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Xiaobo Wan
Researcher at University of California, San Francisco
Publications - 16
Citations - 607
Xiaobo Wan is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Kinase & Covalent bond. The author has an hindex of 9, co-authored 12 publications receiving 448 citations. Previous affiliations of Xiaobo Wan include Peking Union Medical College.
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Journal ArticleDOI
Broad-Spectrum Kinase Profiling in Live Cells with Lysine-Targeted Sulfonyl Fluoride Probes
Q Zhao,Xiaohu Ouyang,Xiaobo Wan,Ketan S. Gajiwala,John Charles Kath,Lyn H. Jones,Alma L. Burlingame,Jack Taunton +7 more
TL;DR: The design of sulfonyl fluoride probes that covalently label a broad swath of the intracellular kinome with high efficiency are reported, highlighting the utility of lysine-targeted sulfonyL fluoride probes in demanding chemoproteomic applications.
Journal ArticleDOI
Molecular Determinants of Enterovirus 71 Viral Entry CLEFT AROUND GLN-172 ON VP1 PROTEIN INTERACTS WITH VARIABLE REGION ON SCAVENGE RECEPTOR B 2
Pan Chen,Zilin Song,Yonghe Qi,Xiaofeng Feng,Naiqing Xu,Yinyan Sun,Xing Wu,Xin Yao,Qunyin Mao,Xiu-Ling Li,Wenjuan Dong,Xiaobo Wan,Niu Huang,Xin-Liang Shen,Zhenglun Liang,Wenhui Li +15 more
TL;DR: The viral capsid and receptor determinants of enterovirus 71 infection was elucidated and a possible target for antiviral interventions was revealed.
Journal ArticleDOI
Discovery of Lysine-Targeted eIF4E Inhibitors through Covalent Docking
Xiaobo Wan,Tangpo Yang,Adolfo Cuesta,Xiaming Pang,Trent E. Balius,John J. Irwin,Brian K. Shoichet,Jack Taunton +7 more
TL;DR: Arylsulfonyl fluoride 2 was elaborated to 12, which to the authors' knowledge is the first covalent eIF4E inhibitor with cellular activity and may offer a general strategy for developing selective, lysine-targeted covalENT ligands.
Journal ArticleDOI
A new target for an old drug: identifying mitoxantrone as a nanomolar inhibitor of PIM1 kinase via kinome-wide selectivity modeling.
TL;DR: A physics-based approach to computationally modeling the kinase inhibitor selectivity profile is described and the crystal complex structure of PIM1 bound with mitoxantrone is determined, which reveals the structural and mechanistic basis for a novel mode of Pim1 inhibition.
Journal ArticleDOI
Structural mechanism of ubiquitin and NEDD8 deamidation catalyzed by bacterial effectors that induce macrophage-specific apoptosis
Qing Yao,Jixin Cui,Jiayi Wang,Ting Li,Xiaobo Wan,Tianming Luo,Yi-Nan Gong,Ying Xu,Niu Huang,Feng Shao +9 more
TL;DR: An atomic view of how a bacterial deamidase effector, cycle-inhibiting factor homolog in Burkholderia pseudomallei (CHBP), recognizes its host targets, Ub and Ub-like neural precursor cell expressed, developmentally down-regulated 8 (NEDD8), and catalyzes site-specific deamidation is presented.