Xiaoyuan Chen

Bio: Xiaoyuan Chen is an academic researcher from National University of Singapore. The author has contributed to research in topics: Physics & Photothermal therapy. The author has an hindex of 149, co-authored 994 publications receiving 89870 citations. Previous affiliations of Xiaoyuan Chen include Brown University & University of Southern California.

A Novel Wireless Resource Management for the 6G-Enabled High-Density Internet of Things

Abstract: The huge number of Internet of Things (IoT) devices and sudden data packets make the process of wireless resource management in 6G networks very difficult. The design of a 6G network often needs to rely on the co-simulation of multiple technologies to complete. To solve this issue, this article proposes a novel wireless resource management technique specifically for 6G-network-enabled high-density IoT services, and builds a complete simulation platform architecture based on this target. Combining multiple wireless resource management technologies, the platform realizes the generation of multiple IoT services and multiple 6G scenarios to enhance the integrity of the design. The experimental results show that the speed of the platform based on this solution is significantly faster than that of the traditional platform, and it is especially suitable for wireless resource management in the 6G-enabled high-density IoT.

Facile synthesis of ternary CdMnS QD-based hollow nanospheres as fluorescent/magnetic probes for bioimaging

Abstract: In this study, fluorescent/magnetic dual-functional hollow nanospheres conducted by ternary CdMnS nanoparticles were synthesized via a facile Ostwald-ripening process. The as-prepared hollow nanospheres exhibited bright and tunable emission under excitation with a 365 nm UV light coupled with a strong MR signal, suggesting their promising applications in bioimaging.

Transferrin-conjugated paclitaxel prodrugs for targeted cancer therapy

Abstract: Paclitaxel (PTX) is one of the most effective chemotherapeutic drugs ever developed and is effective against a wide spectrum of tumors. The clinical application of PTX, however, is limited by its severe side effects. We developed new ligand-mediated prodrugs, namely, PTX conjugated with Fmoc-L-glutamic acid 5-tert-butyl ester (linker) and transferrin (Tf, ligand/carriers), to specifically target tumor cells/tissues. PTX was labeled with FITC or a near-infrared (NIR) dye ICG-Der-02, respectively, for in vitro and in vivo imaging studies. MTT assay and apoptosis studies demonstrated that the prodrug had efficient inhibition of tumor cell proliferation with low toxicity to normal cells. More importantly, the prodrug Tf–Glu–PTX displayed a potential to overcome PTX resistance in drug-resistant MDA-MB-231 cell lines. Our in vivo studies also demonstrated that Tf–Glu–PTX significantly decreased side effects and enhanced the antitumor efficiency compared to free PTX. Collectively, our study showed that Tf–Glu–PTX is a promising prodrug for targeted cancer therapy.

Photoacoustic Molecular Imaging using Single Walled Carbon Nanotubes in Living Mice

Abstract: Photoacoustic molecular imaging is an emerging technology offering non-invasive high resolution imaging of the molecular expressions of a disease using a photoacoustic imaging agent. Here we demonstrate for the first time the utility of single walled carbon nanotubes (SWNTs) as targeted imaging agents in living mice bearing tumor xenografts. SWNTs were conjugated with polyethylene-glycol-5000 connected to Arg-Gly-Asp (RGD) peptide to target the αvβ3 integrin that is associated with tumor angiogenesis. In-vitro, we characterized the photoacoustic spectra of the particles, their signal linearity and tested their uptake by αvβ3-expressing cells (U87MG). The photoacoustic signal of SWNTs was found not to be affected by the RGD conjugation to the SWNTs and was also found to be highly linear with concentration (R2 = 0.9997 for 25-400nM). The cell uptake studies showed that RGD-targeted SWNTs gave 75% higher photoacoustic signal than non-targeted SWNTs when incubated with U87MG cells. In-vivo, we measured the minimal detectable concentration of SWNTs in living mice by subcutaneously injecting SWNTs at increasing concentrations. The lowest detectable concentration of SWNTs in living mice was found to be 50nM. Finally, we administered RGDtargeted and non-targeted SWNTs via the tail-vein to U87MG tumor-bearing mice (n=4 for each group) and measured the signal from the tumor before and up to 4 hours post-injection. At 4 hours post-injection, tumors of mice injected with RGD-targeted SWNTs showed 8 times higher photoacoustic signal compared with mice injected with non-targeted SWNTs. These results were verified ex-vivo using a Raman microscope that is sensitive to the SWNTs Raman signal.

Pet imaging of vascular endothelial growth factor receptor (VEGFR), compositions for VEGF cancer imaging, and methods of VEGF cancer imaging

Abstract: Briefly described, embodiments of this disclosure include polypeptides, in particular a labeled VEGF protein, kits for imaging, methods for imaging tissue, methods of diagnosing the presence in a tissue of one or more of precancerous cells, cancerous cells, tumor cells, and cells related to ischemic or hypoxic related diseases, methods of monitoring the progress in a tissue of the presence of one or more of precancerous cells, cancerous cells, tumor cells, and cells related to ischemic or hypoxic related diseases, and the like

I and i

Abstract: There is, I think, something ethereal about i —the square root of minus one. I remember first hearing about it at school. It seemed an odd beast at that time—an intruder hovering on the edge of reality. Usually familiarity dulls this sense of the bizarre, but in the case of i it was the reverse: over the years the sense of its surreal nature intensified. It seemed that it was impossible to write mathematics that described the real world in …

疟原虫var基因转换速率变化导致抗原变异[英]／Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A

Abstract: 抗原变异可使得多种致病微生物易于逃避宿主免疫应答。表达在感染红细胞表面的恶性疟原虫红细胞表面蛋白1（PfPMP1）与感染红细胞、内皮细胞、树突状细胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作用。每个单倍体基因组var基因家族编码约60种成员，通过启动转录不同的var基因变异体为抗原变异提供了分子基础。

Chemistry and properties of nanocrystals of different shapes.

Abstract: The interest in nanoscale materials stems from the fact that new properties are acquired at this length scale and, equally important, that these properties * To whom correspondence should be addressed. Phone, 404-8940292; fax, 404-894-0294; e-mail, mostafa.el-sayed@ chemistry.gatech.edu. † Case Western Reserve UniversitysMillis 2258. ‡ Phone, 216-368-5918; fax, 216-368-3006; e-mail, burda@case.edu. § Georgia Institute of Technology. 1025 Chem. Rev. 2005, 105, 1025−1102