W
Wu Yin
Researcher at Nanjing University
Publications - 31
Citations - 647
Wu Yin is an academic researcher from Nanjing University. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 9, co-authored 26 publications receiving 525 citations. Previous affiliations of Wu Yin include Nanjing University of Chinese Medicine.
Papers
More filters
Journal ArticleDOI
Analgesic and anti-inflammatory properties of brucine and brucine N-oxide extracted from seeds of Strychnos nux-vomica.
TL;DR: The results suggest that central and peripheral mechanism are involved in the pain modulation and anti-inflammation effects of brucine and Brucine N-oxide, biochemical mechanisms of bru cine and brucines N -oxide are different even though they are similar in chemical structure.
Journal ArticleDOI
The anti-tumor effects of alkaloids from the seeds of Strychnos nux-vomica on HepG2 cells and its possible mechanism
Xu-Kun Deng,Wu Yin,Weidong Li,Fangzhou Yin,Xiaoyu Lu,Xiao-Chun Zhang,Zi-Chun Hua,Baochang Cai +7 more
TL;DR: It is indicated that the major alkaloids present in the seed of Strychnos nux-vomica are effective against HepG2 cells proliferation, among which brucine proceed HepG 2 cells death via apoptosis, probably through the participation of caspase-3 and cyclooxygenase-2.
Journal ArticleDOI
The cytotoxicity induced by brucine from the seed of Strychnos nux-vomica proceeds via apoptosis and is mediated by cyclooxygenase 2 and caspase 3 in SMMC 7221 cells.
TL;DR: It is indicated that the major alkaloids present in the seed of Strychnos nux-vomica are effective against SMMC-7721 cells proliferation, among which brucine proceeds SMMC 7721 cells death via apoptosis, probably through the participation of caspase 3 and cyclooxygenase 2.
Journal ArticleDOI
Polyethylenimine-complexed Plasmid Particles Targeting Focal Adhesion Kinase Function as Melanoma Tumor Therapeutics
Shufeng Li,Wei Dong,Wei Dong,Yiwei Zong,Wu Yin,Guang-Hui Jin,Qingang Hu,Xiaofeng Huang,Wenhui Jiang,Zi-Chun Hua +9 more
TL;DR: Results indicate that intratumoral delivery of plasmid DNA targeting FAK function, using M-PEI as a gene carrier, represents a promising avenue for melanoma therapy.
Journal ArticleDOI
Reversal of the Apoptotic Resistance of Non-Small-Cell Lung Carcinoma towards TRAIL by Natural Product Toosendanin
Xin Li,Ming You,Yong-jian Liu,Lin Ma,Pei-pei Jin,Ri Zhou,Zhaoxin Zhang,Baojin Hua,Ji Xiaojun,Xiao-ying Cheng,Fangzhou Yin,Yan Chen,Yan Chen,Wu Yin,Wu Yin +14 more
TL;DR: TSN can be used to sensitize tumors and the combination of TRAIL and TSN may represent a useful strategy for NSCLC therapy; moreover, autophagy serves as an important drug resistance mechanism for TSN.