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Xiaoyuan Chen
Researcher at National University of Singapore
Publications - 1270
Citations - 115993
Xiaoyuan Chen is an academic researcher from National University of Singapore. The author has contributed to research in topics: Photothermal therapy & Medicine. The author has an hindex of 149, co-authored 994 publications receiving 89870 citations. Previous affiliations of Xiaoyuan Chen include Brown University & University of Southern California.
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Journal ArticleDOI
Endoplasmic Reticulum Targeting to Amplify Immunogenic Cell Death for Cancer Immunotherapy.
Hongzhang Deng,Hongzhang Deng,Zijian Zhou,Weijing Yang,Lisen Lin,Sheng Wang,Gang Niu,Jibin Song,Xiaoyuan Chen +8 more
TL;DR: This study presents a novel ICD amplifying, ER-targeting PDT strategy that can effectively eradicate primary tumors under NIR exposure, as well as distant tumors through an abscopal effect.
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Chemotherapeutic drug-photothermal agent co-self-assembling nanoparticles for near-infrared fluorescence and photoacoustic dual-modal imaging-guided chemo-photothermal synergistic therapy.
Yang Li,Guihua Liu,Jinyuan Ma,Jinyan Lin,Huirong Lin,Guanghao Su,Dengyue Chen,Shefang Ye,Xiaoyuan Chen,Xuan Zhu,Zhenqing Hou +10 more
TL;DR: A novel carrier‐free theranostic system with nanoscale characteristics for near‐infrared fluorescence (NIRF) and photoacoustic (PA) dual‐modal imaging‐guided synergistic chemo‐photothermal therapy (PTT) and co‐self‐assembly of both FDA‐approved agents provides a safe and “Molecular economical” strategy in the rational design of multifunctional nano‐theranostic systems.
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Tumor Vasculature Targeted Photodynamic Therapy for Enhanced Delivery of Nanoparticles
Zipeng Zhen,Wei Tang,Yen-Jun Chuang,Trever Todd,Weizhong Zhang,Xin Lin,Gang Niu,Gang Liu,Lianchun Wang,Zhengwei Pan,Xiaoyuan Chen,Jin Xie +11 more
TL;DR: A photodynamic therapy (PDT)-based EPR enhancement technology that uses RGD-modified ferritin (RFRT) as “smart” carriers that site-specifically deliver 1O2 to the tumor endothelium is introduced and has proven to be safe, selective, and effective.
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Triphase Interface Synthesis of Plasmonic Gold Bellflowers as Near-Infrared Light Mediated Acoustic and Thermal Theranostics
Peng Huang,Pengfei Rong,Pengfei Rong,Jing Lin,Wanwan Li,Xuefeng Yan,Molly Gu Zhang,Liming Nie,Liming Nie,Gang Niu,Jie Lu,Wei Wang,Xiaoyuan Chen +12 more
TL;DR: Upon near-infrared (NIR) laser irradiation, the gold bellflower GBFs, with strong NIR absorption, showed very strong PA response and an ultrahigh photothermal conversion efficiency (η, ∼74%) among the reported photothermal Conversion agents.
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Photosensitizer Loaded Nano-Graphene for Multimodality Imaging Guided Tumor Photodynamic Therapy
Pengfei Rong,Kai Yang,Avinash Srivastan,Dale O. Kiesewetter,Xuyi Yue,Fu Wang,Liming Nie,Ashwinkumar Bhirde,Zhe Wang,Zhuang Liu,Gang Niu,Wei Wang,Xiaoyuan Chen +12 more
TL;DR: A role for graphene as a carrier of PDT agents to improve PDT efficacy and increase long-term survival following treatment is identified and GO-PEG-HPPH offers dramatically improved cancer cell killing efficacy.