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Xiaoyuan Chen
Researcher at National University of Singapore
Publications - 1270
Citations - 115993
Xiaoyuan Chen is an academic researcher from National University of Singapore. The author has contributed to research in topics: Photothermal therapy & Medicine. The author has an hindex of 149, co-authored 994 publications receiving 89870 citations. Previous affiliations of Xiaoyuan Chen include Brown University & University of Southern California.
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Journal ArticleDOI
Ultrasmall copper-based nanoparticles for reactive oxygen species scavenging and alleviation of inflammation related diseases
Liu Tengfei,Bowen Xiao,Fei Xiang,Jiang-lin Tan,Zhuo Chen,Xiaorong Zhang,Chengzhou Wu,Zhengwei Mao,Zhengwei Mao,Gaoxing Luo,Xiaoyuan Chen,Jun Deng +11 more
TL;DR: The synthesis of ultrasmall copper-based nanozymes as reactive oxygen species scavengers are reported on and improved treatment outcomes in acute liver and kidney injury and wound healing in vivo are demonstrated.
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Intraoperative Imaging-Guided Cancer Surgery: From Current Fluorescence Molecular Imaging Methods to Future Multi-Modality Imaging Technology
TL;DR: The current intraoperative optical molecular imaging technologies, focusing on contrast agents and surgical navigation systems, and the future prospects of multi-modality imaging technology for intraoperative imaging-guided cancer surgery are reviewed.
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Activatable Singlet Oxygen Generation from Lipid Hydroperoxide Nanoparticles for Cancer Therapy
Zijian Zhou,Zijian Zhou,Jibin Song,Rui Tian,Rui Tian,Zhen Yang,Guocan Yu,Lisen Lin,Guofeng Zhang,Wenpei Fan,Fuwu Zhang,Gang Niu,Liming Nie,Xiaoyuan Chen +13 more
TL;DR: This study demonstrates the effectiveness of modulating biochemical reactions as a ROS source to exert cancer death through tumor-specific 1 O2 generation and subsequent ROS mediated mechanism.
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US imaging of tumor angiogenesis with microbubbles targeted to vascular endothelial growth factor receptor type 2 in mice.
Juergen K. Willmann,Ramasamy Paulmurugan,Kai Chen,Olivier Gheysens,Martin Rodriguez-Porcel,Amelie M. Lutz,Ian Y. Chen,Xiaoyuan Chen,Sanjiv S. Gambhir +8 more
TL;DR: In this paper, a contrast agent consisting of encapsulated gaseous microbubbles was developed specifically to bind to vascular endothelial growth factor receptor type 2 (VEGFR2) for imaging tumor angiogenesis in two murine tumor models.
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Simple bioconjugate chemistry serves great clinical advances: albumin as a versatile platform for diagnosis and precision therapy
Zhibo Liu,Xiaoyuan Chen +1 more
TL;DR: This review article summarizes the mainstream chemical strategies of developing HSA binding molecules for coupling with drug molecules, and concisely condense the recent progress of the most important clinical applications of HSA-binding platforms.