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Xiaodan Hou
Researcher at Shanghai Jiao Tong University
Publications - 4
Citations - 406
Xiaodan Hou is an academic researcher from Shanghai Jiao Tong University. The author has contributed to research in topics: Phosphorylation & Downregulation and upregulation. The author has an hindex of 3, co-authored 3 publications receiving 321 citations.
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Journal ArticleDOI
Metabolic reprogramming of cancer-associated fibroblasts by IDH3α downregulation.
Daoxiang Zhang,Daoxiang Zhang,Yongbin Wang,Zhimin Shi,Jingyi Liu,Pan Sun,Xiaodan Hou,Jian Zhang,Shimin Zhao,Binhua P. Zhou,Jun Mi +10 more
TL;DR: It is reported that TGF-β1- or PDGF-induced CAFs switch from oxidative phosphorylation to aerobic glycolysis, and downregulation of isocitrate dehydrogenase 3α (IDH3α) is identified as a marker for this switch.
Journal ArticleDOI
MiR-21/Smad 7 signaling determines TGF-β1-induced CAF formation
Qiong Li,Daoxiang Zhang,Yongbin Wang,Pan Sun,Xiaodan Hou,James M. Larner,Wujun Xiong,Jun Mi,Jun Mi +8 more
TL;DR: It is demonstrated that miR-21 and Smad7 are critical regulators of TGF-β1 signaling during the induction of CAF formation.
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TGFBR-IDH1-Cav1 axis promotes TGF-β signalling in cancer-associated fibroblast
TL;DR: It is reported that the TGFBR-IDH1-Cav1 axis promotes TGF- β signalling in fibroblasts, and downregulation of IDH1 increased cellular concentration of α-ketoglutarate (α-KG) by accelerating glutamine metabolization.
Journal ArticleDOI
The role of A-kinase interacting protein 1 in regulating progression and stemness as well as indicating the prognosis in glioblastoma
TL;DR: In this article , the effect of AKIP1 on GBM cell malignant behaviors, stemness, and its underlying molecular mechanisms was investigated, and it was found that AKIP 1 overexpression increased cell invasion, CD133+ cell proportion, and sphere formation ability while less affecting cell proliferation or cell apoptosis.