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Xiaoling Yuan
Researcher at Rutgers University
Publications - 8
Citations - 1359
Xiaoling Yuan is an academic researcher from Rutgers University. The author has contributed to research in topics: Kinase & MAPK/ERK pathway. The author has an hindex of 8, co-authored 8 publications receiving 1304 citations.
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Journal ArticleDOI
Inhibition of 7,12-dimethylbenz(a)anthracene-induced skin tumorigenesis in C57BL/6 mice by sulforaphane is mediated by nuclear factor E2-related factor 2.
Changjiang Xu,Mou-Tuan Huang,Guoxiang Shen,Xiaoling Yuan,Wen Lin,Tin Oo Khor,Allan H. Conney,Ah-Ng Tony Kong +7 more
TL;DR: The results show for the first time that Nrf2(-/-) mice are more susceptible to skin tumorigenesis and that the chemopreventive effects of sulforaphane are mediated, at least in part, through NRF2.
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Mechanism of Action of Sulforaphane: Inhibition of p38 Mitogen-Activated Protein Kinase Isoforms Contributing to the Induction of Antioxidant Response Element–Mediated Heme Oxygenase-1 in Human Hepatoma HepG2 Cells
Young-Sam Keum,Siwang Yu,Peter Chang,Xiaoling Yuan,Jung-Hwan Kim,Changjiang Xu,Jiahuai Han,Anupam Agarwal,Ah-Ng Tony Kong +8 more
TL;DR: Results indicate that transcriptional activation of Nrf2/ARE is critical in sulforaphane-mediated induction of HO-1, which can be modulated in part by the blockade of p38 MAPK signaling pathway.
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Mechanism of action of isothiocyanates: the induction of ARE-regulated genes is associated with activation of ERK and JNK and the phosphorylation and nuclear translocation of Nrf2.
Changjiang Xu,Xiaoling Yuan,Zui Pan,Guoxiang Shen,Jung-Hwan Kim,Siwang Yu,Tin Oo Khor,Wenge Li,Jianjie Ma,Ah-Ng Tony Kong +9 more
TL;DR: Results strongly suggest a model in which PEITC treatment of PC-3 cells activates ERK and JNK, which, in turn, phosphorylate Nrf2 and induce its translocation to the nucleus.
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ERK and JNK signaling pathways are involved in the regulation of activator protein 1 and cell death elicited by three isothiocyanates in human prostate cancer PC-3 cells
Changjiang Xu,Guoxiang Shen,Xiaoling Yuan,Jung-Hwan Kim,Avantika Gopalkrishnan,Young-Sam Keum,Sujit Nair,Ah-Ng Tony Kong +7 more
TL;DR: The results indicate that the activation of the ERK and JNK signaling pathways is important for transcriptional activity of AP-1 and is involved in the regulation of cell death elicited by ITCs in PC-3 cells.
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Butylated hydroxyanisole regulates ARE-mediated gene expression via Nrf2 coupled with ERK and JNK signaling pathway in HepG2 cells.
Xiaoling Yuan,Changjiang Xu,Zui Pan,Young-Sam Keum,Jung-Hwan Kim,Guoxiang Shen,Siwang Yu,Khor Tin Oo,Jianjie Ma,Ah-Ng Tony Kong +9 more
TL;DR: Results strongly suggested that ERK and JNK signaling pathways played important and positive roles in BHA‐induced and Nrf2‐dependent regulation of ARE‐mediated gene expression, as well as the nuclear translocation of NRF2 in HepG2 cells.