Author
Xiaoni Xie
Bio: Xiaoni Xie is an academic researcher from China Pharmaceutical University. The author has contributed to research in topics: Ginsenoside & Antibacterial activity. The author has an hindex of 2, co-authored 2 publications receiving 41 citations.
Topics: Ginsenoside, Antibacterial activity
Papers
More filters
TL;DR: A novel class of ocotillol-type triterpenoid derivatives have been synthesized and evaluated for their in-vitro antibacterial activity against several representative pathogenic bacterial strains.
36 citations
Patent•
16 Jan 2013
TL;DR: In this article, the (20S,24S)-ocotillol ginsenoside derivatives were disclosed as general formula (I) and a preparation method of the ( 20S, 24S) ginsenoide derivatives was described.
Abstract: The invention relates to the fields of organic synthesis and pharmacochemistry, particularly (20S,24S)-ocotillol ginsenoside derivatives, of which the structure is disclosed as general formula (I). The invention also discloses a preparation method of the (20S,24S)-ocotillol ginsenoside derivatives, a pharmaceutical composition containing the (20S,24S)-ocotillol ginsenoside derivatives, and application of the (20S,24S)-ocotillol ginsenoside derivatives in bacterial infection disease inhibition. General formula (I).
8 citations
Cited by
More filters
TL;DR: This review sums up the discovery, semisynthesis, biological activities, and metabolism of ocotillol-type saponins.
60 citations
TL;DR: Mutation of this residue results in a major change in triterpene cyclization, with production of tetracyclic rather than pentacyclics products, and further open up opportunities to engineer novel oxygenated triterPene scaffolds by manipulating the precursor supply.
Abstract: Triterpenes are structurally complex plant natural products with numerous medicinal applications. They are synthesized through an origami-like process that involves cyclization of the linear 30 carbon precursor 2,3-oxidosqualene into different triterpene scaffolds. Here, through a forward genetic screen in planta, we identify a conserved amino acid residue that determines product specificity in triterpene synthases from diverse plant species. Mutation of this residue results in a major change in triterpene cyclization, with production of tetracyclic rather than pentacyclic products. The mutated enzymes also use the more highly oxygenated substrate dioxidosqualene in preference to 2,3-oxidosqualene when expressed in yeast. Our discoveries provide new insights into triterpene cyclization, revealing hidden functional diversity within triterpene synthases. They further open up opportunities to engineer novel oxygenated triterpene scaffolds by manipulating the precursor supply.
47 citations
TL;DR: The aim of this paper is to review the activity of pentacyclic triterpenoids belonging to the ursane, oleanane, or lupane groups against Staphylococcus aureus and summarize their activity as anti-staphylitiscal compounds but also as resistance modifying agents when combined with common antibiotics.
Abstract: Staphylococcus aureus infections are considered as seriously problematic for human health and necessitate the development of new medicines and innovative antimicrobial strategies. Plant secondary metabolites have already demonstrated their potential as antibacterials when used alone but also in combination with other antimicrobial agents to potentiate their activity. Triterpenoids are widely distributed in the plant kingdom and known to have many beneficial effects, including anti-inflammatory, immunomodulatory, anti-proliferative, antimycotic, or antimicrobial activity. The aim of this paper is to review the activity of pentacyclic triterpenoids belonging to the ursane, oleanane, or lupane groups against Staphylococcus aureus. We summarize their activity as anti-staphylococcal compounds but also as resistance modifying agents when combined with common antibiotics.
44 citations
TL;DR: It is concluded that ORA reverseABCB1-mediated MDR by competitively inhibiting the ABCB1 drug efflux function by reverse the resistance to paclitaxel and vincristine in ABCB 1-overexpressing SW620/Ad300 and HEK/ABCB 1 cells.
Abstract: Overexpression of ATP-Binding Cassette transporters leads to multidrug resistance in cancer cells and results in the failure of chemotherapy. In this in-vitro study, we investigated whether or not (20S, 24R/S)-epoxy-12β, 25-dihydroxy-dommarane-3β-amine (ORA and OSA), a pair of semi-synthetic ocotillol analogue epimers, could inhibit the ABCB1 transporter. ORA (1 μM and 3 μM) significantly reversed the resistance to paclitaxel and vincristine in ABCB1-overexpressing SW620/Ad300 and HEK/ABCB1 cells, whereas OSA had no significant effects. In addition, ORA (3 μM) significantly increased the intracellular accumulation of [3H]-paclitaxel by suppressing the efflux function of ABCB1. Meanwhile, both ORA (3 μM) and OSA (3 μM) did not significantly alter the expression level or the subcellular location of ABCB1 protein. Moreover, the ABCB1 ATPase study suggested that ORA had a stronger stimulatory effect on the ATPase activity than OSA. ORA also exhibited a higher docking score as compared with OSA inside transmembrane domain of ABCB1. Overall, we concluded that ORA reverse ABCB1-mediated MDR by competitively inhibiting the ABCB1 drug efflux function.
39 citations
TL;DR: The results demonstrate that nitrated substitutions at C-3 of ocotillol-type derivatives could provide an approach to expand their antibacterial spectrum, and that ocotilla-type triterpenoids may also be developed as appropriate carriers for NO donors in antibacterial agent discovery with low cytotoxicity.
32 citations