Author
Xiangyang Sun
Bio: Xiangyang Sun is an academic researcher from Shandong University. The author has contributed to research in topics: Cancer. The author has an hindex of 1, co-authored 1 publications receiving 5 citations.
Topics: Cancer
Papers
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TL;DR: In this article, the authors summarize the recent advances in 1,2,3-triazole-containing compounds with anti-lung cancer potential, and their structure-activity relationship (SAR) together with mechanisms of action is also discussed to pave the way for the further rational development of novel anti-Lung cancer candidates.
Abstract: Lung cancer is the most common malignancy and leads to around one-quarter of all cancer deaths. Great advances have been achieved in the treatment of lung cancer with novel anticancer agents and improved technology. However, morbidity and mortality rates remain extremely high, calling for an urgent need to develop novel anti-lung cancer agents. 1,2,3-Triazole could be readily interact with diverse enzymes and receptors in organisms through weak interaction. 1,2,3-Triazole not only can be acted as a linker to tether different pharmacophores, but also can serve as a pharmacophore. This review aims to summarize the recent advances in 1,2,3-triazole-containing compounds with anti-lung cancer potential, and their structure-activity relationship (SAR) together with mechanisms of action is also discussed to pave the way for the further rational development of novel anti-lung cancer candidates.
29 citations
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TL;DR: In this paper, the authors present an overview of the recent advances in 1,2,3-triazole hybrids with anticancer potential over the last two years, their chemical structures, structure-activity relationships, and mechanisms of action.
Abstract: Despite the advancements in the development of anticancer agents, more effective and safer anticancer drugs still need to be developed as the current agents cause unwanted side effects and many patients have become drug resistant. 1,2,3-Triazoles, due to their remarkable biological potential, have received considerable attention in drug discovery for the development of anticancer agents. The present review article presents an overview of the recent advances in 1,2,3-triazole hybrids with anticancer potential over the last 2 years, their chemical structures, structure-activity relationships, and mechanisms of action, as well as insights into the docking studies.
56 citations
TL;DR: In this paper , the authors reported the synthesis of a new set of suggested anticancer molecules by joining the 1,2,3-triazole and chalcone privileged fragments in one scaffold to develop novel candidates in leukemia therapy.
22 citations
TL;DR: An efficient and convenient click synthesis of novel series of chromene scaffold linked to 1,2,3 triazole ring and terminal lipophilic fragments as potent and selective hit for treatment of breast cancers after processing of optimization steps is reported.
13 citations
TL;DR: In this article , the authors reported an efficient and convenient click synthesis of novel series of chromene scaffold linked to 1,2,3 triazole ring and terminal lipophilic fragments.
12 citations
TL;DR: A new set of 1,2,3-triazoles was designed and synthesized to evaluate their potential to inhibit the growth of cancer cells.
Abstract: A new set of 1,2,3-triazoles was designed and synthesized to evaluate their potential to inhibit the growth of cancer cells. Thiazole, thiazolone, and hydrazine as effective fragments presented in certain...
11 citations