X
Xi Chen
Researcher at Southern University of Science and Technology
Publications - 48
Citations - 3912
Xi Chen is an academic researcher from Southern University of Science and Technology. The author has contributed to research in topics: Chromatin & Immune system. The author has an hindex of 19, co-authored 43 publications receiving 2939 citations. Previous affiliations of Xi Chen include University of Manchester & Wellcome Trust Sanger Institute.
Papers
More filters
Journal ArticleDOI
A rapid and robust method for single cell chromatin accessibility profiling
Xi Chen,Ricardo J. Miragaia,Ricardo J. Miragaia,Kedar Nath Natarajan,Sarah A. Teichmann,Sarah A. Teichmann +5 more
TL;DR: A simple and robust plate-based single-cell ATAC-seq method that works in fresh and cryopreserved cells and identifies distinct immune cell types and reveal cell type-specific regulatory regions and related transcription factors is developed.
Journal ArticleDOI
Single-Cell Transcriptomics of Regulatory T Cells Reveals Trajectories of Tissue Adaptation.
Ricardo J. Miragaia,Tomás Gomes,Agnieszka Chomka,Laura Jardine,Angela Riedel,Ahmed N. Hegazy,Ahmed N. Hegazy,Natasha Whibley,Andrea Tucci,Xi Chen,Ida Lindeman,Guy Emerton,Thomas Krausgruber,Thomas Krausgruber,Jacqueline D. Shields,Muzlifah Haniffa,Fiona Powrie,Fiona Powrie,Sarah A. Teichmann,Sarah A. Teichmann,Sarah A. Teichmann +20 more
TL;DR: It is shown that Treg cells segregate into subpopulations along a continuum of tissue adaptation and present conserved expression programs between homeostasis and disease and mouse and human.
Journal ArticleDOI
Tumors induce de novo steroid biosynthesis in T cells to evade immunity
Bidesh Mahata,Bidesh Mahata,Jhuma Pramanik,Louise van der Weyden,Krzysztof Polanski,Gozde Kar,Gozde Kar,Angela Riedel,Xi Chen,Nuno A. Fonseca,Kousik Kundu,Kousik Kundu,Lia S. Campos,Edward Ryder,Graham Duddy,Izabela Walczak,Klaus Okkenhaug,David J. Adams,Jacqueline D. Shields,Sarah A. Teichmann +19 more
TL;DR: This study demonstrates T cell de novo steroidogenesis as a mechanism of anti-tumor immunosuppression and a potential druggable target and shows that genetic inactivation or pharmacological inhibition of tumor-induced Th2-mediated de noovo steroidogenesis are sufficient to restore an efficient anti-Tumor immune response and restrict tumor growth.
Journal ArticleDOI
Single-cell RNA-seq identifies a PD-1 hi ILC progenitor and defines its development pathway
Yong Yu,Jason C. H. Tsang,Jason C. H. Tsang,Cui Wang,Simon Clare,Juexuan Wang,Xi Chen,Cordelia Brandt,Leanne Kane,Lia S. Campos,Liming Lu,Gabrielle T. Belz,Andrew N. J. McKenzie,Sarah A. Teichmann,Sarah A. Teichmann,Gordon Dougan,Gordon Dougan,Pentao Liu +17 more
TL;DR: A perspective for exploring PD-1 and its ligand (PD-L1) in immunotherapy is provided, and single-cell RNA-sequencing of mouse bone marrow progenitors allows effective manipulation of the immune system for disease prevention and therapy.
Journal ArticleDOI
Establishment of porcine and human expanded potential stem cells
Xuefei Gao,Xuefei Gao,Monika Nowak-Imialek,Monika Nowak-Imialek,Xi Chen,Dongsheng Chen,Doris Herrmann,Doris Herrmann,Degong Ruan,Degong Ruan,Andy Chun Hang Chen,Mélanie A. Eckersley-Maslin,Shakil Ahmad,Yin Lau Lee,Toshihiro Kobayashi,David Ryan,Jixing Zhong,Jiacheng Zhu,Jian Wu,Guocheng Lan,Stoyan Petkov,Stoyan Petkov,Stoyan Petkov,Jian Yang,Jian Yang,Liliana Antunes,Lia S. Campos,Beiyuan Fu,Shengpeng Wang,Yu Yong,Xiaomin Wang,Song-Guo Xue,Ge Liangpeng,Liu Zuohua,Yong Huang,Tao Nie,Peng Li,Donghai Wu,Duanqing Pei,Yi Zhang,Liming Lu,Fengtang Yang,Susan J. Kimber,Wolf Reik,Xiangang Zou,Zhouchun Shang,Liangxue Lai,Azim Surani,Patrick P.L. Tam,Asif Ahmed,William S.B. Yeung,Sarah A. Teichmann,Heiner Niemann,Heiner Niemann,Pentao Liu,Pentao Liu +55 more
TL;DR: The derivation of porcine EPSCs, which express key pluripotency genes, are genetically stable, permit genome editing, differentiate to derivatives of the three germ layers in chimeras and produce primordial germ cell-like cells in vitro are reported.