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Xiaoyi Zhang

Bio: Xiaoyi Zhang is an academic researcher from Wuhan University. The author has contributed to research in topics: Medicine & Acute pancreatitis. The author has an hindex of 6, co-authored 7 publications receiving 343 citations.

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Journal ArticleDOI
TL;DR: COVID-19 patients with diabetes had worse outcomes compared with the sex- and age-matched patients without diabetes, and older age and comorbid hypertension independently contributed to in-hospital death of patients with Diabetes.
Abstract: OBJECTIVE Diabetes is common in COVID-19 patients and associated with unfavorable outcomes. We aimed to describe the characteristics and outcomes and to analyze the risk factors for in-hospital mortality of COVID-19 patients with diabetes. RESEARCH DESIGN AND METHODS This two-center retrospective study was performed at two tertiary hospitals in Wuhan, China. Confirmed COVID-19 patients with diabetes (N = 153) who were discharged or died from 1 January 2020 to 8 March 2020 were identified. One sex- and age-matched COVID-19 patient without diabetes was randomly selected for each patient with diabetes. Demographic, clinical, and laboratory data were abstracted. Cox proportional hazards regression analyses were performed to identify the risk factors associated with the mortality in these patients. RESULTS Of 1,561 COVID-19 patients, 153 (9.8%) had diabetes, with a median age of 64.0 (interquartile range 56.0–72.0) years. A higher proportion of intensive care unit admission (17.6% vs. 7.8%, P = 0.01) and more fatal cases (20.3% vs. 10.5%, P = 0.017) were identified in COVID-19 patients with diabetes than in the matched patients. Multivariable Cox regression analyses of these 306 patients showed that hypertension (hazard ratio [HR] 2.50, 95% CI 1.30–4.78), cardiovascular disease (HR 2.24, 95% CI 1.19–4.23), and chronic pulmonary disease (HR 2.51, 95% CI 1.07–5.90) were independently associated with in-hospital death. Diabetes (HR 1.58, 95% CI 0.84–2.99) was not statistically significantly associated with in-hospital death after adjustment. Among patients with diabetes, nonsurvivors were older (76.0 vs. 63.0 years), most were male (71.0% vs. 29.0%), and were more likely to have underlying hypertension (83.9% vs. 50.0%) and cardiovascular disease (45.2% vs. 14.8%) (all P values CONCLUSIONS COVID-19 patients with diabetes had worse outcomes compared with the sex- and age-matched patients without diabetes. Older age and comorbid hypertension independently contributed to in-hospital death of patients with diabetes.

281 citations

Journal ArticleDOI
Minming Li1, Zong-Suo Zhang1, Xiaoyi Zhang1, Kun Li1, Xue-Feng Yu1 
TL;DR: Strong local field in the Au/Ag nanoshuttles enhanced by longitudinal surface plasmon resonance (LSPR) were investigated by theoretical calculations and experimental measurements.
Abstract: Au/Ag nanoshuttles with sharp tips at both ends have been synthesized in glycine solution by chemically depositing silver on gold nanorods. Strong local field in the Au/Ag nanoshuttles enhanced by longitudinal surface plasmon resonance (LSPR) were investigated by theoretical calculations and experimental measurements. At the corresponding LSPR wavelengths, the extinction cross section and nonlinear refraction of the Au/Ag nanoshuttles are about 1.5 and 8.0 times of those of the original Au nanorods, respectively.

60 citations

Posted ContentDOI
13 Mar 2020-medRxiv
TL;DR: Older patients (>70 years) with comorbidities had a steeply increased risk of death with COVID-19 and Elevated high sensitivity troponin, neutrophils and depressed oxygen saturation predicted the rapid death of patients.
Abstract: Rationale COVID-19 have deprived many lives in Wuhan, China and caused global concerns. Few studies focused on clinical characteristics non-survivors hospitalized with COVID-19. Objectives We aimed to clarify the clinical characteristics of died patients with COVID-19 and tracked the causes of the rapid disease progression and death. Methods 101 non-surviving patients with confirmed COVID-19 were included in this retrospective study. Clinical data were collected and compared between non-survivors who died within 3 days and after 3 days of admission. Multivariable regression analysis was used to analyze risk factors associated with rapid disease progression and death. Measurements and Main Results Among included patients, median age was 71 years (IQR, 59-80), 60 (59.41%) were men. 82 (81.19%) had one or more comorbidities including hypertension (59 [58.42%]), diabetes (22 [21.78%]) etc. 100 (99.01%) suffered respiratory failure, 53 (52.48%) developed acute cardiac injury, acute kidney and liver injury occurred in 23 (22.77%) and 18 (17.82%) patients, respectively. Multivariable regression analysis showed that elevated high sensitivity troponin I (OR 2.68, 95%CI 1.31-5.49, P=0.007), neutrophils (OR 1.14, 95%CI 1.01-1.28, P=0.033) and depressed oxygen saturation (OR 0.94, 95%CI 0.89-0.99, P=0.027) on admission were associated with rapid death of patients with COVID-19. Conclusions Older patients (>70 years) with comorbidities had a steeply increased risk of death with COVID-19. Respiratory failure, acute cardiac and kidney injury played a crucial role in the death of patients. Elevated high sensitivity troponin, neutrophils and depressed oxygen saturation predicted the rapid death of patients. At a Glance Commentary Scientific Knowledge on the Subject COVID-19 have deprived many lives and caused global concerns. We searched PubMed for articles published up to Mar 10, 2020, using the keywords “2019 novel coronavirus”, “2019-nCoV”, “COVID-19”, or “SARS-CoV-2”. We identified that few studies focused on clinical characteristics of non-survivors with COVID-19. What This Study Adds to the Field We reported the demographic and clinical characteristics of 101 non-surviving hospitalized patients with COVID-19. This study showed that older patients (>70 years) with comorbidities had a steeply increased risk of death when they suffered COVID-19. Besides, respiratory failure, acute cardiac and kidney injury played a crucial role in the rapid death of patients. Furthermore, multivariable regression analysis revealed elevated levels of high sensitivity troponin I, neutrophils and depressed oxygen saturation were associated with increased odds of rapid death of patients with COVID-19.

46 citations

Journal ArticleDOI
TL;DR: It is demonstrated that TRAF1 is a crucial early mediator of hepatic I/R injury and suggests that TRAf1 may be a potential gene therapy target for the treatment of liver injury.
Abstract: Tumor necrosis factor receptor-associated factor 1 (TRAF1), an adapter in signal transduction, is involved in immunity and in apoptotic processes in various cell types. However, little is known about its function and the molecular mechanism of its activation during liver injury. This study tested the hypothesis that TRAF1 is a mediator of cell injury after hepatic ischemia/reperfusion injury (I/R). In a mouse hepatic I/R injury model, we found that TRAF1 expression was highly induced. TRAF1 deficiency was liver protective, whereas sustained TRAF1 overexpression aggravated liver injury in response to hepatic I/R injury. Mechanistic studies demonstrated that a deficiency of TRAF1 in cultured hepatocytes led to the inhibition of NF-κB-mediated inflammatory responses, suppression of the ASK/JNK pro-death pathway and promotion of cellular regeneration capacity. In contrast, the converse occurred in hepatocyte-specific TRAF1 transgenic mice. TRAF1 activated the ASK1/JNK pathway and promoted hepatic injury. Our study demonstrates that TRAF1 is a crucial early mediator of hepatic I/R injury and suggests that TRAF1 may be a potential gene therapy target for the treatment of liver injury.

34 citations

Journal ArticleDOI
TL;DR: Serum CysC level at ICU admission was an important biomarker for predicting AKI and 28-day mortality, and significant risk factors of stroke-associated AKI were identified among stroke patients in ICU.
Abstract: Objective: We investigated the epidemiology, risk factors, and predictive parameters for ischemic or hemorrhagic stroke-associated acute kidney injury (AKI) and mortality in a general intensive care unit (ICU) in China. Methods: During 5 years, 479 stroke patients were screened, and 381 were enrolled. AKI was diagnosed within 7 days after ICU admission, based on the Kidney Disease Improving Global Outcomes criteria. Risk factors of AKI were assessed by Logistic regression analyses, and the predictive biomarkers for AKI were determined using receiver operating characteristic (ROC) curves. Also examined were factors influencing 28-day mortality, using Cox regression analyses and Kaplan-Meier curves. ­Results: Among all, 115 (30.18%) patients developed AKI. Multivariate regression analyses revealed that the following features at ICU admission significantly increased the risk of developing AKI: an increased National Institutes of Health Stroke Scale score (OR 1.136, p < 0.001) and Acute Physiology and Chronic Health Evaluation II score (OR 1.107, p = 0.042); hypertension (OR 2.346, p = 0.008); use of loop diuretics (OR 1.961, p = 0.032); and higher serum cystatin C (sCysC; OR 8.156, p = 0.001). The area under the ROC curves for predicting AKI using sCysC was 0.772, slightly better than that of other biomarkers. The sCysC ≥0.93 mg/L (hazard ratio 1.844, p = 0.004) significantly predicted 28-day mortality. Conclusions: Among stroke patients in ICU, we identified significant risk factors of stroke-associated AKI. Serum CysC level at ICU admission was an important biomarker for predicting AKI and 28-day mortality.

17 citations


Cited by
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01 Mar 2007
TL;DR: An initiative to develop uniform standards for defining and classifying AKI and to establish a forum for multidisciplinary interaction to improve care for patients with or at risk for AKI is described.
Abstract: Acute kidney injury (AKI) is a complex disorder for which currently there is no accepted definition. Having a uniform standard for diagnosing and classifying AKI would enhance our ability to manage these patients. Future clinical and translational research in AKI will require collaborative networks of investigators drawn from various disciplines, dissemination of information via multidisciplinary joint conferences and publications, and improved translation of knowledge from pre-clinical research. We describe an initiative to develop uniform standards for defining and classifying AKI and to establish a forum for multidisciplinary interaction to improve care for patients with or at risk for AKI. Members representing key societies in critical care and nephrology along with additional experts in adult and pediatric AKI participated in a two day conference in Amsterdam, The Netherlands, in September 2005 and were assigned to one of three workgroups. Each group's discussions formed the basis for draft recommendations that were later refined and improved during discussion with the larger group. Dissenting opinions were also noted. The final draft recommendations were circulated to all participants and subsequently agreed upon as the consensus recommendations for this report. Participating societies endorsed the recommendations and agreed to help disseminate the results. The term AKI is proposed to represent the entire spectrum of acute renal failure. Diagnostic criteria for AKI are proposed based on acute alterations in serum creatinine or urine output. A staging system for AKI which reflects quantitative changes in serum creatinine and urine output has been developed. We describe the formation of a multidisciplinary collaborative network focused on AKI. We have proposed uniform standards for diagnosing and classifying AKI which will need to be validated in future studies. The Acute Kidney Injury Network offers a mechanism for proceeding with efforts to improve patient outcomes.

5,467 citations

01 Jan 2020
TL;DR: Prolonged viral shedding provides the rationale for a strategy of isolation of infected patients and optimal antiviral interventions in the future.
Abstract: Summary Background Since December, 2019, Wuhan, China, has experienced an outbreak of coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Epidemiological and clinical characteristics of patients with COVID-19 have been reported but risk factors for mortality and a detailed clinical course of illness, including viral shedding, have not been well described. Methods In this retrospective, multicentre cohort study, we included all adult inpatients (≥18 years old) with laboratory-confirmed COVID-19 from Jinyintan Hospital and Wuhan Pulmonary Hospital (Wuhan, China) who had been discharged or had died by Jan 31, 2020. Demographic, clinical, treatment, and laboratory data, including serial samples for viral RNA detection, were extracted from electronic medical records and compared between survivors and non-survivors. We used univariable and multivariable logistic regression methods to explore the risk factors associated with in-hospital death. Findings 191 patients (135 from Jinyintan Hospital and 56 from Wuhan Pulmonary Hospital) were included in this study, of whom 137 were discharged and 54 died in hospital. 91 (48%) patients had a comorbidity, with hypertension being the most common (58 [30%] patients), followed by diabetes (36 [19%] patients) and coronary heart disease (15 [8%] patients). Multivariable regression showed increasing odds of in-hospital death associated with older age (odds ratio 1·10, 95% CI 1·03–1·17, per year increase; p=0·0043), higher Sequential Organ Failure Assessment (SOFA) score (5·65, 2·61–12·23; p Interpretation The potential risk factors of older age, high SOFA score, and d-dimer greater than 1 μg/mL could help clinicians to identify patients with poor prognosis at an early stage. Prolonged viral shedding provides the rationale for a strategy of isolation of infected patients and optimal antiviral interventions in the future. Funding Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences; National Science Grant for Distinguished Young Scholars; National Key Research and Development Program of China; The Beijing Science and Technology Project; and Major Projects of National Science and Technology on New Drug Creation and Development.

4,408 citations

Journal ArticleDOI
TL;DR: This review presents a comprehensive overview of the flourishing field of Au nanorods in the past five years, focusing mainly on the approaches for the growth, shape and size tuning, functionalization, and assembly of Au Nanorods, as well as the methods for the preparation of their hybrid structures.
Abstract: Gold nanorods have been receiving extensive attention owing to their extremely attractive applications in biomedical technologies, plasmon-enhanced spectroscopies, and optical and optoelectronic devices. The growth methods and plasmonic properties of Au nanorods have therefore been intensively studied. In this review, we present a comprehensive overview of the flourishing field of Au nanorods in the past five years. We will focus mainly on the approaches for the growth, shape and size tuning, functionalization, and assembly of Au nanorods, as well as the methods for the preparation of their hybrid structures. The plasmonic properties and the associated applications of Au nanorods will also be discussed in detail.

1,494 citations

Journal ArticleDOI
TL;DR: This Review highlights morphology-dependent properties of nonspherical noble metal nanoparticles with a focus on localized surface plasmon resonance and local field enhancement, as well as their applications in various fields including Raman spectroscopy, fluorescence enhancement, analytics and sensing, photothermal therapy, (bio-)diagnostics, and imaging.
Abstract: Nanoparticles of noble metals belong to the most extensively studied colloidal systems in the field of nanoscience and nanotechnology. Due to continuing progress in the synthesis of nanoparticles with controlled morphologies, the exploration of unique morphology-dependent properties has gained momentum. Anisotropic features in nonspherical nanoparticles make them ideal candidates for enhanced chemical, catalytic, and local field related applications. Nonspherical plasmon resonant nanoparticles offer favorable properties for their use as analytical tools, or as diagnostic and therapeutic agents. This Review highlights morphology-dependent properties of nonspherical noble metal nanoparticles with a focus on localized surface plasmon resonance and local field enhancement, as well as their applications in various fields including Raman spectroscopy, fluorescence enhancement, analytics and sensing, photothermal therapy, (bio-)diagnostics, and imaging.

922 citations

Journal ArticleDOI
TL;DR: This article reviews the recent progress in the colloid-chemical synthesis of nonspherical nanoparticles of a few important noble metals, highlighting the factors that influence the particle morphology and discussing the mechanisms behind the nonsphericals shape evolution.
Abstract: Metal nanoparticles have been the subject of widespread research over the past two decades. In recent years, noble metals have been the focus of numerous studies involving synthesis, characterization, and applications. Synthesis of an impressive range of noble metal nanoparticles with varied morphologies has been reported. Researchers have made a great progress in learning how to engineer materials on a nanometer length scale that has led to the understanding of the fundamental size- and shape-dependent properties of matter and to devising of new applications. In this article, we review the recent progress in the colloid-chemical synthesis of nonspherical nanoparticles of a few important noble metals (mainly Ag, Au, Pd, and Pt), highlighting the factors that influence the particle morphology and discussing the mechanisms behind the nonspherical shape evolution. The article attempts to present a thorough discussion of the basic principles as well as state-of-the-art morphology control in noble metal nanoparticles.

820 citations