Xiaoju Max Ma

TL;DR: Recent findings on the regulators and effectors of mTOR are highlighted and specific cases that serve as paradigms for the different modes of m TOR regulation and its control of translation are discussed.

TL;DR: A search for substrates of a growth-promoting kinase revealed a regulatory feedback loop involved in tumor suppression, and large-scale quantitative phosphoproteomics experiments were used to define the signaling networks downstream of mTORC1 and m TORC2.

TL;DR: SKAR-mediated recruitment of activated S6K1 to newly processed mRNPs serves as a conduit between mTOR checkpoint signaling and the pioneer round of translation when cells exist in conditions supportive of protein synthesis.

TL;DR: The relationship between 8-hydroxy-2'-deoxyguanosine (8-OHdG) levels and chemical exposure was estimated by Bayesian kernel machine regression (BKMR) models as discussed by the authors .

TL;DR: It is demonstrated that using liquid biopsies to measure early changes in ctDNA levels in response to chemotherapy may help identify non-responders before standard-of-care imaging in advanced NSCLC and monitor treatment efficacy earlier and accurately can enable more personalized regimens to improve patient outcomes.