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Xianming Wu
Researcher at Chinese Academy of Sciences
Publications - 14
Citations - 285
Xianming Wu is an academic researcher from Chinese Academy of Sciences. The author has contributed to research in topics: Neural stem cell & Medicine. The author has an hindex of 6, co-authored 10 publications receiving 120 citations.
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Journal ArticleDOI
A collagen microchannel scaffold carrying paclitaxel-liposomes induces neuronal differentiation of neural stem cells through Wnt/β-catenin signaling for spinal cord injury repair.
Xiaoran Li,Caixia Fan,Zhifeng Xiao,Yannan Zhao,Haimin Zhang,Jie Sun,Yan Zhuang,Xianming Wu,Jiajia Shi,Yanyan Chen,Jianwu Dai,Jianwu Dai +11 more
TL;DR: It was demonstrated for the first time that PTX could rescue myelin-inhibited neuronal differentiation of NSCs, and induced a higher neuronal differentiation as compared with that in normal microenvironment, and the collagen microchannel scaffold in combination with sustained release of therapeutic agents is promising for SCI repair.
Journal ArticleDOI
A DAMP-scavenging, IL-10-releasing hydrogel promotes neural regeneration and motor function recovery after spinal cord injury.
B. D. Utebaev,He Shen,Claus Schmitt,Bai Xu,Chao Yang,Weiwei Xue,Zhifeng You,Xianming Wu,Dezun Ma,Dan Shao,Kam W. Leong,Jianwu Dai +11 more
TL;DR: In this paper, an immunoregulatory hydrogel scaffold was developed for treating spinal cord injury that scavenged DAMPs and slowly released the anti-inflammatory cytokine interleukin-10 (IL-10).
Journal ArticleDOI
Rapid and Efficient Conversion of Human Fibroblasts into Functional Neurons by Small Molecules.
Yaming Yang,Ruiguo Chen,Xianming Wu,Yannan Zhao,Yongheng Fan,Zhifeng Xiao,Jin Han,Le Sun,Xiaoqun Wang,Jianwu Dai +9 more
TL;DR: It is reported that human fibroblasts can be efficiently and directly reprogrammed into glutamatergic neuron-like cells by serially exposing cells to a combination of small molecules and this approach offers strategies for disease modeling and drug discovery in central nervous system disorders.
Journal ArticleDOI
Vascular endothelial growth factor activates neural stem cells through epidermal growth factor receptor signal after spinal cord injury.
Sumei Liu,Zhifeng Xiao,Xing Li,Yannan Zhao,Xianming Wu,Jin Han,Bing Chen,Jiayin Li,Caixia Fan,Bai Xu,Xiaoyu Xue,Weiwei Xue,Ying Yang,Jianwu Dai +13 more
TL;DR: This work noticed SCI elevated expression of vascular endothelial growth factor (VEGF) and aimed to validate the roles of VEGF in NSCs activation after SCI and investigated the related signals during the process.
Journal ArticleDOI
Epidermal growth factor receptor-extracellular-regulated kinase blockade upregulates TRIM32 signaling cascade and promotes neurogenesis after spinal cord injury.
Weiwei Xue,Yannan Zhao,Zhifeng Xiao,Xianming Wu,Dezun Ma,Jin Han,Xing Li,Xiaoyu Xue,Ying Yang,Yongxiang Fang,Caixia Fan,Sumei Liu,Bai Xu,Sufang Han,Bing Chen,Haipeng Zhang,Yongheng Fan,Weiyuan Liu,Qun Dong,Jianwu Dai +19 more
TL;DR: The results showed that EGFR‐ERK blockade antagonized MAI of neuronal differentiation of NSCs through regulation of TRIM32 by ERK, which may provide potential new targets for SCI repair.