X
Xiaoyuan Chen
Researcher at National University of Singapore
Publications - 1270
Citations - 115993
Xiaoyuan Chen is an academic researcher from National University of Singapore. The author has contributed to research in topics: Photothermal therapy & Medicine. The author has an hindex of 149, co-authored 994 publications receiving 89870 citations. Previous affiliations of Xiaoyuan Chen include Brown University & University of Southern California.
Papers
More filters
Journal ArticleDOI
Chimeric ferritin nanocages for multiple function loading and multimodal imaging.
Xin Lin,Jin Xie,Gang Niu,Fan Zhang,Haokao Gao,Min Yang,Qimeng Quan,Maria A. Aronova,Guofeng Zhang,Seulki Lee,Richard D. Leapman,Xiaoyuan Chen +11 more
TL;DR: A good tumor targeting profile was observed, which was attributable to both the enhanced permeability and retention (EPR) effect and biovector mediated targeting, which promises ferritin particles as a powerful nanoplatfom in the era of nanomedicine.
Journal ArticleDOI
Protease-Activated Drug Development
TL;DR: This extensive review elucidate the importance of proteases and their role in drug development in various diseases with an emphasis on cancer and provides significant design considerations needed for the development of the next generation protease-targeted and prote enzyme-activatable prodrugs.
Journal ArticleDOI
Stimuli‐Responsive NO Release for On‐Demand Gas‐Sensitized Synergistic Cancer Therapy
TL;DR: The chemical design of various endogenous/exogenous stimuli-responsive NO-releasing nanomedicines and their biomedical applications for on-demand NO-sensitized synergistic cancer therapy are discussed and the potential challenges regarding NO gas therapy are described.
Journal ArticleDOI
Albumin/vaccine nanocomplexes that assemble in vivo for combination cancer immunotherapy.
Guizhi Zhu,Geoffrey M. Lynn,Orit Jacobson,Kai Chen,Yi Liu,Yi Liu,Huimin Zhang,Ying Ma,Fuwu Zhang,Rui Tian,Qianqian Ni,Siyuan Cheng,Zhantong Wang,Zhantong Wang,Nan Lu,Bryant C. Yung,Zhe Wang,Lixin Lang,Xiao Fu,Albert J. Jin,Ido D. Weiss,Harshad D. Vishwasrao,Gang Niu,Hari Shroff,Dennis M. Klinman,Robert A. Seder,Xiaoyuan Chen +26 more
TL;DR: The authors repurpose albumin-binding Evans blue to develop nanovaccines that co-deliver adjuvants and tumor neoantigens to antigen-presenting cells in lymph nodes, resulting in potent and durable antitumour immunity in combination immunotherapy.
Journal ArticleDOI
18F-labeled RGD peptide: initial evaluation for imaging brain tumor angiogenesis.
Xiaoyuan Chen,Ryan Park,Anthony H. Shahinian,Michel Tohme,Vazgen Khankaldyyan,Mohammed H. Bozorgzadeh,James R. Bading,Rex Moats,Walter E. Laug,Peter S. Conti +9 more
TL;DR: N-4-[(18)F]fluorobenzoyl labeled cyclic RGD peptide c(RGDyK) is a potential tracer for imaging alpha(v)beta(3)-integrin positive tumors in brain and other anatomic locations.