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Xiaofeng Zheng
Researcher at University of Texas MD Anderson Cancer Center
Publications - 22
Citations - 3525
Xiaofeng Zheng is an academic researcher from University of Texas MD Anderson Cancer Center. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 2, co-authored 2 publications receiving 2744 citations.
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Journal ArticleDOI
Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Reduced Survival.
Berna C. Özdemir,Berna C. Özdemir,Tsvetelina Pentcheva-Hoang,Julienne L. Carstens,Xiaofeng Zheng,Chia Chin Wu,Tyler R. Simpson,Hanane Laklai,Hikaru Sugimoto,Hikaru Sugimoto,Christoph Kahlert,Christoph Kahlert,Sergey V. Novitskiy,Ana De Jesus-Acosta,Padmanee Sharma,Pedram Heidari,Umar Mahmood,Lynda Chin,Harold L. Moses,Valerie M. Weaver,Anirban Maitra,James P. Allison,Valerie S. LeBleu,Valerie S. LeBleu,Raghu Kalluri,Raghu Kalluri +25 more
TL;DR: Although myofibroblast-depleted tumors did not respond to gemcitabine, anti-CTLA4 immunotherapy reversed disease acceleration and prolonged animal survival, and underscores the need for caution in targeting carcinoma-associated fibroblasts in PDAC.
Journal ArticleDOI
Epithelial-to-mesenchymal transition is dispensable for metastasis but induces chemoresistance in pancreatic cancer
Xiaofeng Zheng,Julienne L. Carstens,Jiha Kim,Matthew Scheible,Judith Kaye,Hikaru Sugimoto,Chia Chin Wu,Valerie S. LeBleu,Raghu Kalluri +8 more
TL;DR: This study functionally probes the role of EMT in PDAC by generating mouse models of PDAC with deletion of Snail or Twist, two key transcription factors responsible for EMT, and highlights the importance of combining EMT inhibition with chemotherapy for the treatment of pancreatic cancer.
Journal ArticleDOI
Identification of Functional Heterogeneity of Carcinoma-Associated Fibroblasts with Distinct IL-6 Mediated Therapy Resistance in Pancreatic Cancer.
Kathleen M. McAndrews,Yang Chen,Josephine Darpolor,Xiaofeng Zheng,Sujuan Yang,Julienne L. Carstens,Bingrui Li,Huamin Wang,Toru Miyake,Pedro Correa de Sampaio,Michelle L. Kirtley,Mariangela Natale,Chia Chin Wu,Hikaru Sugimoto,Valerie S. LeBleu,Raghu Kalluri +15 more
TL;DR: Improved gemcitabine efficacy due to lack of IL-6 synergizes with anti-PD1 immunotherapy to significantly improve survival of PDAC mice and identifies functional heterogeneity of CAFs in PDAC progression and their different roles in therapy response.
Journal ArticleDOI
Rapid acceleration of KRAS-mutant pancreatic carcinogenesis via remodeling of tumor immune microenvironment by PPARδ
Yi Liu,Yasunori Deguchi,Daoyan Wei,Fuyao Liu,Micheline Moussalli,Eriko Deguchi,Donghui Li,Huamin Wang,Lovie Ann Valentin,Jennifer K. Colby,Jing Wang,Xiaofeng Zheng,Haoqiang Ying,Mihai Gagea,Baoan Ji,Jiaqi Shi,James C. Yao,Xiangsheng Zuo,Imad Shureiqi +18 more
TL;DR: In this article , peroxisome proliferator-activated receptor-delta (PPARδ), a lipid nuclear receptor, is upregulated in PanINs in humans and mice.
Journal ArticleDOI
Construction and Analysis of the Complete Genome Sequence of Leprosy Agent Mycobacterium lepromatosis
TL;DR: The complete genome sequence of M. lepromatosis was constructed and annotated and new and refined insights into the genome size, gene repertoire, pseudogenes, phylogenomic relationship, genome organization and plasticity, process and timing of reductive evolution, and genetic and proteomic basis for pathogenesis were found.