Author
Xiangyu Zhang
Bio: Xiangyu Zhang is an academic researcher from Shenyang Pharmaceutical University. The author has contributed to research in topics: Demethylase & Pharmacophore. The author has an hindex of 6, co-authored 17 publications receiving 82 citations.
Papers
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TL;DR: The design, synthesis and biochemical evaluation of novel tetrahydroquinoline-based reversible LSD1 inhibitors are reported, and it is suggested that tetrahYDroquinolin-based LSD1 inhibitor deserve further investigation for the treatment of LSD1 overexpressing cancer.
29 citations
TL;DR: In this paper, a series of benzofuran derivatives were designed, synthesized and biochemical evaluated as novel LSD1 inhibitors based on scaffold hopping and conformational restriction strategy, and the representative compound 17i exhibited excellent LSD1 inhibition at the molecular levels with IC50 = 0.065μM, as well as anti-proliferation against MCF-7, MGC-803, H460, A549 and THP-1 tumor cells with IC 50 values of 2.90−±−0.32, 5.85−±-0.35
22 citations
TL;DR: Wang et al. as mentioned in this paper made an extensive review of the research obtained from the literature retrieval of electronic databases, such as PubMed, Web of Science, RCSB PDB, ClinicalTrials.gov, and EU clinical trials register, covering January 2015 to June 2021.
18 citations
TL;DR: It is suggested that compounds WA20 and WB07 are the first curcumin analogue-based LSD1 inhibitor with remarkable A549 suppressive activity, providing a novel scaffold for the development of LSD1 inhibitors.
18 citations
TL;DR: A molecular modeling study on a set of 43 thieno[3,2-b]pyrrole competitive inhibitors of LSD1 using three-dimensional quantitative structure-activity relationship (3D-QSAR), molecular docking and molecular dynamics simulations indicated the good predictive power and statistical reliability of this model.
Abstract: Lysine-specific demethylase 1 (LSD1) is a histone-modifying enzyme, which has been proposed as a promising target for anticancer drug development. Extensive research on LSD1 inhibitors has been per...
17 citations
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TL;DR: This review presents a survey on terrestrial and marine natural products modulating the PPARα system with the objective of highlighting how the incredible chemodiversity of natural products can provide innovative leads for this “hot” target.
105 citations
TL;DR: This review covers critically important developments in the field of β-carbolines, predominantly over the past decade (2006-2017), and includes key information on occurrence, structural diversity, and biological activities.
97 citations
TL;DR: Rutin, a bioflavonoid and the antibiotic, doxycycline, is identified as the most potent inhibitor of SARS-CoV-2 envelope protein, which is a essential role in the assembly and formation of the infectious virion particles.
83 citations
TL;DR: This review discusses the identification of natural LSD1 inhibitors, analysis of the co-crystal structures of LSD1/natural product complex, antitumor activity and their modes of action, and briefly discusses the challenges faced in this field.
64 citations
TL;DR: The authors in this article reviewed the various active pharmacophores of quinoline derivatives responsible for novel anticancer, anti-inflammatory, antibacterial, antiviral drug and superlative moiety in drug discovery.
61 citations