X
Xiaoling Yang
Researcher at National Institutes of Health
Publications - 69
Citations - 8954
Xiaoling Yang is an academic researcher from National Institutes of Health. The author has contributed to research in topics: RNA-binding protein & Gene silencing. The author has an hindex of 43, co-authored 63 publications receiving 7959 citations. Previous affiliations of Xiaoling Yang include Laboratory of Molecular Biology & Government of the United States of America.
Papers
More filters
Journal ArticleDOI
LincRNA-p21 Suppresses Target mRNA Translation
Je Hyun Yoon,Kotb Abdelmohsen,Subramanya Srikantan,Xiaoling Yang,Jennifer L. Martindale,Supriyo De,Maite Huarte,Ming Zhan,Kevin G. Becker,Myriam Gorospe +9 more
TL;DR: It is proposed that HuR controls translation of a subset of target mRNAs by influencing lincRNA-p21 levels, which in turn derepressed JunB and β-catenin translation and increased the levels of these proteins.
Journal ArticleDOI
Phosphorylation of HuR by Chk2 regulates SIRT1 expression
Kotb Abdelmohsen,Rudolf Pullmann,Ashish Lal,Hyeon Ho Kim,Stefanie Galbán,Xiaoling Yang,Justin D. Blethrow,Mark Walker,Jonathan Shubert,David A. F. Gillespie,Henry Furneaux,Myriam Gorospe +11 more
TL;DR: The findings demonstrate that HuR regulates SIRT1 expression, underscore functional links between the two stress-response proteins, and implicate Chk2 in these processes.
Journal ArticleDOI
Identification of a target RNA motif for RNA-binding protein HuR
TL;DR: The identification of a 17- to 20-base-long RNA motif rich in uracils allowed the successful prediction and subsequent validation of novel HuR targets from gene databases and presents a general strategy for identifying target motifs for RNA-binding proteins.
Journal ArticleDOI
Concurrent versus individual binding of HuR and AUF1 to common labile target mRNAs
Ashish Lal,Krystyna Mazan-Mamczarz,Tomoko Kawai,Xiaoling Yang,Jennifer L. Martindale,Myriam Gorospe +5 more
TL;DR: The results indicate that the composition and fate of HuR‐ and/or AUF1‐containing ribonucleoprotein complexes depend on the target mRNA of interest, RNA‐binding protein abundance, stress condition, and subcellular compartment.
Journal ArticleDOI
Scaffold function of long non-coding RNA HOTAIR in protein ubiquitination
Je-Hyun Yoon,Kotb Abdelmohsen,Jiyoung Kim,Xiaoling Yang,Jennifer L. Martindale,Kumiko Tominaga-Yamanaka,Elizabeth J.F. White,Arturo V. Orjalo,John L. Rinn,Stefan G. Kreft,Gerald M. Wilson,Myriam Gorospe +11 more
TL;DR: A post-translational function for the lncRNA HOTAIR is reported as an inducer of ubiquitin-mediated proteolysis, causing rapid decay of targets Ataxin-1 and Snurportin- 1, and preventing premature senescence.