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Xiaoyuan Chen
Researcher at National University of Singapore
Publications - 1270
Citations - 115993
Xiaoyuan Chen is an academic researcher from National University of Singapore. The author has contributed to research in topics: Photothermal therapy & Medicine. The author has an hindex of 149, co-authored 994 publications receiving 89870 citations. Previous affiliations of Xiaoyuan Chen include Brown University & University of Southern California.
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Journal ArticleDOI
Polymeric Nanovehicle Regulated Spatiotemporal Real-Time Imaging of the Differentiation Dynamics of Transplanted Neural Stem Cells after Traumatic Brain Injury
Zhe Wang,Yu Wang,Zhiyong Wang,Jun Zhao,J. Silvio Gutkind,Avinash Srivatsan,Guofeng Zhang,Hsien-Shun Liao,Xiao Fu,Albert J. Jin,Xiao Tong,Gang Niu,Xiaoyuan Chen +12 more
TL;DR: A polymer nanovehicle for morphogen sustained release for directed differentiation of transplanted NSCs into desired neuronal subtypes and a bicistronic vector with a unique neuron specific gene tubb3 promoter to drive reporter gene expression for real-time imaging of NSC differentiation and migration are developed.
Journal ArticleDOI
Core-Shell-Heterostructured Magnetic-Plasmonic Nanoassemblies with Highly Retained Magnetic-Plasmonic Activities for Ultrasensitive Bioanalysis in Complex Matrix.
Liangwen Hao,Yuankui Leng,Lifeng Zeng,Xirui Chen,Jing Chen,Hong Duan,Xiaolin Huang,Yonghua Xiong,Xiaoyuan Chen +8 more
TL;DR: The core–shell‐heterostructured MPNAs can serve as a nanoanalytical platform for the separation and concentration of target compounds from complex biological samples using magnetic properties and simultaneous optical sensing using plasmonic properties.
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An Albumin-Binding T1- T2 Dual-Modal MRI Contrast Agents for Improved Sensitivity and Accuracy in Tumor Imaging.
Zijian Zhou,Ruiliang Bai,Zhantong Wang,Henry Bryant,Lixin Lang,Hellmut Merkle,Jeeva Munasinghe,Longguang Tang,Wei Tang,Rui Tian,Guocan Yu,Ying Ma,Gang Niu,Jinhao Gao,Xiaoyuan Chen +14 more
TL;DR: A novel albumin-binding molecule chelated with paramagnetic manganese ion was developed as a novel T1- T2 dual-modal MRI contrast agent at high magnetic field and led to greatly enhanced signal-to-noise ratios (SNR) and contrast- to-no noise ratios (CNR) in both subcutaneous and orthotopic brain tumor models compared with traditional MRI methods.
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Bioinspired Nanocomplex for Spatiotemporal Imaging of Sequential mRNA Expression in Differentiating Neural Stem Cells
Zhe Wang,Ruili Zhang,Ruili Zhang,Zhongliang Wang,Zhongliang Wang,He-Fang Wang,Yu Wang,Jun Zhao,Fu Wang,Fu Wang,Weitao Li,Gang Niu,Dale O. Kiesewetter,Xiaoyuan Chen +13 more
TL;DR: A multifunctional nanocomplex to enable self-activating and spatiotemporal imaging of the dynamics of mRNA sequential expression during the neural stem cell differentiation process showed improved enzymatic stability, fast recognition kinetics, and high specificity.
Journal ArticleDOI
EGFR-targeted therapy results in dramatic early lung tumor regression accompanied by imaging response and immune infiltration in EGFR mutant transgenic mouse models
Abhilash Venugopalan,Min-Jung Lee,Gang Niu,José Medina-Echeverz,Yusuke Tomita,Martin J. Lizak,Constance M. Cultraro,Robert Mark Simpson,Xiaoyuan Chen,Jane B. Trepel,Udayan Guha +10 more
TL;DR: Results of this study provide novel insight into the immediate-early therapeutic response to EGFR TKIs in vivo and correlated with the inhibition of downstream EGFR signaling, increased apoptosis, and decreased proliferation in the tumor tissues.