Xiaoyuan Chen

TL;DR: The preclinical data from the use of this model suggest that 177Lu-EB-RGD may be an effective treatment option for NSCLC and should be further evaluated in human trials.

TL;DR: The therapeutic effect of the modified 177Lu Evans Blue compound was superior to the that of the 177Lu-DOTA-TATE construct at the doses evaluated, and this design has been further improved by incorporating a modification to control the in vivo pharmacokinetics.

TL;DR: Smart gold nanoparticle-stabilized microbubbles composed of a gas-filled core and shell including smart gold nanoparticles which can be aggregated in tumors were applied as ultrasound-mediated cancer theranostics to enable photoacoustic monitoring and photothermal treatment of tumors.

TL;DR: In this paper, the authors review the different therapeutic strategies that have been developed based on nanotechnology to modulate macrophage functions, such as inhibition of macocyte recruitment to tumor, depletion of M2-polarized macrophages, reprograming of M 2 -polarization to M 1 −polarisation, and blocking of the CD47-signal-regulatory protein alpha (CD47-SIRPα) pathway.

TL;DR: A pair of enantiomeric alkynyl-protected L/D-Au10(C13H17O5)10 nanoclusters with strong chirality are prepared and applied as radiosensitizers and exhibit better radiosensitization effect in vitro, which is confirmed by research on mechanisms including reactive oxygen species (ROS) burst mediated DNA breakage, cell cycle arrest and up-regulation of apoptotic protein expression.