Author
Xiang-Hai Cai
Other affiliations: Kunming Institute of Botany
Bio: Xiang-Hai Cai is an academic researcher from Chinese Academy of Sciences. The author has contributed to research in topics: Alstonia scholaris & Melodinus. The author has an hindex of 24, co-authored 95 publications receiving 1838 citations. Previous affiliations of Xiang-Hai Cai include Kunming Institute of Botany.
Topics: Alstonia scholaris, Melodinus, Picrinine, Erythrina, Tabernaemontana
Papers
More filters
TL;DR: The alkaloid fraction of Alstonia scholaris leaf, three main alkaloids, picrinine, vallesamine and scholaricine, may produce the anti-inflammatory and analgesic effect peripherally based on several in vivo assays.
155 citations
TL;DR: An unprecedented cage-like alkaloid, scholarisine A was isolated from the leaves of Alstonia scholaris and its structure determined on the basis of 1D and 2D NMR, FTIR, UV, and high-resolution mass spectroscopic data.
136 citations
TL;DR: A pair of geometrically isomeric monoterpenoid indole alkaloids with a skeleton rearrangement and two additional carbons were obtained from the leaf extract of Alstonia scholaris and their structures were elucidated on the basis of spectroscopic methods and then confirmed by X-ray crystal diffraction.
113 citations
TL;DR: The alkaloids fraction was anti-tussive, anti-asthmatic and expectorant activities component of Alstonia scholaris leaf, and it may also be a valuable lead material for respiratory diseases drug development.
100 citations
TL;DR: Nineteen monoterpenoid indole alkaloids including seven new ones, melodinines A-G (1-7), were isolated from Melodinus henryi and the structures of the new compounds were elucidated using spectroscopic methods, and the structure of compound 4 was confirmed by single-crystal X-ray diffraction analysis.
Abstract: Nineteen monoterpenoid indole alkaloids including seven new ones, melodinines A−G (1−7), were isolated from Melodinus henryi. The structures of the new compounds were elucidated using spectroscopic methods, and the structure of compound 4 was confirmed by single-crystal X-ray diffraction analysis. The known compounds were identified by comparing their spectroscopic data with those reported in the literature. All of the compounds were evaluated for cytotoxic activity against five human cancer cell lines, and compound 11 exhibited cytotoxicity against HL-60, SMMC-7721, A-549, and SK-BR-3 cells with IC50 values of 2.0, 16.8, 25.9, and 24.7 μM, respectively.
90 citations
Cited by
More filters
TL;DR: This Review is intended to draw a logical link between flow and batch reactions-a combination that leads to the current state of (1)O2 in synthesis.
Abstract: This Review describes singlet oxygen (1O2) in the organic synthesis of targets on possible 1O2 biosynthetic routes. The visible-light sensitized production of 1O2 is not only useful for synthesis; it is extremely common in nature. This Review is intended to draw a logical link between flow and batch reactions—a combination that leads to the current state of 1O2 in synthesis.
442 citations
TL;DR: Results indicate that betulin given i.p. has a similar efficacy in attenuating the neuromuscular effects of B. jararacussu venom in vivo and could be a useful complementary measure to antivenom therapy for treating snakebite.
Abstract: We confirmed the ability of the triterpenoid betulin to protect against neurotoxicity caused by Bothrops jararacussu snake venom in vitro in mouse isolated phrenic nerve-diaphragm (PND) preparations and examined its capability of in vivo protection using the rat external popliteal/sciatic nerve-tibialis anterior (EPSTA) preparation. Venom caused complete, irreversible blockade in PND (40 μg/mL), but only partial blockade (~30%) in EPSTA (3.6 mg/kg, i.m.) after 120 min. In PND, preincubation of venom with commercial bothropic antivenom (CBA) attenuated the venom-induced blockade, and, in EPSTA, CBA given i.v. 15 min after venom also attenuated the blockade (by ~70% in both preparations). Preincubation of venom with betulin (200 μg/mL) markedly attenuated the venom-induced blockade in PND; similarly, a single dose of betulin (20 mg, i.p., 15 min after venom) virtually abolished the venom-induced decrease in contractility. Plasma creatine kinase activity was significantly elevated 120 min after venom injection in the EPSTA but was attenuated by CBA and betulin. These results indicate that betulin given i.p. has a similar efficacy as CBA given i.v. in attenuating the neuromuscular effects of B. jararacussu venom in vivo and could be a useful complementary measure to antivenom therapy for treating snakebite.
373 citations
TL;DR: This paper aims to demonstrate the efforts towards in-situ applicability of EMMARM, as to provide real-time information about concrete mechanical properties such as E-modulus and compressive strength.
Abstract: Natural Science Foundation of China[30000213, 30370160, 30670214]; National Basic Research Program of China (973 Program)[2009CB522300]; Chinese Academy of Sciences
372 citations