Xiaoyuan Chen

Bio: Xiaoyuan Chen is an academic researcher from National University of Singapore. The author has contributed to research in topics: Physics & Photothermal therapy. The author has an hindex of 149, co-authored 994 publications receiving 89870 citations. Previous affiliations of Xiaoyuan Chen include Brown University & University of Southern California.

Nanotheranostics-Based Imaging for Cancer Treatment Monitoring

Abstract: The rapidly developing field of cancer treatment requires versatile strategies for controlled drug delivery and diagnostics. Molecular imaging technology has gained attraction in cancer diagnosis and therapy, partially driven by nanoparticle-based theranostic agents. Nanotheranostics-based imaging platforms offer insights into both malignancy diagnosis and therapeutic response monitoring. Monitoring body response to certain cancer treatment will offer suitable pathological and surgical evaluation guides to evaluate how tumors shrink/metastasize, as well as the side effects associated with the therapeutic approach. This chapter summarizes fundamental imaging features of nanotheranostics, specifically, treatment monitoring in cancer therapy, with applications in therapeutic monitoring, such as tracking angiogenesis, metastasis, and apoptosis, following primary treatment. This chapter also offers an outlook for future translation and clinical applications of such multifunctional nanoconstructs.

Effect of chlorination on estrogenicity in chlorinated treated effluent

Abstract: Effluents from sewage treatment plants can be discharged into rivers with estrogenic contaminants at levels sufficient to induce adverse reproductive and fertility developments in humans and wildlife. Of great concern in recent years are the estrogenic activities of chlorinated by-products (CBPs) in effluents. Simplified cell proliferation tests using the human estrogen receptor-positive MCF-7 ATCC breast cancer cells (E-SCREEN) were performed to investigate the influence of chlorination on the estrogenicity in effluents. It was found that the increase of chlorine dosages from 0 mg/L to 4 mg/L led to the decrease of total content of estrogenic activity: the 17β-estradiol equivalent concentration (EEQ) from 22.40 to 8.35 ng/L. However, the increase of contact time from 10-30 minutes increased EEQ from 14.04 to 29.97 ng/L. Furthermore, increasing TOC level using humic acid from 5 mg/L to 15 mg/L in effluents correspondingly resulted in an increase of EEQ from 19.69-27.20 ng/L; it was thus confirmed that chlorination of humic acid could produce estrogenic by-products.

Imaging agents for imaging protease activity and uses thereof

Abstract: Disclosed are imaging agents having the following Formula I: (I); wherein F is a near infrared fluorophore, S is an enzymatically cleavable oligopeptide, Q is a fluorescence quencher molecule, and M is a moiety selected from the group consisting of PEG or derivative thereof and a targeting ligand, and wherein F, Q and M are linked to separate amino acids of the enzymatically cleavable oligopeptide. Compositions comprising such compounds, as well as methods of use, methods of identifying a cell or a population of cells in vivo expressing a protease of interest, and methods of treating a disease through imaging are also disclosed.

I and i

Abstract: There is, I think, something ethereal about i —the square root of minus one. I remember first hearing about it at school. It seemed an odd beast at that time—an intruder hovering on the edge of reality. Usually familiarity dulls this sense of the bizarre, but in the case of i it was the reverse: over the years the sense of its surreal nature intensified. It seemed that it was impossible to write mathematics that described the real world in …

疟原虫var基因转换速率变化导致抗原变异[英]／Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A

Abstract: 抗原变异可使得多种致病微生物易于逃避宿主免疫应答。表达在感染红细胞表面的恶性疟原虫红细胞表面蛋白1（PfPMP1）与感染红细胞、内皮细胞、树突状细胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作用。每个单倍体基因组var基因家族编码约60种成员，通过启动转录不同的var基因变异体为抗原变异提供了分子基础。

Chemistry and properties of nanocrystals of different shapes.

Abstract: The interest in nanoscale materials stems from the fact that new properties are acquired at this length scale and, equally important, that these properties * To whom correspondence should be addressed. Phone, 404-8940292; fax, 404-894-0294; e-mail, mostafa.el-sayed@ chemistry.gatech.edu. † Case Western Reserve UniversitysMillis 2258. ‡ Phone, 216-368-5918; fax, 216-368-3006; e-mail, burda@case.edu. § Georgia Institute of Technology. 1025 Chem. Rev. 2005, 105, 1025−1102