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Xiaoping Li
Researcher at University of Copenhagen
Publications - 23
Citations - 7552
Xiaoping Li is an academic researcher from University of Copenhagen. The author has contributed to research in topics: Gut flora & Microbiome. The author has an hindex of 10, co-authored 22 publications receiving 5634 citations. Previous affiliations of Xiaoping Li include Beijing Genomics Institute.
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Journal ArticleDOI
A metagenome-wide association study of gut microbiota in type 2 diabetes
Junjie Qin,Yingrui Li,Zhiming Cai,Shenghui Li,Jianfeng Zhu,Fan Zhang,Suisha Liang,Wenwei Zhang,Yuanlin Guan,Dongqian Shen,Yangqing Peng,Dongya Zhang,Zhuye Jie,Wenxian Wu,Youwen Qin,Wenbin Xue,Junhua Li,Lingchuan Han,Donghui Lu,Peixian Wu,Yali Dai,Xiaojuan Sun,Zesong Li,Aifa Tang,Shilong Zhong,Xiaoping Li,Weineng Chen,Ran Xu,Mingbang Wang,Qiang Feng,Meihua Gong,Jing Yu,Yanyan Zhang,Ming Zhang,Torben Hansen,Gaston Sanchez,Jeroen Raes,Gwen Falony,Shujiro Okuda,Mathieu Almeida,Emmanuelle Le-chatelier,Pierre Renault,Nicolas Pons,Jean-Michel Batto,Zhaoxi Zhang,Hua Chen,Ruifu Yang,Wei-Mou Zheng,Songgang Li,Huanming Yang,Jian Wang,S. Dusko Ehrlich,Rasmus Nielsen,Oluf Pedersen,Oluf Pedersen,Karsten Kristiansen,Jun Wang +56 more
TL;DR: MGWAS analysis showed that patients with type 2 diabetes were characterized by a moderate degree of gut microbial dysbiosis, a decrease in the abundance of some universal butyrate-producing bacteria and an increase in various opportunistic pathogens, as well as an enrichment of other microbial functions conferring sulphate reduction and oxidative stress resistance.
Journal ArticleDOI
The gut microbiome in atherosclerotic cardiovascular disease
Zhuye Jie,Huihua Xia,Shilong Zhong,Shilong Zhong,Qiang Feng,Shenghui Li,Suisha Liang,Huanzi Zhong,Zhipeng Liu,Yuan Gao,Hui Zhao,Dongya Zhang,Zheng Su,Zhiwei Fang,Zhou Lan,Junhua Li,Liang Xiao,Jun Li,Ruijun Li,Xiaoping Li,Fei Li,Huahui Ren,Yan Huang,Yangqing Peng,Guanglei Li,Bo Wen,Bo Dong,Jiyan Chen,Qing-Shan Geng,Zhi-Wei Zhang,Huanming Yang,Jian Wang,Jun Wang,Xuan Zhang,Lise Madsen,Susanne Brix,Guang Ning,Xun Xu,Xin Liu,Yong Hou,Huijue Jia,Kunlun He,Karsten Kristiansen +42 more
TL;DR: A metagenome-wide association study on stools from individuals with atherosclerotic cardiovascular disease and healthy controls is performed, identifying microbial strains and functions associated with the disease.
Journal ArticleDOI
Gut microbiome development along the colorectal adenoma-carcinoma sequence.
Qiang Feng,Suisha Liang,Huijue Jia,Andreas Stadlmayr,Longqing Tang,Zhou Lan,Dongya Zhang,Huihua Xia,Xiaoying Xu,Zhuye Jie,Lili Su,Xiaoping Li,Xin Li,Junhua Li,Liang Xiao,Ursula Huber-Schönauer,David Niederseer,Xun Xu,Jumana Y. Al-Aama,Huanming Yang,Jian Wang,Karsten Kristiansen,Manimozhiyan Arumugam,Herbert Tilg,Christian Datz,Jun Wang +25 more
TL;DR: It is suggested that faecal microbiome-based strategies may be useful for early diagnosis and treatment of colorectal adenoma or carcinoma and high intake of red meat relative to fruits and vegetables appears to associate with outgrowth of bacteria that might contribute to a more hostile gut environment.
Journal ArticleDOI
A catalog of the mouse gut metagenome
Liang Xiao,Qiang Feng,Suisha Liang,Si Brask Sonne,Zhongkui Xia,Xinmin Qiu,Xiaoping Li,Hua Long,Jianfeng Zhang,Dongya Zhang,Liu Chuan,Zhiwei Fang,Joyce Chou,Jacob Glanville,Qin Hao,Dorota Ewa Kotowska,Camilla Colding,Tine Rask Licht,Donghai Wu,Jun Yu,Joseph J.Y. Sung,Qiaoyi Liang,Junhua Li,Huijue Jia,Zhou Lan,Valentina Tremaroli,Piotr Dworzynski,H. Bjørn Nielsen,Fredrik Bäckhed,Joël Doré,S. Dusko Ehrlich,John C. Lin,Manimozhiyan Arumugam,Jun Wang,Lise Madsen,Karsten Kristiansen +35 more
TL;DR: A catalog of the mouse gut metagenome comprising ∼2.6 million nonredundant genes by sequencing DNA from fecal samples of 184 mice is established, finding a core set of 26 metagenomic species found in 95% of the mice.
Journal ArticleDOI
High-fat feeding rather than obesity drives taxonomical and functional changes in the gut microbiota in mice.
Liang Xiao,Si Brask Sonne,Qiang Feng,Ning Chen,Zhongkui Xia,Xiaoping Li,Zhiwei Fang,Dongya Zhang,Even Fjære,Even Fjære,Lisa Kolden Midtbø,Lisa Kolden Midtbø,Muriel Derrien,Floor Hugenholtz,Longqing Tang,Junhua Li,Jianfeng Zhang,Liu Chuan,Qin Hao,Ulla Vogel,Alicja Mortensen,Michiel Kleerebezem,Tine Rask Licht,Huanming Yang,Jian Wang,Yingrui Li,Manimozhiyan Arumugam,Jun Wang,Lise Madsen,Lise Madsen,Karsten Kristiansen +30 more
TL;DR: Differences in the abundance of butyrate and propionate producing bacteria in the gut may at least in part contribute to the observed differences in obesity propensity in Sv129 and BL6 mice.