Xiaoyuan Chen

Bio: Xiaoyuan Chen is an academic researcher from National University of Singapore. The author has contributed to research in topics: Physics & Photothermal therapy. The author has an hindex of 149, co-authored 994 publications receiving 89870 citations. Previous affiliations of Xiaoyuan Chen include Brown University & University of Southern California.

Observation of the $Y(4230)$ and a new structure in $e^+e^- \rightarrow K^+K^-J/\psi$

Abstract: The cross sections of $e^+e^- \rightarrow K^+K^-J/\psi$ at center-of-mass energies from 4.127 to 4.600~GeV are measured based on 15.6 fb$^{-1}$ data collected with the BESIII detector operating at the BEPCII storage ring. Two resonant structures are observed in the line shape of the cross sections. The mass and width of the first structure are measured to be ($4225.3\pm2.3\pm21.5$) MeV and ($72.9\pm6.1\pm30.8$)~MeV, respectively. They are consistent with those of the established $Y(4230)$. The second structure is observed for the first time with a statistical significance greater than 8$\sigma$, denoted as $Y(4500)$. Its mass and width are determined to be ($4484.7\pm13.3\pm24.1$) MeV and ($111.1\pm30.1\pm15.2$) MeV, respectively. The first presented uncertainties are statistical and the second ones are systematic. The product of the electronic partial width with the decay branching fraction $ \Gamma(Y(4230)\to e^+ e^-) \mathcal{B}(Y(4230) \to K^+ K^- J/\psi)$ is reported.Content from this work may be used under the terms of the Creative Commons Attribution 3.0 licence. Any further distribution of this work must maintain attribution to the author(s) and the title of the work, journal citation and DOI. Article funded by SCOAP3 and published under licence by Chinese Physical Society and the Institute of High Energy Physics of the Chinese Academy of Science and the Institute of Modern Physics of the Chinese Academy of Sciences and IOP Publishing Ltd.

Flower-like Au-Fe 3 O 4 optical nanosensor for imaging protease expressions in vivo

Abstract: History has witnessed an enormous progress of developing nanocrystals into “smart” probes for either imaging or therapeutic applications. Such progress is in large part powered by our ability to manipulate the surface of nanoparticles, marked by the establishment of surface engineering techniques that permit facile docking of functional motifs onto particles. However, these techniques have been increasingly challenged by the growing needs of imparting multiple motifs onto a single nanoplatform without disturbing the balance among the particles' physiological stability, target specificity and biological activity. Biphasic composite nanoparticles yield a multiplied combination of structural and functional parameters thereby providing greater flexibility in the design of nanogadgets. Here we have used a flower-shaped Au-Fe 3 O 4 nanoparticle as a template to construct an optical probe that can be specifically activated by matrix metalloproteinases (MMPs) expressed in tumors. Gold nanoparticles have excellent quenching properties but labile surface chemistry in an in vivo environment; on the other hand, iron oxide nanoparticles afford robust surface chemistry but are suboptimal as energy receptors. By the marriage of the two, we have been able to combine the strengths of each component to yield a unified structure with a desired performance that would not be achievable with the separate components. Our results demonstrate that the architecture of nanoparticles can be modulated to tailor their function as molecular imaging/therapeutic agents.

Physics in the τ-charm Region at BESIII

Abstract: The Beijing Spectrometer (BESIII) collaboration uses ee collisions in the τ -charm energy region to study a broad spectrum of topics. These include studies of light mesons and light baryons, studies of charmonium, including exotic mesons and baryons containing charmonium, studies of charmed mesons and baryons, studies of QCD and τ physics, as well as searches for new physics. The following is a Snowmass white paper that outlines the BESIII accomplishments and potential in each of these areas.

Moving theranostics trom bench to bedside in an interdisciplinary research team.

Abstract: The Laboratory of Molecular Imaging and Nanomedicine of the National Institute of Biomedical Imaging and Bioengineering at the National Institutes of Health has been led by Xiaoyuan Chen since 2009. The Laboratory of Molecular Imaging and Nanomedicine contains three interdisciplinary, versatile groups: the Theranostic Nanomedicine; PET/Optical Imaging Probe; and Biological Molecular Imaging Sections, consisting of chemists, engineers, biologists and clinicians working together to transfer biomedical technology from bench to bedside. To find out more about our laboratory and meet our group, please visit us at www.nibib.nih.gov/Research/Intramural/xchen.

I and i

Abstract: There is, I think, something ethereal about i —the square root of minus one. I remember first hearing about it at school. It seemed an odd beast at that time—an intruder hovering on the edge of reality. Usually familiarity dulls this sense of the bizarre, but in the case of i it was the reverse: over the years the sense of its surreal nature intensified. It seemed that it was impossible to write mathematics that described the real world in …

疟原虫var基因转换速率变化导致抗原变异[英]／Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A

Abstract: 抗原变异可使得多种致病微生物易于逃避宿主免疫应答。表达在感染红细胞表面的恶性疟原虫红细胞表面蛋白1（PfPMP1）与感染红细胞、内皮细胞、树突状细胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作用。每个单倍体基因组var基因家族编码约60种成员，通过启动转录不同的var基因变异体为抗原变异提供了分子基础。

Chemistry and properties of nanocrystals of different shapes.

Abstract: The interest in nanoscale materials stems from the fact that new properties are acquired at this length scale and, equally important, that these properties * To whom correspondence should be addressed. Phone, 404-8940292; fax, 404-894-0294; e-mail, mostafa.el-sayed@ chemistry.gatech.edu. † Case Western Reserve UniversitysMillis 2258. ‡ Phone, 216-368-5918; fax, 216-368-3006; e-mail, burda@case.edu. § Georgia Institute of Technology. 1025 Chem. Rev. 2005, 105, 1025−1102