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Author

Xiaoshan Liu

Other affiliations: Guangdong Medical College
Bio: Xiaoshan Liu is an academic researcher from Seoul National University. The author has contributed to research in topics: Medicine & Genotoxicity. The author has an hindex of 11, co-authored 16 publications receiving 932 citations. Previous affiliations of Xiaoshan Liu include Guangdong Medical College.

Papers
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TL;DR: The results of this study showed that OPFRs could alter sex hormone balance through several mechanisms including alterations of steroidogenesis or estrogen metabolism.

345 citations

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TL;DR: Overall, the observation indicates that both TDCPP and TPP could disturb the sex hormone balance by altering regulatory mechanisms of the HPG axis, eventually leading to disruption of reproductive performance in fish.

231 citations

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TL;DR: The results demonstrated that ibuprofen could modulate hormone production and related gene transcription of the HPG axis in a sex-dependent way, which could cause adverse effects on reproduction and the development of offspring.

137 citations

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TL;DR: Results clearly show several alternative bisphenols can cause genotoxicity that could be rescued by homologous recombination pathway, and some bispenols induced even greater genotoxic potentials than that of BPA.

93 citations

Journal ArticleDOI
TL;DR: Observations show that TDCPP and TPP exposure can lead to sex-dependent disruptions of thyroid hormone balances in the adult zebrafish through alterations of the hypothalamus-pituitary-thyroid (HPT) axis.

88 citations


Cited by
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Journal ArticleDOI
TL;DR: The removal of bisphenol A (BPA) from consumer products, often label labeled as an endocrine-disrupting chemical, has been discussed in this paper.
Abstract: BackgroundIncreasing concern over bisphenol A (BPA) as an endocrine-disrupting chemical and its possible effects on human health have prompted the removal of BPA from consumer products, often label...

977 citations

Journal ArticleDOI
TL;DR: In this paper, a review of the current state of knowledge on the occurrence of bisphenol analogues (other than BPA) in the environment, consumer products and foodstuffs, human exposure and biomonitoring, and toxicity.
Abstract: Numerous studies have investigated the environmental occurrence, human exposure, and toxicity of bisphenol A (BPA). Following stringent regulations on the production and usage of BPA, several bisphenol analogues have been produced as a replacement for BPA in various applications. The present review outlines the current state of knowledge on the occurrence of bisphenol analogues (other than BPA) in the environment, consumer products and foodstuffs, human exposure and biomonitoring, and toxicity. Whereas BPA was still the major bisphenol analogue found in most environmental monitoring studies, BPF and BPS were also frequently detected. Elevated concentrations of BPAF, BPF, and BPS (i.e., similar to or greater than that of BPA) have been reported in the abiotic environment and human urine from some regions. Many analogues exhibit endocrine disrupting effects, cytotoxicity, genotoxicity, reproductive toxicity, dioxin-like effects, and neurotoxicity in laboratory studies. BPAF, BPB, BPF, and BPS have been show...

968 citations

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TL;DR: Biotransformation of BPA in animals, plants and microorganisms, resulting in the formation of various metabolites that exhibit different from BPA toxicity will be described.

718 citations

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TL;DR: The utility of coordinating global sensing of environmental contaminants efforts through integration of environmental monitoring and specimen banking to identify regions for implementation of more robust environmental assessment and management programs is highlighted.
Abstract: Because bisphenol A (BPA) is a high production volume chemical, we examined over 500 peer-reviewed studies to understand its global distribution in effluent discharges, surface waters, sewage sludge, biosolids, sediments, soils, air, wildlife, and humans. Bisphenol A was largely reported from urban ecosystems in Asia, Europe, and North America; unfortunately, information was lacking from large geographic areas, megacities, and developing countries. When sufficient data were available, probabilistic hazard assessments were performed to understand global environmental quality concerns. Exceedances of Canadian Predicted No Effect Concentrations for aquatic life were >50% for effluents in Asia, Europe, and North America but as high as 80% for surface water reports from Asia. Similarly, maximum concentrations of BPA in sediments from Asia were higher than Europe. Concentrations of BPA in wildlife, mostly for fish, ranged from 0.2 to 13 000 ng/g. We observed 60% and 40% exceedences of median levels by the US Centers for Disease Control and Prevention's National Health and Nutrition Examination Survey in Europe and Asia, respectively. These findings highlight the utility of coordinating global sensing of environmental contaminants efforts through integration of environmental monitoring and specimen banking to identify regions for implementation of more robust environmental assessment and management programs.

508 citations

Journal ArticleDOI
TL;DR: The diverse absorption routes of OPFRs by animals and humans (e.g., inhalation, ingestion, dermal absorption and gill absorption) are reviewed and bioaccumulation and biomagnification potentials in different types of organisms and food webs are summarized.

348 citations