stability and cleavage by lysosomal enzymes such as cathepsin B. Here, we describe several other dipeptide sequences, many of which are not cathepsin B substrates, for the attachment of auristatins to mAb carriers. More than 20 mAb-dipeptide-PABC-MMAF ADCs were prepared, all of which were active in vitro and in vivo independent of peptide sequence. There was no apparent improvement over the vc-PABC linker, since the PABC group facilitated lysosomal drug release. In contrast, a new series of mAb-MMAF conjugates was prepared in which the dipeptide linkers were directly attached to the C-terminal phenylalanine on the drug without using an intervening PABC spacer. Many of the dipeptide sequences contained unnatural amino acids in order to increase the stringency of drug release. Peptide sequences were identified within the new conjugates that led to both greater tolerability and higher potency compared to corresponding vc-PABC ADCs. The new linkers play an important role in ADC activity and tolerability, and mAb-auristatin conjugates derived from them are candidates for future development.

Brain penetrating peptides and peptide–drug conjugates to overcome the blood–brain barrier and target CNS diseases

Abstract: Nearly one in six people worldwide suffer from disorders of the central nervous system (CNS). There is an urgent need for effective strategies to improve the success rates in CNS drug discovery and development. The lack of effective technologies for delivering drugs and genes to the brain due to the blood-brain barrier (BBB), a structural barrier that effectively blocks most neurotherapeutic agents from reaching the brain, has posed a formidable hurdle for CNS drug development. Brain-homing and brain-penetrating molecular transport vectors, such as brain permeable peptides or BBB shuttle peptides, have shown promise in overcoming the BBB and ferrying the drug molecules to the brain. The BBB shuttle peptides are discovered by phage display technology or derived from natural neurotropic proteins or certain viruses and harness the receptor-mediated transcytosis molecular machinery for crossing the BBB. Brain permeable peptide-drug conjugates (PDCs), composed of BBB shuttle peptides, linkers, and drug molecules, have emerged as a promising CNS drug delivery system by taking advantage of the endogenous transcytosis mechanism and tricking the brain into allowing these bioactive molecules to pass the BBB. Here, we examine the latest development of brain-penetrating peptide shuttles and brain-permeable PDCs as molecular vectors to deliver small molecule drug payloads across the BBB to reach brain parenchyma. Emerging knowledge of the contribution of the peptides and their specific receptors expressed on the brain endothelial cells, choice of drug payloads, the design of PDCs, brain entry mechanisms, and delivery efficiency to the brain are highlighted. This article is categorized under: Therapeutic Approaches and Drug Discovery > Emerging Technologies Therapeutic Approaches and Drug Discovery > Nanomedicine for Neurological Disease.

pH-Responsive Polypeptide-Based Smart Nano-Carriers for Theranostic Applications

Abstract: Smart nano-carriers have attained great significance in the biomedical field due to their versatile and interesting designs with different functionalities. The initial stages of the development of nanocarriers mainly focused on the guest loading efficiency, biocompatibility of the host and the circulation time. Later the requirements of less side effects with more efficacy arose by attributing targetability and stimuli-responsive characteristics to nano-carriers along with their bio- compatibility. Researchers are utilizing many stimuli-responsive polymers for the better release of the guest molecules at the targeted sites. Among these, pH-triggered release achieves increasing importance because of the pH variation in different organ and cancer cells of acidic pH. This specific feature is utilized to release the guest molecules more precisely in the targeted site by designing polymers having specific functionality with the pH dependent morphology change characteristics. In this review, we mainly concert on the pH-responsive polypeptides and some interesting nano-carrier designs for the effective theranostic applications. Also, emphasis is made on pharmaceutical application of the different nano-carriers with respect to the organ, tissue and cellular level pH environment.