Author
Xiaogang Liu
Other affiliations: Heilongjiang University, Massachusetts Institute of Technology, Nanjing University ...read more
Bio: Xiaogang Liu is an academic researcher from National University of Singapore. The author has contributed to research in topics: Medicine & Photon upconversion. The author has an hindex of 94, co-authored 425 publications receiving 41825 citations. Previous affiliations of Xiaogang Liu include Heilongjiang University & Massachusetts Institute of Technology.
Papers published on a yearly basis
Papers
More filters
••
TL;DR: FePS3 nanosheets (NSs) are explored for the first time as novel microenvironment-selective therapeutic nanoagents for bacterial biofilm infections with both self-enhanced Fenton activity for an anti-biofilm effect and reactive oxygen species (ROS) scavenging properties for anAnti-inflammatory effect.
Abstract: Bacterial biofilm infections are intractable to traditional antibiotic treatment and usually cause persistent inflammation. Chemodynamic therapy (CDT) based on the Fenton reaction has recently emerged as a promising anti-biofilm strategy. However, the therapeutic efficacy of current Fenton agents often suffers from inefficient Fenton activity and lacks anti-inflammatory capability. Herein, FePS3 nanosheets (NSs) are explored for the first time as novel microenvironment-selective therapeutic nanoagents for bacterial biofilm infections with both self-enhanced Fenton activity for an anti-biofilm effect and reactive oxygen species (ROS) scavenging properties for an anti-inflammatory effect. In biofilms with acidic microenvironments, FePS3 NSs release Fe2+ to generate toxic ROS by Fenton reaction and reductive [P2S6]4- to enhance the Fenton activity by reducing Fe3+ to Fe2+. In the surrounding normal tissues with neutral pH, FePS3 NSs scavenge ROS by reductive [P2S6]4- with an anti-inflammatory effect. This work demonstrates multifunctional Fenton nanoagents with microenvironment-selective ROS generation and elimination properties for effective treatment of bacterial biofilm infections with both anti-biofilm and anti-inflammatory effects.
39 citations
••
TL;DR: In this paper, a modified arc-discharge technique was used to synthesize FeCo nanocapsules with FeCo alloy as core and amorphous Al(2)O(3) as shell.
Abstract: FeCo nanocapsules with FeCo alloy as core and amorphous Al(2)O(3) as shell have been synthesized by a modified arc-discharge technique Three-dimensional coral-like aggregates are self-assembled by the nanocapsules in the arc-discharge process The FeCo nanocapsules are ferromagnetic at room temperature The electromagnetic-wave absorption properties of FeCo nanocapsules were investigated in the frequency range from 2 to 18 GHz A reflection loss exceeding -20 dB was obtained in the frequency range of 52-159 GHz for absorber thicknesses of 2-4 mm An optimal reflection loss of -448 dB was reached at 128 GHz for an absorber thickness of 3 mm As a result, these FeCo nanocapsules may be applied in high-frequency electromagnetic-wave absorption (C) 2008 American Institute of Physics [DOI: 101063/12982411]
39 citations
••
TL;DR: A localized electron enhanced ion transport mechanism to promote ion mobility for ultrafast energy storage is proposed, and experiment results reveal that this mechanism leads to an enhancement of Li/Na ion diffusivity by two orders of magnitude.
Abstract: The rate-determining process for electrochemical energy storage is largely determined by ion transport occurring in the electrode materials. Apart from decreasing the distance of ion diffusion, the enhancement of ionic mobility is crucial for ion transport. Here, a localized electron enhanced ion transport mechanism to promote ion mobility for ultrafast energy storage is proposed. Theoretical calculations and analysis reveal that highly localized electrons can be induced by intrinsic defects, and the migration barrier of ions can be obviously reduced. Consistently, experiment results reveal that this mechanism leads to an enhancement of Li/Na ion diffusivity by two orders of magnitude. At high mass loading of 10 mg cm-2 and high rate of 10C, a reversible energy storage capacity up to 190 mAh g-1 is achieved, which is ten times greater than achievable by commercial crystals with comparable dimensions.
39 citations
••
TL;DR: Sb-Doped SnO2 nanocrystals can be used as "all-in-one" type nanoagents for imaging guided photothermal ablation of tumors under the irradiation of a laser in the second bio-transparent window.
Abstract: Ideal theranostic nanoagents should be “all-in-one” type nanocrystals that have a single-semiconductor component and all-required properties (such as imaging and photothermal effects), but most semiconductor nanocrystals do not have these required properties. With SnO2 as a model of a typical wide-band semiconductor, we report the tuning from UV-responsive SnO2 to blue SnO2 nanocrystals with imaging ability and a Sb-doping-dependent photothermal effect. Sb-Doped SnO2 nanocrystals were prepared by heating SbCl3 and SnCl4 in benzyl alcohol solution through a facile solvothermal route. When the SbCl3/SnCl4 molar ratio increases from 0 to 0.2/1, the obtained samples exhibit an increased photothermal effect under the irradiation of a 1064 nm laser, accompanied by gradually decreased size and crystallinity. With a further increase of the molar ratio from 0.3/1.0 to 1.0/1.0, the resulting samples demonstrate the tetragonal SnO2 phase with amorphous-like compounds and they show no obvious enhancement of a photothermal effect. After a surface modification with biological molecules, the optimized Sb0.2-SnO2 nanocrystals demonstrated good stability and a high photothermal conversion efficiency of 48.3% as well as low cytotoxicity. When Sb0.2-SnO2 was injected into a tumor of mice, the tumor could be simultaneously detected by X-ray computed tomography (CT) and photoacoustic (PA) imaging, and then thermally ablated when exposed to a 1064 nm laser. Therefore, these nanocrystals can be used as “all-in-one” type nanoagents for imaging guided photothermal ablation of tumors under the irradiation of a laser in the second bio-transparent window.
39 citations
••
TL;DR: In this paper, the relationship between the structure and laser dye properties of four coumarin derivatives is investigated to assist in knowledge-based molecular design of coumarins for various optoelectronic applications.
Abstract: The relationships between the structure and laser dye properties of four coumarin derivatives are investigated to assist in knowledge-based molecular design of coumarins for various optoelectronic applications. Four new crystal structures of coumarins 343, 314T, 445, and 522B are determined at 120 K and analyzed via the empirical harmonic–oscillator–stabilization–energy and bond-length–alternation models, based on resonance theory. Results from these analyses are used to rationalize the optoelectronic properties of these coumarins, such as their UV–vis peak absorption wavelength, molar extinction coefficient, and fluorescence quantum efficiency. The specific molecular structural features of these four coumarins and the effects on their optoelectronic properties are further examined via a comparison with other similar coumarin derivatives, including coumarins 314, 500, and 522. These findings are corroborated by density functional theory (DFT) and time-dependent DFT calculations. The structure–property cor...
39 citations
Cited by
More filters
••
[...]
TL;DR: There is, I think, something ethereal about i —the square root of minus one, which seems an odd beast at that time—an intruder hovering on the edge of reality.
Abstract: There is, I think, something ethereal about i —the square root of minus one. I remember first hearing about it at school. It seemed an odd beast at that time—an intruder hovering on the edge of reality.
Usually familiarity dulls this sense of the bizarre, but in the case of i it was the reverse: over the years the sense of its surreal nature intensified. It seemed that it was impossible to write mathematics that described the real world in …
33,785 citations
•
28,685 citations
28 Jul 2005
TL;DR: PfPMP1)与感染红细胞、树突状组胞以及胎盘的单个或多个受体作用,在黏附及免疫逃避中起关键的作�ly.
Abstract: 抗原变异可使得多种致病微生物易于逃避宿主免疫应答。表达在感染红细胞表面的恶性疟原虫红细胞表面蛋白1(PfPMP1)与感染红细胞、内皮细胞、树突状细胞以及胎盘的单个或多个受体作用,在黏附及免疫逃避中起关键的作用。每个单倍体基因组var基因家族编码约60种成员,通过启动转录不同的var基因变异体为抗原变异提供了分子基础。
18,940 citations
••
TL;DR: Room-temperature ultraviolet lasing in semiconductor nanowire arrays has been demonstrated and self-organized, <0001> oriented zinc oxide nanowires grown on sapphire substrates were synthesized with a simple vapor transport and condensation process.
Abstract: Room-temperature ultraviolet lasing in semiconductor nanowire arrays has been demonstrated The self-organized, oriented zinc oxide nanowires grown on sapphire substrates were synthesized with a simple vapor transport and condensation process These wide band-gap semiconductor nanowires form natural laser cavities with diameters varying from 20 to 150 nanometers and lengths up to 10 micrometers Under optical excitation, surface-emitting lasing action was observed at 385 nanometers, with an emission linewidth less than 03 nanometer The chemical flexibility and the one-dimensionality of the nanowires make them ideal miniaturized laser light sources These short-wavelength nanolasers could have myriad applications, including optical computing, information storage, and microanalysis
8,592 citations
••
TL;DR: Physical structure is known to contribute to the appearance of bird plumage through structural color and specular reflection, but a third mechanism, structural absorption, leads to low reflectance and super black color in birds of paradise feathers.
Abstract: Many studies have shown how pigments and internal nanostructures generate color in nature. External surface structures can also influence appearance, such as by causing multiple scattering of light (structural absorption) to produce a velvety, super black appearance. Here we show that feathers from five species of birds of paradise (Aves: Paradisaeidae) structurally absorb incident light to produce extremely low-reflectance, super black plumages. Directional reflectance of these feathers (0.05-0.31%) approaches that of man-made ultra-absorbent materials. SEM, nano-CT, and ray-tracing simulations show that super black feathers have titled arrays of highly modified barbules, which cause more multiple scattering, resulting in more structural absorption, than normal black feathers. Super black feathers have an extreme directional reflectance bias and appear darkest when viewed from the distal direction. We hypothesize that structurally absorbing, super black plumage evolved through sensory bias to enhance the perceived brilliance of adjacent color patches during courtship display.
5,916 citations