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Xiaolu Hsi

Bio: Xiaolu Hsi is an academic researcher from Beth Israel Deaconess Medical Center. The author has contributed to research in topics: Schizophrenia & Cognition. The author has an hindex of 6, co-authored 8 publications receiving 141 citations. Previous affiliations of Xiaolu Hsi include Massachusetts Institute of Technology.

Papers
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Journal ArticleDOI
TL;DR: This review views problems in declarative memory and hippocampal function from the perspective of elevated rates of common medical disorders in schizophrenia, with a focus on insulin insensitivity/diabetes and the likelihood that poor glucose regulation/availability contribute to declaratives memory deficits and hippocampusal abnormalities.

45 citations

Journal ArticleDOI
16 May 2012-PLOS ONE
TL;DR: The current study examined the experience of pleasure and emotional expression in college students who demonstrated high and low levels of schizotypal personality disorder (SPD) traits on self-report questionnaires.
Abstract: Difficulties in feeling pleasure and expressing emotions are one of the key features of schizophrenia spectrum conditions, and are significant contributors to constricted interpersonal interactions. The current study examined the experience of pleasure and emotional expression in college students who demonstrated high and low levels of schizotypal personality disorder (SPD) traits on self-report questionnaires. One hundred and seventeen subjects with SPD traits and 116 comparison controls were recruited to participate. Cluster analyses conducted in the SPD group identified negative SPD and positive SPD subgroups. The negative SPD group exhibited deficient emotional expression and anticipatory pleasure, but showed intact consummatory pleasure. The positive SPD group reported significantly greater levels of anticipatory, consummatory and total pleasure compared to the control group. Both SPD groups reported significantly more problems in everyday memory and greater levels of depressive and anxiety-related symptoms.

34 citations

Journal ArticleDOI
TL;DR: The study showed that cumulative declines in daytime vigilance resulted from loss of total sleep time, rather than from specific stages, and underscored the reversibility of SR effects with greater amounts of sleep.
Abstract: Sleep is regulated by complex biological systems and environmental influences, neither of which is fully clarified. This study demonstrates differential effects of partial sleep deprivation (SD) on sleep architecture and psychomotor vigilance task (PVT) performance using two different protocols (sequentially) that each restricted daily sleep to 3 hours in healthy adult men. The protocols differed only in the period of sleep restriction; in one, sleep was restricted to a 3-hour block from 12:00 AM to 3:00 AM, and in the other, sleep was restricted to a block from 3:00 AM to 6:00 AM. Subjects in the earlier sleep restriction period showed a significantly lower percentage of rapid-eye-movement (REM) sleep after 4 days (17.0 vs. 25.7 %) and a longer latency to the onset of REM sleep (L-REM) after 1 day (78.8 vs. 45.5 min) than they did in the later sleep restriction period. Reaction times on PVT performance were also better (i.e. shorter) in the earlier SR period on day 4 (249.8 vs. 272 ms). These data support the view that earlier-night sleep may be more beneficial for daytime vigilance than later-night sleep. The study also showed that cumulative declines in daytime vigilance resulted from loss of total sleep time, rather than from specific stages, and underscored the reversibility of SR effects with greater amounts of sleep.

27 citations

Journal ArticleDOI
TL;DR: Comparing the coping strategies adopted by subjects with schizotypal personality (SPD) features compared to those without SPD features, the relative effectiveness of their coping was compared, and subjects with SPD features endorsed significantly more emotion-focused strategies in uncontrollable situations.

18 citations

Journal ArticleDOI
TL;DR: The results are generally consistent with previous open-label investigations of risperidone administration in subjects with schizotaxia, and provide evidence that some neurocognitive and clinical problems are amenable to remediation in non-psychotic relatives of people with schizophrenia.

10 citations


Cited by
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Journal ArticleDOI
TL;DR: This meta-analysis is the first to provide a summary estimate of the overall effect size and investigate cross-study sources of variation in the beneficial role of coping flexibility and propose a synthesized conceptualization of cope flexibility.
Abstract: Compared with the large body of literature on coping, coping flexibility has received relatively scant research attention, although more such studies have begun to emerge recently. Researchers have conceptualized coping flexibility in diverse ways: as a broad coping repertoire, a well-balanced coping profile, cross-situational variability in strategy deployment, a good strategy-situation fit, or the perceived ability to cope with environmental changes. This meta-analysis is the first to provide a summary estimate of the overall effect size and investigate cross-study sources of variation in the beneficial role of coping flexibility. The analysis covers all available studies conducted between 1978 and 2013 that empirically tested the relationship between coping flexibility and psychological adjustment. The results of a random-effects model revealed a small to moderate overall mean effect size (r = .23, 95% CI [.19, .28], 80% CRI [-.02, .49], k = 329, N = 58,946). More important, the magnitude of the positive link between coping flexibility and psychological adjustment varied with the conceptualization of such flexibility. Studies adopting the perceived ability or strategy-situation fit conceptualization yielded moderate effect sizes, whereas those adopting the broad repertoire, balanced profile, or cross-situational variability conceptualization yielded small effect sizes. In addition, the positive link between coping flexibility and psychological adjustment was stronger in samples from countries lower (vs. higher) in individualism and samples with higher (vs. lower) average ages. Individualism and age explained 10% and 13% of the variance, respectively. We discuss the conceptual problems and implications and propose a synthesized conceptualization of coping flexibility.

382 citations

Journal ArticleDOI
TL;DR: The current meta‐analysis is the first comprehensive review to provide evidence that short‐term sleep restriction significantly impairs waking neurocognitive functioning.

258 citations

Journal ArticleDOI
01 Apr 2008
TL;DR: The challenges that abound in genetic research of schizophrenia, including issues in ascertainment, epistasis, ethnic diversity, and the potentially normalizing effects of second-generation antipsychotic medications on neurocognitive and neurophysiological measures are discussed.
Abstract: The genetics of schizophrenia has been approached utilizing a variety of methods. One emerging strategy is the use of endophenotypes in order to understand and identify the functional importance of genetically transmitted, brain-based deficits across schizophrenia kindreds. The endophenotype strategy is a topic of this issue of Schizophrenia Bulletin. Endophenotypes are quantitative, heritable, trait-related deficits typically assessed by laboratory-based methods rather than clinical observation. Endophenotypes are seen as closer to genetic variation than are clinical symptoms of schizophrenia, and are therefore closely linked to heritable risk factors. There has been a broad expansion of opportunities available to psychiatric neuroscientists who use the endophenotype strategy to understand the genetic basis of schizophrenia. In this context, genetic variation such as single nucleotide polymorphisms (SNPs) induces abnormalities in endophenotypic domains such as neurocognition, neurodevelopment, metabolism, and neurophysiology. This article discusses the challenges that abound in genetic research of schizophrenia, including issues in ascertainment, epistasis, ethnic diversity, and the potentially normalizing effects of second-generation antipsychotic medications on neurocognitive and neurophysiological measures. Robust strategies for meeting these challenges are discussed in this review and the subsequent articles in this issue. This article summarizes conceptual advances and progress in the measurement and use of endophenotypes in schizophrenia that form the basis of the multisite National Institute of Mental Health Consortium on the Genetics of Schizophrenia. The endophenotype strategy offers powerful and exciting opportunities to understand the genetically conferred neurobiological vulnerabilities and possible new strong inference and molecularly based treatments for schizophrenia.

254 citations

Journal ArticleDOI
TL;DR: This meta-analysis investigated whether the magnitude of the relationship between LOC and psychological symptoms differed among cultures with distinct individualist orientations and whether depression and anxiety symptoms yielded different patterns of cultural findings with LOC.
Abstract: Integrating more than 40 years of studies on locus of control (LOC), this meta-analysis investigated whether (a) the magnitude of the relationship between LOC and psychological symptoms differed among cultures with distinct individualist orientations and (b) depression and anxiety symptoms yielded different patterns of cultural findings with LOC. We included studies that examined global self-ratings of LOC and at least 1 of the criterion variables in nonclinical samples (age range: 18-80 years). Data were analyzed on the basis of 152 independent samples, representing the testing of 33,224 adults across 18 cultural regions. Results revealed moderately strong relationships for external LOC with depression symptoms (k = 123, N = 28,490, r = .30, 95% confidence interval [CI] [.27, .32]) and anxiety symptoms (k = 65, N = 13,208, r = .30, 95% CI [.27, .33]). Individualism explained 20% of unique variance only in the external LOC-anxiety relationship: The link between external LOC and anxiety symptoms was weaker for collectivist societies (k = 8, N = 2,297, r = .20, 95% CI [.13, .28]) compared with individualist societies (k = 54, N = 9,887, r = .32, 95% CI [.29, .34]). Such cultural differences were attributed to the reduced emphasis on agentic goals in more collectivist societies. It is noteworthy that external LOC does not carry the same negative connotations across cultures, and members of collectivist societies may be more ready to endorse such items. Culture has been examined at the country level, and the findings may not be applicable to any particular person in a cultural region. Implications for integrating cultural meaning of perceived control into formulation of theories, research design, and intervention programs are discussed.

249 citations