Bio: Xiaomin Yi is an academic researcher from Guangdong Pharmaceutical University. The author has contributed to research in topics: Solanum nigrum & Apoptosis. The author has an hindex of 13, co-authored 22 publications receiving 356 citations.
TL;DR: Harmine might be a potent inducer of apoptosis and autophagy, which offered evidences to therapy of harmine in gastric carcinoma in the folk medicine.
TL;DR: The results suggest that the steroidal saponins from berries of S. nigrum demonstrated pronounced anti-inflammatory activity and might be explored as a healthy benefit agent.
Abstract: Solanum nigrum L. or European black nightshade (Solanum genus) is a common weed of crops and gardens. The berries and leaves of S. nigrum L. are consumed as food or vegetable in some regions and reported to possess a range of biological activities. In this study, nine new steroidal saponins, solanigrosides Y1–Y9 (1–6, 10–12), together with seven known congeners, were isolated from the berries of S. nigrum. Their potential inhibitory effects on nitric oxide (NO) and IL-6 and IL-1β production induced by lipopolysaccharide (LPS) in macrophages cell line RAW 264.7 were evaluated. Compound 1 exhibited significant inhibition on NO production with an IC50 value of 9.7 μM, and some compounds exhibited significant inhibition effects on the LPS-induced IL-6 and IL-1β production. These results suggest that the steroidal saponins from berries of S. nigrum demonstrated pronounced anti-inflammatory activity and might be explored as a healthy benefit agent.
TL;DR: Seven previously undescribed steroidal glycosides, along with three known congeners, were isolated from the unripe berries of Solanum nigrum L. (Solanaceae) and their structures were elucidated on basis of 1D and 2D NMR, HR-ESI-MS spectroscopic data and GC analysis after acid hydrolysis.
TL;DR: In this article, four new phenolics (17, 18, 22 and 24) along with twenty-five known congeners were isolated and purified from the roots of hairy fig and their structures were elucidated by extensive spectroscopic analysis and chemical degradation.
TL;DR: In this paper, a phytochemical study on the extract of mango leaves resulted in the isolation and identification of 5 benzophenones and 17 flavonoids, including 4 new benzophenone glycosides, elucidated as 4′,6-dihydroxy-4-methoxybenzophenone-2-O-(2)
TL;DR: It follows that ZIF-8 is an efficient drug delivery vehicle in antitumor therapy, especially in inhibiting autophagy of cancer cells, due to its high loading ability and pH-sensitive degradation.
Abstract: High porosities, large surface areas, and tunable functionalities made metal–organic frameworks (MOFs) as effective carriers for drug delivery. One of the most promising MOFs is the zeolitic imidazolate framework (ZIF-8) crystal, an advanced functional material for small-molecule delivery, due to its high loading ability and pH-sensitive degradation. As a novel carrier, ZIF-8 nanoparticles were used in this work to control the release of an autophagy inhibitor, 3-methyladenine (3-MA), and prevent it from dissipating in a large quantity before reaching the target. The cellular uptake in HeLa cells of 3-MA encapsulated in ZIF-8 (3-MA@ZIF-8 NPs) is facilitated through the nanoparticle internalization with reference to TEM observations and the quantitative analyses of zinc by ICP-MS. The autophagy-related proteins and autophagy flux in HeLa cells treated with 3-MA@ZIF-8 NPs show that the autophagosome formation is significantly blocked, which reveals that the pH-sensitive dissociation increases the efficiency...
TL;DR: This review focused on the role of this pathway in gastric cancer development, prognosis, and metastasis, with an emphasis on epigenetic alterations including DNA methylation, histone modifications, and post-transcriptional modulations through non-coding RNAs fluctuations as well as H. pylori and Epstein-Barr virus infections.
TL;DR: The extensive lethal effect of AgNPs against clinically important pathogens demonstrated that the mango flower mediated AgNPS could be applied as potential antibacterial agent to control the bacterial population in the respective industries.
TL;DR: This review focuses on the anticancer properties of several typical naturally derived triterpenoids and saikosaponins and steroid saponins isolated from Chinese medicines.
Abstract: Saponins are glycosides with triterpenoid or spirostane aglycones that demonstrate various pharmacological effects against mammalian diseases. To promote the research and development of anticancer agents from saponins, this review focuses on the anticancer properties of several typical naturally derived triterpenoid saponins (ginsenosides and saikosaponins) and steroid saponins (dioscin, polyphyllin, and timosaponin) isolated from Chinese medicines. These saponins exhibit in vitro and in vivo anticancer effects, such as anti-proliferation, anti-metastasis, anti-angiogenesis, anti-multidrug resistance, and autophagy regulation actions. In addition, related signaling pathways and target proteins involved in the anticancer effects of saponins are also summarized in this work.
01 Jan 2006
TL;DR: It is demonstrated that the lipid-soluble extract of S. nigrum leaves possessed antinociceptive, anti-inflammatory and anti-pyretic properties and confirmed the traditional claims.
Abstract: Department of Biomedical Sciences, Faculty of Medicineand Health Sciences, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia(Received May 31, 2006; Accepted August 11, 2006)AIM: The present study was carried out to evaluate the antinociceptive, anti-in‰ammatory and antipyretic eSects ofchloroform extract of Solanum nigrum leaves using various animal models. METHODS: The extract was prepared bysoaking(1：20; w/v) the air-dried powdered leaves(20 g) in chloroform for 72 hrs followed by evaporation(40°C) un-der reduced pressure to dryness (1.26 g) andthendissolved(1：50; w/v) in dimethylsulfoxide (DMSO). The super-natant, considered as the stock solution with dose of 200 mg/kg, was diluted using DMSO to 20 and 100 mg/kg, and alldoses were administered(s.c.; 10 ml/kg) in mice/rats 30 min prior to tests. RESULTS: The extract exhibited signiˆcant(p＜0.05) antinociceptive activity when assessed using the abdominal constriction, hot plate and formalin tests. The ex-tract also produced signiˆcant (p＜0.05) anti-in‰ammatory and antipyretic activities when assessed using the car-rageenan-induced paw edema and brewer's yeast-induced pyrexia tests. Overall, the activities occurred in a dose-in-dependent manner. CONCLUSION: The present study demonstrated that the lipid-soluble extract ofS. nigrumleavespossessed antinociceptive, anti-in‰ammatory and anti-pyretic properties and conˆrmed the traditional claims.Key words―Solanum nigrum; chloroform extract; antinociceptive; anti-in‰ammatory; antipyretic