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Xiang-Yao Li
Researcher at Zhejiang University
Publications - 51
Citations - 2380
Xiang-Yao Li is an academic researcher from Zhejiang University. The author has contributed to research in topics: Long-term potentiation & Anterior cingulate cortex. The author has an hindex of 22, co-authored 49 publications receiving 1858 citations. Previous affiliations of Xiang-Yao Li include Xi'an Jiaotong University & Chinese Academy of Sciences.
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Journal ArticleDOI
Sleep deprivation impairs cAMP signalling in the hippocampus
Christopher G. Vecsey,George S. Baillie,Devan Jaganath,Robbert Havekes,Andrew Daniels,Mathieu E. Wimmer,Ted Huang,Kim M. Brown,Xiang-Yao Li,Giannina Descalzi,Susan S. Kim,Tao Chen,Yuze Shang,Min Zhuo,Miles D. Houslay,Ted Abel +15 more
TL;DR: It is demonstrated that brief sleep deprivation disrupts hippocampal function by interfering with cAMP signalling through increased PDE4 activity, and drugs that enhance camp signalling may provide a new therapeutic approach to counteract the cognitive effects of sleep deprivation.
Journal ArticleDOI
Alleviating Neuropathic Pain Hypersensitivity by Inhibiting PKMζ in the Anterior Cingulate Cortex
Xiang-Yao Li,Xiang-Yao Li,Hyoung-Gon Ko,Tao Chen,Tao Chen,Giannina Descalzi,Kohei Koga,Hansen Wang,Susan S. Kim,Yuze Shang,Chuljung Kwak,Soowon Park,Jaehoon Shim,Jaehoon Shim,Kyungmin Lee,Kyungmin Lee,Graham L. Collingridge,Graham L. Collingridge,Bong-Kiun Kaang,Bong-Kiun Kaang,Min Zhuo,Min Zhuo +21 more
TL;DR: It is found that protein kinase M zeta (PKMζ) maintains pain-induced persistent changes in the mouse anterior cingulate cortex (ACC) and could be a new therapeutic target for treating chronic pain.
Journal ArticleDOI
A neural circuit for comorbid depressive symptoms in chronic pain
Wenjie Zhou,Yan Jin,Qian Meng,Xia Zhu,Tongjian Bai,Yanghua Tian,Yu Mao,Yu Mao,Likui Wang,Wen Xie,Hui Zhong,Na Zhang,Min-Hua Luo,Wenjuan Tao,Haitao Wang,Jie Li,Juan Li,Bensheng Qiu,Jiang-Ning Zhou,Xiang-Yao Li,Han Xu,Kai Wang,Xiaochu Zhang,Yong Liu,Gal Richter-Levin,Lin Xu,Zhi Zhang +26 more
TL;DR: A novel 5-HT circuit from the dorsal raphe nucleus to somatostatin-expressing neurons in the central nucleus of the amygdala that partially mediates depressive-like behavior in a mouse model of chronic pain is reported.
Journal ArticleDOI
Ultrasonic Control of Neural Activity through Activation of the Mechanosensitive Channel MscL
Jia Ye,Siyang Tang,Long Meng,Xia Li,Xiaoxu Wen,Sihan Chen,Lili Niu,Xiang-Yao Li,Weibao Qiu,Hailan Hu,Mizu Jiang,Shiqiang Shang,Qiang shu,Hairong Zheng,Shumin Duan,Yuezhou Li +15 more
TL;DR: Because MscL opens to tension in the lipid bilayer, requiring no other proteins or ligands, it could be developed into a general noninvasive sonogenetic tool to manipulate the activities of neurons or other cells and potential nanodevices.
Journal ArticleDOI
Ca2+ signaling evoked by activation of Na+ channels and Na+/Ca2+ exchangers is required for GABA-induced NG2 cell migration
TL;DR: GABAergic signaling mediated by sequential activation of GABAA receptors, noninactivating Na+ channels, and NCXs may play an important role in the development and function of NG2 glial cells in the brain.