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Wylie Vale

Researcher at Salk Institute for Biological Studies

Publications -  877
Citations -  114263

Wylie Vale is an academic researcher from Salk Institute for Biological Studies. The author has contributed to research in topics: Receptor & Somatostatin. The author has an hindex of 163, co-authored 876 publications receiving 111935 citations. Previous affiliations of Wylie Vale include Texas Tech University Health Sciences Center & Hammersmith Hospital.

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Journal ArticleDOI

Characterization of a 41-residue ovine hypothalamic peptide that stimulates secretion of corticotropin and beta-endorphin

Wylie Vale, +3 more
- 18 Sep 1981 - 
TL;DR: A peptide with high potency and intrinsic activity for stimulating the secretion of corticotropin-like and β-endorphinlike immunoactivities by cultured anterior pituitary cells has been purified in this paper.
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Hypothalamic Polypeptide That Inhibits the Secretion of Immunoreactive Pituitary Growth Hormone

Paul Brazeau, +6 more
- 05 Jan 1973 - 
TL;DR: A peptide has been isolated from ovine hypothalamus which, at 1 x 10-9M, inhibits secretion in vitro of immunoreactive rat or human growth hormones and is similarly active in vivo in rats.
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Production of a novel neuropeptide encoded by the calcitonin gene via tissue-specific RNA processing

Michael G. Rosenfeld, +7 more
- 14 Jul 1983 - 
TL;DR: The approach described here permits the application of recombinant DNA technology to analyses of complex neurobiological systems in the absence of prior structural or biological information.
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Organization of Ovine Corticotropin-Releasing Factor Immunoreactive Cells and Fibers in the Rat Brain: An Immunohistochemical Study

Larry W. Swanson, +3 more
- 01 Jan 1983 - 
TL;DR: The results suggest that the PVH plays a critical role in the modulation of ACTH and beta-endorphin release from the pituitary, and that CRF-containing pathways in the brain are involved in the mediation of autonomic responses.
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Elevated concentrations of CSF corticotropin-releasing factor-like immunoreactivity in depressed patients

Charles B. Nemeroff, +8 more
- 14 Dec 1984 - 
TL;DR: Findings are concordant with the hypothesis that CRF hypersecretion is, at least in part, responsible for the hyperactivity of the hypothalamo-pituitary-adrenal axis characteristic of major depression.