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Xiaoyuan Chen
Researcher at National University of Singapore
Publications - 1270
Citations - 115993
Xiaoyuan Chen is an academic researcher from National University of Singapore. The author has contributed to research in topics: Photothermal therapy & Medicine. The author has an hindex of 149, co-authored 994 publications receiving 89870 citations. Previous affiliations of Xiaoyuan Chen include Brown University & University of Southern California.
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Evaluation of synovial angiogenesis in patients with rheumatoid arthritis using ⁶⁸Ga-PRGD2 PET/CT: a prospective proof-of-concept cohort study.
TL;DR: This is the first integrin imaging study conducted in patients with RA that preliminarily indicates the effectiveness of the novel method for evaluating synovial angiogenesis, and 68Ga-PRGD2 specifically accumulated in the synovia with active inflammation rich in neovasculature with high-level αvβ3-integrin expression.
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In vivo optical imaging of membrane-type matrix metalloproteinase (MT-MMP) activity.
TL;DR: It is demonstrated for the first time that a fluorogenic probe can be used as an in vivo imaging agent for visualizing activities of membrane-tethered, membrane-type matrix metalloproteinases (MT-MMPs) and can be widely applied to designing probes and to applications targeting various membrane-anchored proteases in vivo.
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Versatile Octapod-Shaped Hollow Porous Manganese(II) Oxide Nanoplatform for Real-Time Visualization of Cargo Delivery.
Ruixue Wei,Xuanqing Gong,Hongyu Lin,Ke Zhang,Ao Li,Kun Liu,Hong Shan,Xiaoyuan Chen,Jinhao Gao +8 more
TL;DR: This octapod-shaped Cargo@HPMO can act as a smart and versatile nanoplatform with pH-responsive multimodal imaging and site-specific drug delivery for the development of accurate diagnosis and effective therapy for cancer.
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Evaluation of 64Cu Labeled GX1: A Phage Display Peptide Probe for PET Imaging of Tumor Vasculature
Kai Chen,Kai Chen,Xilin Sun,Gang Niu,Ying Ma,Li-Peng Yap,Xiaoli Hui,Kaichun Wu,Daiming Fan,Peter S. Conti,Xiaoyuan Chen +10 more
TL;DR: In this paper, a 64Cu-labeled GX1 peptide was evaluated as a potential radiotracer for microPET imaging of tumor vasculature in a U87MG tumor xenografted mouse model.
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PEG-transferrin conjugated TRAIL (TNF-related apoptosis-inducing ligand) for therapeutic tumor targeting
Tae Hyung Kim,Young Gi Jo,Hai Hua Jiang,Sung Mook Lim,Yu Seok Youn,Seulki Lee,Xiaoyuan Chen,Youngro Byun,Kang Choon Lee +8 more
TL;DR: Results suggest that Tf-PEG(10K)-TRAIL is a superior pharmacokinetic conjugate that potently targets tumors and that it should be viewed as a potential cancer therapy.