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Xiaoyuan Chen
Researcher at National University of Singapore
Publications - 1270
Citations - 115993
Xiaoyuan Chen is an academic researcher from National University of Singapore. The author has contributed to research in topics: Photothermal therapy & Medicine. The author has an hindex of 149, co-authored 994 publications receiving 89870 citations. Previous affiliations of Xiaoyuan Chen include Brown University & University of Southern California.
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Journal ArticleDOI
microPET-Based Biodistribution of Quantum Dots in Living Mice
Meike L. Schipper,Zhen Cheng,Sheen-Woo Lee,Laurent A. Bentolila,Gopal Iyer,Jianghong Rao,Xiaoyuan Chen,Anna M. Wu,Shimon Weiss,Sanjiv S. Gambhir +9 more
TL;DR: Rapid reticuloendothelial system clearance ofQD will require modification of QD for optimal utility in imaging living subjects, and formal quantitative biodistribution/imaging studies will be helpful in studying many types of nanoparticles, including quantum dots.
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Tumor-Specific Drug Release and Reactive Oxygen Species Generation for Cancer Chemo/Chemodynamic Combination Therapy.
Sheng Wang,Sheng Wang,Zhantong Wang,Guocan Yu,Zijian Zhou,Orit Jacobson,Yijing Liu,Ying Ma,Fuwu Zhang,Zhi-Yi Chen,Xiaoyuan Chen +10 more
TL;DR: The potent antitumor effect of the LaCIONPs is demonstrated by both in vitro and in vivo results, and is a promising nanomedicine for tumor‐specific chemo/chemodynamic combination therapy.
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Trafficking Mesenchymal Stem Cell Engraftment and Differentiation in Tumor-Bearing Mice by Bioluminescence Imaging†‡
Hui Wang,Feng Cao,Abhijit De,Yu-An Cao,Christopher H. Contag,Sanjiv S. Gambhir,Joseph C. Wu,Xiaoyuan Chen +7 more
TL;DR: The MSCs‐R can selectively localize, survive, and proliferate in both subcutaneous tumor and lung metastasis as evidenced by noninvasive bioluminescence imaging and ex vivo validation.
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Integrin Targeted Delivery of Chemotherapeutics
Kai Chen,Xiaoyuan Chen +1 more
TL;DR: Integrin αvβ3 is highly expressed on activated endothelial cells, new-born vessels as well as some tumor cells, but is not present in resting endothelial Cells and most normal organ systems, making it a suitable target for anti-tumor therapy.
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Supramolecular Polymer-Based Nanomedicine: High Therapeutic Performance and Negligible Long-Term Immunotoxicity.
Guocan Yu,Xinlian Zhao,Jiong Zhou,Zhengwei Mao,Xiaolin Huang,Zhantong Wang,Bin Hua,Yijing Liu,Fuwu Zhang,Zhimei He,Orit Jacobson,Changyou Gao,Weilin Wang,Chunyang Yu,Xinyuan Zhu,Feihe Huang,Xiaoyuan Chen +16 more
TL;DR: The sophisticated nanomedicine constructed from the obtained supramolecular polymer can be specifically delivered to tumor sites and rapidly excreted from body after drug release, thus effectively avoiding systemic toxicity, especially long-term immunotoxicity.